- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00700310
Evaluating Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures
December 17, 2015 updated by: Eisai Inc.
A Double-Blind, Placebo-Controlled, Dose-Escalation, Parallel-Group Study to Evaluate the Efficacy and Safety of E2007 (Perampanel) Given as Adjunctive Therapy in Subjects With Refractory Partial Seizures
The purpose of this study is to evaluate the efficacy, safety and tolerability of perampanel when given as an adjunctive therapy in subjects with refractory partial seizures.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
712
Phase
- Phase 3
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
-
Clayton, Australia, 3168
-
Fitzroy, Australia, 3065
-
Parkville, Australia, 3050
-
West Heidelberg, Australia, 3081
-
Woodville, Australia, 5011
-
-
South Australia
-
Woodville, South Australia, Australia, 5011
- The Queen Elizabeth Hospital
-
Woodville South, South Australia, Australia, 5011
-
-
Victoria
-
Clayton, Victoria, Australia, 3168
-
Fitzroy, Victoria, Australia, 3065
-
Heidelberg, Victoria, Australia, 3081
-
Parkville, Victoria, Australia, 3050
-
-
-
-
-
Pleven, Bulgaria, 5800
-
Plovdiv, Bulgaria, 4002
-
Sofia, Bulgaria, 1606
-
Sofia, Bulgaria, 1113
-
-
-
-
-
Brno, Czech Republic, 625 00
-
Olomouc, Czech Republic, 775 20
-
Praha 4, Czech Republic, 140 59
-
Praha 5, Czech Republic, 150 06
-
-
-
-
-
Tallinn, Estonia, EE-10617
-
Tallinn, Estonia, EE-13419
-
Tartu, Estonia, EE-51014
-
-
-
-
-
Dusseldorf, Germany, 40212
-
Kehl-Kork, Germany, 77694
-
Konigstein-Falkenstein, Germany, D-61462
-
Mainz, Germany, 55101
-
Marburg, Germany, 35039
-
Munchen, Germany, 81377
-
Munchen, Germany, 80333
-
Ulm, Germany, 89075
-
Westerstede, Germany, 26655
-
-
-
-
-
Hong Kong, Hong Kong
-
Hong Kong, Hong Kong, 999077
- Queen Mary Hospital
-
Kowloon, Hong Kong
-
Kowloon, Hong Kong
- Queen Elizabeth Hospital
-
Kowloon, Hong Kong
- United Christian Hospital
-
Shatin, Hong Kong
- Prince of Wales Hospital
-
-
-
-
-
Budapest, Hungary, 1083
-
Budapest, Hungary, 1145
-
Budapest, Hungary, 1096
-
Budapest, Hungary, 1146
-
Kecskemet, Hungary, 6000
-
-
-
-
-
New Delhi, India, 110002
-
-
Andhra Pradesh
-
Hyderabad, Andhra Pradesh, India, 500001
-
Hyderabad, Andhra Pradesh, India, 500082
-
Vishakhapatnam, Andhra Pradesh, India, 530002
-
-
Maharashtra
-
Mumbai, Maharashtra, India, 400026
-
Pune, Maharashtra, India, 411030
-
Pune, Maharashtra, India, 411011
-
-
Rajasthan
-
Jaipur, Rajasthan, India, 302004
-
-
-
-
-
Milano, Italy, 20133
-
Napoli, Italy, 80128
-
Padova, Italy, 35128
-
Siena, Italy, 53100
-
Torino, Italy, 10126
-
-
-
-
-
Busan, Korea, Republic of, 602715
-
Busan, Korea, Republic of, 614735
-
Daegu, Korea, Republic of, 700712
-
Seoul, Korea, Republic of, 110744
-
Seoul, Korea, Republic of, 138736
-
Seoul, Korea, Republic of, 135710
-
Seoul, Korea, Republic of, 120752
-
-
-
-
-
Riga, Latvia, LV-1038
-
Riga, Latvia, LV-1004
-
Valmiera, Latvia, LV-4201
-
-
-
-
-
Kaunas, Lithuania, LT-50009
-
Klaipeda, Lithuania, LT-92288
-
Vilnius, Lithuania, LT-08661
-
-
-
-
Terengganu
-
Kuala Terengganu, Terengganu, Malaysia, 24000
-
-
Wilayah Persekutuan
-
Kuala Lumpur, Wilayah Persekutuan, Malaysia, 59100
-
-
-
-
-
Ermita, Philippines, 1000
-
Makati City, Philippines, 1229
-
-
-
-
-
Bialystok, Poland, 15-276
-
