- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00476489
Does Topical Steroid Treatment Impair the Adrenal Function?
Low Dose (1mcg) ACTH Stimulation Test for Assessment of the Hypothalamo-Pituitary- Adrenal Axis in Patients Treated With Topical Corticosteroids
Study Overview
Status
Detailed Description
Adrenocortical suppression is a potential complication of systemic corticosteroid treatement but also of non systemic therapy like topical therapy.
The normalcy of hypothalamic-pituitary-adrenal axis ( HPA axis) of patients with chronic skin diseases like atopic dermatitis, pemphigus or psoriasis which are treated with topical steroids, will be assessed with the low dose (1mcg) adrenocortocotropin ( ACTH) stimulation test. During this test serum cortisol levels are measured before, 30 and 60 mn after intravenous administration of 1mcg of ACTH (synacthen).The results will be compared with age and sex matched subjects with normal HPA axis as assessed by low dose ACTH stimulation test.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Avraham Ishay, MD
- Phone Number: 972-4-6495556
- Email: ishay_av@clalit.org.il
Study Contact Backup
- Name: Rafael Luboshitzky, MD
- Email: r_luboshitzky@clalit.org.il
Study Locations
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Afula, Israel, 18101
- Recruiting
- Haemek Medical Center
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Contact:
- Avraham Ishay, MD
- Phone Number: 972-4-6495556
- Email: ishay_av@clalit.org.il
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- patients receiving daily topical steroids for at least two weeks on 10% or more of body surface.
Exclusion Criteria:
- patients treated with any form of corticosteroids except topical steroids.
- patients with known pituitary disease
- pregnant patients
Study Plan
How is the study designed?
Design Details
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Avraham Ishay, MD, Haemek Medical Center
Study record dates
Study Major Dates
Study Start
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 02307EMC
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