- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00420225
Mesh Repair of Anterior Vaginal Wall Prolapse
Low-Weight Polypropylene Mesh for Anterior Vaginal Wall Prolapse: A Prospective Randomized Study
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Anterior vaginal wall prolapse is the most common type of pelvic organ prolapse in postmenopausal women. This anatomic defect has traditionally been repaired with anterior colporrhaphy plication, a series of interrupted stitches being the main surgical component. The procedure is associated with a high recurrence rate, up to 32 % even after using paravaginal repair along with anterior colporrhaphy.It has been sought to resolve the problem of recurrence using artificial mesh as in the repair of abdominal hernias.
Comparison: Anterior vaginal wall repair with or without reinforcement with polypropylene mesh were compared in a prospective randomized study
Study Type
Enrollment
Phase
- Phase 3
Contacts and Locations
Study Locations
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Tampere, Finland, 33521
- Tampere University Hospital, Department of Obstetrics and Gynaecology
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Postmenopausal women with symptomatic anterior vaginal wall prolapse to the hymen or beyond when under strain and referred for reconstructive pelvic surgery
Exclusion Criteria:
- an apical defect indicating concomitant vaginal fixation, or stress urinary incontinence necessitating surgery, or her main symptomatic prolapse component was in the posterior vaginal wall.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
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Recurrence of anterior vaginal wall prolapse
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Secondary Outcome Measures
Outcome Measure |
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Complications
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Postvoidal residual urine
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Symptom resolution
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Kari Nieminen, Tampere University Hospital, Department of Obstetrics and Gynecology
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Study Completion
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- Tampere University Hospital
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Anterior Vaginal Wall Prolapse
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University of SalfordUnknownPelvic Organ Prolapse | Cystocele | Uterine Prolapse | Rectocele | Anterior Wall; Prolapse, Vaginal | Posterior Wall; Prolapse, Vaginal | Vault Prolapse, VaginalUnited Kingdom
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Lyra Medical Ltd.CompletedAnterior Vaginal Wall Prolapse With/Without Apical/Uterine DescentIsrael
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Lyra Medical Ltd.CompletedAnterior Vaginal Wall Prolapse | Vaginal Apex/Uterine ProlapseHungary, Israel
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University of LouisvilleKARL STORZ Endoscopy-America, Inc.CompletedFistula | Pelvic Organ Prolapse | Incontinence | Prolapse of Vaginal Vault After Hysterectomy | Bulging of Vaginal WallUnited States
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Azienda Ospedaliera Cardinale G. PanicoCompletedPelvic Organ Prolapse | Posterior Vaginal Wall ProlapseItaly
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University of California, IrvineTerminatedPelvic Organ Prolapse | Posterior Vaginal Wall DefectsUnited States
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Kaiser PermanenteCompletedPelvic Organ Prolapse | Anterior Vaginal Wall Prolapse | CystoceleUnited States
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EgymedicalpediaCompletedVaginal Wall ProlapseEgypt
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