- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00244127
Open Label, Single Arm, Phase II Study Using R-COMP in Elderly Patients With Aggressive NHL.
October 26, 2005 updated by: Zeneus Pharma
Cyclophosphamide, Oncovin, Myocet, Prednisone and Rituximab (R-COMP) in the Treatment of Elderly Patients With Aggressive NHL.
To evaluate the safety and efficacy of R-COMP in elderly patients with advanced aggressive NHL.
Myocet (non-pegylated liposomal doxorubicin) replaces conventional doxorubicin in the R-CHOP regimen.
Study Overview
Status
Unknown
Intervention / Treatment
Detailed Description
To evaluate the duration of remission, disease free survival and 2-year survival of R-COMP in first line therapy of elderly patients with advanced aggressive NHL.
To evaluate the tolerability of R-COMP in first line therapy of elderly patients with advanced aggressive NHL.
Study Type
Interventional
Enrollment
75
Phase
- Phase 2
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Paris, France
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Berlin, Germany
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Modena, Italy, 41100
- Universita Degli Studi Di Modena AZ Ospedaliere Policlinico
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Barcelona, Spain
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Leicester, United Kingdom
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
65 years and older (Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Diffuse Large B-Cell Lymphoma (DLBCL), and their morphologic variants and subtypes, i.e. Centroblastic lymphoma, Immunoblastic lymphoma, T-cell rich/B-cell lymphoma, anaplastic large B-cell lymphoma, mediastinal (thymic) large B-cell lymphoma;
- Primary diffuse large B-cell lymphoma of MALT (incorrectly defined as high-grade MALT lymphoma);
- Marginal zone B-cell lymphoma with coexisting areas of DLBCL;
- Age of ≥60 years;
- Clinical stage at diagnosis: I A bulky - IV B;
- CD20 positivity;
- Serum negativity for HbsAg and HCV except for those with no sign of active viral replication, assessed by HCV-RNA copies;
- Absolute neutrophil count (ANC) ≥1.5x109/L, and platelet count ≥100x109/L (unless both are attributed directly to bone marrow involvement by lymphoma or auto-immune disease secondary to lymphoma);
- Serum creatinine ≤130μM/L, serum bilirubin ≤2.5xULN aspartate amino-transferase (AST/GOT), ≤2.5xULN alanine amino-transferase (ALT/GPT) ≤2.5xULN, and alkaline phosphatase ≤4 times the upper limit of normal (unless the increase is attributed directly to the presence of tumour by the Investigator)
- Left ventricular ejection fraction (LVEF) ≥50%;
- ECOG performance status 0-2;
- At least one measurable lesion is mandatory;
- Written informed consent given at time of registration;
- Males and females (both males and females of childbearing potential must agree to use adequate contraception for the duration, and for 3 months after the completion, of the treatment).
Exclusion Criteria:
- Clinical stage I non-bulky, or CS IIA with less than three sites of disease involved (patients with stage IIB are eligible, regardless of the number of sites involved);
- Tumour involvement of CNS;
- Indolent lymphoma transformed in more aggressive histological type, even if never previously treated;
- Mantle Cell Lymphoma, Peripheral T cell Lymphoma and their variants;
- Aggressive non-Hodgkin's lymphoma in transplanted patient;
- Clinically significant secondary cardiovascular disease, e.g. uncontrolled hypertension, (resting diastolic blood pressure >115 mmHg), uncontrolled multifocal cardiac arrhythmias, symptomatic angina pectoris or congestive cardiac failure NYHA class III-IV;
- Evidence of any severe active acute or chronic infection;
- Concurrent malignancy or history of other malignancy, except basal cell carcinoma of the skin (BCC) and in-situ cervical carcinoma (CIN) / Myelodysplastic syndrome;
- HbsAg, HIV-positive, or HCV-RNA-positive patients;
- Inability to comply with study procedures;
- Prior CNS lymphoma;
- Prior radiation to non-CNS lymphoma mass(es) as a treatment for lymphomas;
- History of allergic reaction to anthracyclines, eggs, and egg products or known sensitivities, or history of unusual reaction, to other components of, or treatments similar to, the investigational treatment regimen;
- Presence of other medication that may interfere with study treatment or the action of the investigational product or confuse the assessment of study results
- Pregnant women or nursing mothers;
- Participation in an investigational drug study within 4 weeks prior to study entry.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Response rate
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Massimo Federico, Università degli Studi di Modena
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
October 1, 2002
Study Registration Dates
First Submitted
October 24, 2005
First Submitted That Met QC Criteria
October 24, 2005
First Posted (Estimate)
October 25, 2005
Study Record Updates
Last Update Posted (Estimate)
October 28, 2005
Last Update Submitted That Met QC Criteria
October 26, 2005
Last Verified
October 1, 2005
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Behavioral Symptoms
- Aggression
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Anti-Inflammatory Agents
- Antirheumatic Agents
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Glucocorticoids
- Hormones
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Antineoplastic Agents, Hormonal
- Antineoplastic Agents, Alkylating
- Alkylating Agents
- Myeloablative Agonists
- Antineoplastic Agents, Phytogenic
- Antineoplastic Agents, Immunological
- Cyclophosphamide
- Rituximab
- Prednisone
- Vincristine
Other Study ID Numbers
- Myocet 018
- The MYOCAN Study
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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