Gdansk, Poland, 80-803
-
Gdansk, Poland, 80-952
-
Katowice, Poland, 40-635
-
Katowice, Poland, 40-635
- Samodzielny Publiczny Szpital Kliniczny nr 7 Slaskiego Uniwersytetu Medycznego w Katowicach
-
Lodz, Poland, 93-513
-
Lublin, Poland, 20-718
-
Warszawa, Poland, 02-957
-
-
-
-
-
Coimbra, Portugal, 3000-075
-
Lisboa, Portugal, 1649-035
-
Porto, Portugal, 4200-319
-
Porto, Portugal, 4099-001
-
-
-
-
-
Brasov, Romania, 500061
-
Bucharest, Romania, 020125
- Colentina Clinical Hospital
-
Bucharest, Romania, 011635
- Sapiens Medical Center
-
Bucharest, Romania, 011635
-
Bucharest, Romania, 20125
-
Cluj Napoca, Romania, 400012
- Emergency County Clinical Hospital
-
Cluj Napoca, Romania, 400012
- Pediatric Neurology Clinic of Emergency Children Hospital
-
Cluj Napoca, Romania, 400012
-
-
-
-
-
Ekaterinburg, Russian Federation, 620149
-
Moscow, Russian Federation, 107076
-
Moscow, Russian Federation, 107066
-
Moscow, Russian Federation, 107066
- Moscow State University of Medicine and Dentistry
-
Moscow, Russian Federation, 107076
- Moscow Research Institute of Psychiatry
-
Moscow, Russian Federation, 125412
- Moscow Research Institute of Pediatrics and Pediatric Surgery
-
Moscow, Russian Federation, 125412
-
Samara, Russian Federation, 443095
-
Tyumen, Russian Federation, 625039
-
Yaroslavl, Russian Federation, 150030
-
-
-
-
-
Belgrade, Serbia, 11000
-
Nis, Serbia, 18000
-
Novi Sad, Serbia, 21000
-
-
-
-
-
Barcelona, Spain, 08003
-
Valencia, Spain, 46009
-
-
Andalucia
-
Granada, Andalucia, Spain, 18012
-
-
Cataluna
-
Badalona, Cataluna, Spain, 8916
-
Barcelona, Cataluna, Spain, 8003
-
Barcelona, Cataluna, Spain, 8025
-
-
Comunidad Valenciana
-
Valencia, Comunidad Valenciana, Spain, 46009
-
Valencia, Comunidad Valenciana, Spain, 46014
-
-
Comunidad de Madrid
-
Alcorcon, Comunidad de Madrid, Spain, 28922
-
Madrid, Comunidad de Madrid, Spain, 28040
-
-
-
-
-
Kaohsiung, Taiwan, 833
-
Taichung, Taiwan, 404
-
Taichung, Taiwan, 40705
-
Tainan, Taiwan, 704
-
Taoyuan, Taiwan, 333
-
-
-
-
-
Bangkok, Thailand, 10400
-
Bangkok, Thailand, 10700
-
Bangkok, Thailand, 10330
-
Chiang Mai, Thailand, 50200
-
Khon Kaen, Thailand, 40004
-
Muang District, Thailand, 34000
-
-
-
-
-
Dnipropetrovsk, Ukraine, 49027
-
Dnipropetrovsk, Ukraine, 40927
-
Donetsk, Ukraine, 83114
-
Donetsk, Ukraine, 83052
-
Kharkiv, Ukraine, 61068
-
Kharkiv, Ukraine, 61018
-
Kyiv, Ukraine, 04080
-
Kyiv, Ukraine, 04209
-
Kyiv, Ukraine, 040209
-
Lviv, Ukraine, 79010
-
Uzhgorod, Ukraine, 88018
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
12 years to 120 years (Child, Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Provide written informed consent signed by the subject or legal guardian prior to entering the study or undergoing any study procedures (If the written informed consent is provided by the legal guardian because the subject is unable to do so, a written or verbal assent from the subject must also be obtained.).
- Be considered reliable and willing to be available for the study period and able to record seizures and report AEs them self or have a caregiver who can record seizures and report AEs for them;
- Male or female and greater than or equal to 12 years of age (within the course of the study), or greater than or equal to 18 years of age (depending on location) at the time of signing the informed consent.
