The Effect of Testosterone on Mood and Quality of Life

The Effect of Testosterone Treatment on Depressive Symptoms and Quality of Life in Older Men With Age-Related Hypogonadism and Subsyndromal Depression.

We hypothesize that testosterone replacement will improve mood and quality of life in older men with low testosterone and mild depression. Study subjects will receive either testosterone gel or a placebo (inactive) gel for 12 weeks. Neither the subject or the investigator will know whether they are receiving placebo or testosterone gel. At the end of the initial 12 week period, all subjects will receive testosterone gel for 12 more weeks. Mood and quality of life measures will be obtained at baseline, at the end of the double-blind phase and at the end of the extension phase (when all subjects receive testosterone.)

Study Overview

• Status: Completed
• Conditions: Depressive Disorder; Gonadal Disorders; Hypogonadism
• Intervention / Treatment: Drug: Testosterone gel

Detailed Description

This is a randomized, double-blind, placebo-controlled trial of testosterone replacement in older men with age-associated hypogonadism and subsyndromal depression. Men will receive either 7.5 gm/qd of testosterone gel or a placebo gel for 12 weeks. The double-blind phase will be followed by a 12 week open-label extension in which all subjects will receive 7.5 gm/qd of testosterone gel.

Procedures: Depressive symptoms will be assessed with the Hamilton Depression Rating Scale (HDRS) and the SCL-20, a 20-item self-report depression scale that has been shown to have high reliability and validity and to be sensitive to changes in depressive symptoms in outpatients in primary care settings. The short form (16 item) Endicott Quality of Life Enjoyment and Satisfaction Scale will be used to assess quality of life changes. The Medical Outcomes Study Short-Form 36 (SF-36) will be used to assess changes in functional status. Demographic information, medical history and current medications will be determined at baseline and follow up, via patient interview and chart review. Overall medical morbidity will be ascertained with the Cumulative Illness Rating Scale. All outcome measures (SCL-20, Endicott Quality of Life Scale, HDRS,SF-36) will be assessed at baseline, week 12 (end of the double-blind phase)and week 24 (end of the extension phase). Blood draws will be done at baseline, week 12 and week 24. Laboratory assays for testosterone leves at baseline, week 12 and week 24 will be performed at the same time to minimize interassay variability.

• Study Type: Interventional
• Enrollment (Actual): 33
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 50 years and older (ADULT, OLDER_ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Age: 50 or older
• Total Testosterone <=280 ng/dl
• Subsyndromal depressive disorder: either dysthymia or minor depression (per DSM IV and DSM IV appendix)

Exclusion Criteria:

• PSA >=3.0
• Klinefelter's syndrome
• Prostate or breast cancer
• Hospitalized in the past month
• Obstructive BPH
• Current testosterone treatment
• Schizophrenia, bipolar disorder, dementia
• Treatment with antipsychotics or benzodiazepines
• Alcohol dependence or other substance dependence
• Suicidal or psychotic symptoms

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: TRIPLE

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Hamilton Depression Rating Scale	12 and 24 weeks

Secondary Outcome Measures

Outcome Measure	Time Frame
SF-36	12 and 24 weeks
Endicott Short Quality of Life Scale	12 and 24 weeks
SCL-20	12 and 24 weeks

Collaborators and Investigators

• Sponsor: Seattle Institute for Biomedical and Clinical Research
• Collaborators: University of Washington; VA Puget Sound Health Care System; Solvay Pharmaceuticals; American Federation for Aging Research; Geriatric Research Education and Clinical Care
• Investigators: Principal Investigator: Molly M Shores, MD, University of Washington VA Puget Sound Health Care System, GRECC

Publications and helpful links

General Publications

• Shores MM, Kivlahan DR, Sadak TI, Li EJ, Matsumoto AM. A randomized, double-blind, placebo-controlled study of testosterone treatment in hypogonadal older men with subthreshold depression (dysthymia or minor depression). J Clin Psychiatry. 2009 Jul;70(7):1009-16. doi: 10.4088/jcp.08m04478.

Study record dates

Study Major Dates

• Study Start: November 1, 2002
• Primary Completion (ACTUAL): December 1, 2005
• Study Completion (ACTUAL): November 1, 2006

Study Registration Dates

• First Submitted: September 12, 2005
• First Submitted That Met QC Criteria: September 12, 2005
• First Posted (ESTIMATE): September 20, 2005

Study Record Updates

• Last Update Posted (ESTIMATE): October 1, 2008
• Last Update Submitted That Met QC Criteria: September 30, 2008
• Last Verified: September 1, 2008

More Information

Terms related to this study

• Keywords: quality of life; depression; testosterone; subsyndromal depression
• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Mood Disorders; Endocrine System Diseases; Depressive Disorder; Disease; Hypogonadism; Gonadal Disorders; Physiological Effects of Drugs; Hormones; Hormones, Hormone Substitutes, and Hormone Antagonists; Androgens; Testosterone
• Other Study ID Numbers: RDIS 0004; AFAR: A02034; Solvay:UMD-02-097