- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00643266
Recollection Training in Healthy Older Adults and Older Adults With Amnestic Mild Cognitive Impairment
Memory Interventions for Older Adults
We have developed a training intervention that successfully improves older adults' memory. We have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old) use an altered pattern of memory-related brain activity compared to younger adults, whereas healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful, Recollection-based memory processes, whereas their automatic, Familiarity-based memory processes are intact. Our primary current goal is to investigate whether our successful memory intervention will improve Recollection and produce induce altered patterns of brain activity in the Lo-Old and aMCI.
Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive the memory intervention, while the other half in each group will receive a control program consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned while performing the two memory tasks. We predict that the memory intervention will improve performance on a number of memory tasks, and will induce altered patterns of brain activity. In the Lo-Old, their brain activity after the memory intervention will look more like the Hi-Old, while brain activity will become more focal in the aMCI.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Ontario
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Toronto, Ontario, Canada, M6A 2E1
- Baycrest
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-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- 65-90 years old
- English as a first language or learned before kindergarten
- Right handed
Exclusion Criteria:
- Neurologic disorder
- Major medical disorder affecting cognition
- Psychiatric disorder
- Metal in the body that poses a hazard in the MRI scanner
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 1
Recollection training via graduated increases in task difficulty, carried out over 36 sessions over 9 training days
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Participants are exposed to long lists of words.
Each word is presented either visually or auditorily, and each word is repeated after a variable number of intervening words (the lag), in each the same modality, or the other modality.
Participants are instructed to respond "yes" only to words repeated in the same modality.
If a performance criterion is met, the lag is increased for the next session; if the performance criterion is not met, the same lag is repeated in the next session.
Other Names:
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Active Comparator: 2
Computer-delivered information sessions about memory and aging with Jeopardy-like games to engage participants
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Participants view PowerPoint presentations on various topics related to memory and aging (e.g., structural brain changes, diet, stress, depression) and how each of these topics affect memory, and after each presentation, play a Jeopardy-like game to test their knowledge gain
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Recollection estimates
Time Frame: Immediately post-training and three months post-training
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Recollection, defined as Correct "yes" responses to "Same" repetitions minus Incorrect "yes" responses to "Different" repetitions, as a function of condition (trained versus control), lag (3, 16) and time (pre-, post-, and 3 month follow-up)
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Immediately post-training and three months post-training
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Brain activation as assessed by functional magnetic resonance imaging
Time Frame: Immediately post-training
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Prefrontal (inferior, middle, and superior frontal gyri) activation for Different Repetitions minus Same Repetitions, as a function of group (trained versus control), lag (3, 16), and time (pre, post).
Additional analyses will compare trained versus control older adults with younger adults on these measures at baseline (pre).
Analyses will include an exploration of prefrontal laterality of the effects (left minus right), to see whether training induces greater bilaterality of activation.
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Immediately post-training
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Transfer to other recollection-dependent task and to subjective memory measures
Time Frame: Immediately post-training and three months post-training
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Source memory, self-ordered pointing, n-back, a Sternberg task, CVLT, an AB-AC test of proactive interference, the Memory Controllability Inventory, Multifactorial Memory Questionnaire (Ability and Contentment subscales), Meta-Memory in Adulthood questionnaire (locus of control, anxiety, and capability subscales), and an in-house measure of the efficacy of the control program
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Immediately post-training and three months post-training
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Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Nicole D Anderson, PhD, CPsych, Baycrest
Publications and helpful links
General Publications
- Anderson ND, Ebert PL, Jennings JM, Grady CL, Cabeza R, Graham SJ. Recollection- and familiarity-based memory in healthy aging and amnestic mild cognitive impairment. Neuropsychology. 2008 Mar;22(2):177-87. doi: 10.1037/0894-4105.22.2.177.
- Guild EB, Vasquez BP, Maione AM, Mah L, Ween J, Anderson ND. Dynamic working memory performance in individuals with single-domain amnestic mild cognitive impairment. J Clin Exp Neuropsychol. 2014;36(7):751-60. doi: 10.1080/13803395.2014.941790. Epub 2014 Aug 30.
- Ebert PL, Anderson ND. Proactive and retroactive interference in young adults, healthy older adults, and older adults with amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan;15(1):83-93. doi: 10.1017/S1355617708090115.
- Anderson ND, Ebert PL, Grady CL, Jennings JM. Repetition lag training eliminates age-related recollection deficits (and gains are maintained after three months) but does not transfer: Implications for the fractionation of recollection. Psychol Aging. 2018 Feb;33(1):93-108. doi: 10.1037/pag0000214.
- Meusel LA, Grady CL, Ebert PE, Anderson ND. Brain-behavior relationships in source memory: Effects of age and memory ability. Cortex. 2017 Jun;91:221-233. doi: 10.1016/j.cortex.2016.12.023. Epub 2017 Jan 12.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- RecollectionTraining
- CIHR MOP 67015
- ASC 08 95
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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