- Females should be either of non-childbearing potential (defined as having undergone surgical sterilization, or postmenopausal [age 50 and amenorrheic for 12 months]) or of childbearing potential. Females of childbearing potential must have a negative serum beta-human chorionic gonadotropin (ß-hCG) at Visit 1 and a negative urine pregnancy test prior to randomization at Visit 2. Female subjects of childbearing potential must agree to be abstinent or to use at least 1 medically acceptable methods of contraception (eg, a double-barrier method [eg, condom + spermicide, condom + diaphragm with spermicide], IUD, or have a vasectomised partner) starting at Visit 1 and throughout the entire study period and for 2 months after the last dose of study drug. Those women using hormonal contraceptives must also be using an additional approved method of contraception (as described previously) starting at Visit 1 and continuing throughout the entire study period and for 2 months after the last dose of study drug. (It is not required for male subjects to use contraceptive measures based on preclinical toxicology data.);
- Have a diagnosis of epilepsy with partial seizures with or without secondarily generalized seizures according to the International League Against Epilepsy's Classification of Epileptic Seizures (1981). Diagnosis should have been established by clinical history and an electroencephalogram (EEG) that is consistent with localization-related epilepsy; normal interictal EEGs will be allowed provided that the subject meets the other diagnosis criterion (ie, clinical history);
- Have had a computed tomography (CT) or magnetic resonance imaging (MRI) within the last 10 years that ruled out a progressive cause of epilepsy;
- Have uncontrolled partial seizures despite having been treated with at least 2 different anti-epileptic drugs (AEDs) within approximately the last 2 years;
- During the 6-week Pre-randomization Phase subjects must have had >/= 5 partial seizures per 6-week (with >/=2 partial seizures per each of 3-week period) and with no 25-day seizure-free period in the 6-week period, as documented via a valid seizure diary. Only simple partial seizures with motor signs, complex partial seizures, and complex partial seizures with secondary generalization are counted toward this inclusion;
- Are currently being treated with stable doses of 1, 2 or a maximum of 3 approved AEDs. Only 1 inducer AED (defined as; carbamazepine, phenytoin, phenobarbital, or primidone only) out of the maximum of 3 AEDs is allowed;
- Are on a stable dose of the same concomitant AED(s) for 1 month (or no less than 21 days) prior to Visit 1; in the case where a new AED regime has been initiated for a subject, the dose must be stable for 2 months (or no less than 49 days) prior to Visit 1;
- If on a stable dose (other than intermittent rescue use) of benzodiazepines for epilepsy (or for anxiety or sleep disorders) the prescribed dose must be stable for 1 month (or no less than 21 days) prior to Visit 1. (Note: the use of intermittent rescue benzodiazepines is defined in the exclusion criterion #22 below.) When used in these cases (epilepsy, anxiety or sleep disorders), benzodiazepines will be counted as 1 AED; therefore, only 1 or a maximum of 2 additional approved AEDs will be allowed;
- A vagal nerve stimulator (VNS) is allowed but it must have been implanted >/= 5 months prior to Visit 1. Stimulator parameters can not be changed for 1 month (or no less than 21 days) prior to Visit 1 or thereafter during the study.
Exclusion Criteria:
- Participated in a study involving administration of an investigational compound or device within 1 month (or no less than 21 days) prior to Visit 1, or within approximately 5 half-lives of the previous investigational compound, whichever is longer;
- Pregnant and/or lactating;
- Participated in previous perampanel studies;
- Presence of nonmotor simple partial seizures only;
- Presence of primary generalized epilepsies or seizures, such as absences and or myoclonic epilepsies;
- Presence or previous history of Lennox-Gastaut syndrome;
- A history of status epilepticus within approximately 12 months prior to Visit 1;
- Seizure clusters where individual seizures cannot be counted;
- A history of psychogenic seizures;
- Evidence of clinically significant disease (eg, cardiac, respiratory, gastrointestinal, renal disease) that in the opinion of the Investigator(s) could affect the subject's safety or the study conduct;
- Scheduled and/or confirmed to have epilepsy surgery within 6 months after Visit 1; however those who have previously documented "failed" epilepsy surgery will be allowed;
- Evidence of significant active hepatic disease. Stable elevations of liver enzymes, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) due to concomitant medication(s) will be allowed if they are less than 3 times the upper limit of normal (ULN);
- Evidence of significant active hematological disease; white blood cell (WBC) count <= 2500/µL (2.50 1E+09/L) or an absolute neutrophil count <= 1000/µL (1.00 1E+09/L);
- A clinically significant ECG abnormality, including prolonged QTc defined as >450 msec;
- Suffering from psychotic disorder(s) and/or unstable recurrent affective disorder(s) evident by use of antipsychotics or have had a suicide attempt(s) within the last 2 years.
- Presence of a progressive central nervous system (CNS) disease, including degenerative CNS diseases and progressive tumors;
- History of drug or alcohol dependency or abuse within approximately the last 2 years;
- Have had multiple drug allergies or a severe drug reaction to an AED(s), including dermatological (eg, Stevens-Johnson syndrome), hematological, or organ toxicity reactions;
- If felbamate is used as a concomitant AED, subjects must be on felbamate for at least 2 years, with a stable dose for 2 months (or no less than 49 days) prior to Visit 1. They must not have a history of white blood cell (WBC) count below 2500/µL (2.50 1E+09/L), platelets below 100,000, liver function tests (LFTs) above 3 times the upper limit of normal (ULN), or other indication of hepatic or bone marrow dysfunction while receiving felbamate. If patients received felbamate in the past, it must have been discontinued 2 months (or no less than 49 days) prior to Visit 1;
- Concomitant use of vigabatrin. Subjects who took vigabatrin in the past must be off vigabatrin for approximately 5 months prior to Visit 1 and must have documentation showing no evidence of a vigabatrin associated clinically significant abnormality in a visual perimetry test;
- Concomitant use of barbiturates (except for seizure control indication) within 1 month (or no less than 21 days) prior to Visit 1;
- Use of intermittent rescue benzodiazepines (ie, 1-2 doses over a 24-hr period considered one-time rescue) 2 or more times in a 1-month period prior to Visit 1; or
- Any condition(s) that will make the subject, in the opinion of the Investigator, unsuitable for the study.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: 2
|
2 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
4 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
8 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
|
Active Comparator: 1
|
2 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
4 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
8 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
|
Placebo Comparator: 4
|
Placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily.
|
Active Comparator: 3
|
2 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
4 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
8 mg perampanel or placebo in a 1:1:1:1 ratio, 170 subjects/arm, a total of 680 subjects.
All subjects will take a maximum of 6 tablets daily and will be up-titrated weekly in 2-mg increments to their randomized dose.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Percent Change in the 28-day Seizure Frequency From Baseline to the End of the Double-blind Phase (Titration and Maintenance Phases)
Time Frame: Baseline (Pre-randomization) through Week 19
|
Seizure frequency per 28 days was derived from the information recorded in the subject diaries.
|
Baseline (Pre-randomization) through Week 19
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Responder Rate
Time Frame: Baseline (Pre-randomization) through Week 19
|
The responder rate for the Full ITT Analysis Set from the maintenance LOCF (Last Observation Carried Forward).
A responder was a subject who had a 50 percent or greater reduction in seizure frequency per 28 days from the Pre-randomization phase.
|
Baseline (Pre-randomization) through Week 19
|
Percent Change in the 28-day Complex Partial Plus Secondarily Generalized Seizure Frequency From Baseline to the End of the Double-blind Phase (Titration and Maintenance Phases)
Time Frame: Baseline (Pre-randomization) through Week 19
|
Percent Change in the Seizure frequency per 28 days was derived from the information recorded in the subject diaries.
|
Baseline (Pre-randomization) through Week 19
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Study Director: David Squillacote, M.D., Eisai Inc.
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Maguire M. Response to "Perampanel and pregnancy: Could experience be a gloomy lantern that does not even illuminate its bearer?". Epilepsy Behav. 2022 Apr;129:108654. doi: 10.1016/j.yebeh.2022.108654. Epub 2022 Mar 16. No abstract available.
- French JA, Gil-Nagel A, Malerba S, Kramer L, Kumar D, Bagiella E. Time to prerandomization monthly seizure count in perampanel trials: A novel epilepsy endpoint. Neurology. 2015 May 19;84(20):2014-20. doi: 10.1212/WNL.0000000000001585. Epub 2015 Apr 15.
- Rosenfeld W, Conry J, Lagae L, Rozentals G, Yang H, Fain R, Williams B, Kumar D, Zhu J, Laurenza A. Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study. Eur J Paediatr Neurol. 2015 Jul;19(4):435-45. doi: 10.1016/j.ejpn.2015.02.008. Epub 2015 Mar 5.
- Steinhoff BJ, Ben-Menachem E, Ryvlin P, Shorvon S, Kramer L, Satlin A, Squillacote D, Yang H, Zhu J, Laurenza A. Efficacy and safety of adjunctive perampanel for the treatment of refractory partial seizures: a pooled analysis of three phase III studies. Epilepsia. 2013 Aug;54(8):1481-9. doi: 10.1111/epi.12212. Epub 2013 May 10.
- Krauss GL, Serratosa JM, Villanueva V, Endziniene M, Hong Z, French J, Yang H, Squillacote D, Edwards HB, Zhu J, Laurenza A. Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology. 2012 May 1;78(18):1408-15. doi: 10.1212/WNL.0b013e318254473a. Epub 2012 Apr 18.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2008
Primary Completion (Actual)
August 1, 2009
Study Completion (Actual)
January 1, 2010
Study Registration Dates
First Submitted
June 17, 2008
First Submitted That Met QC Criteria
June 17, 2008
First Posted (Estimate)
June 18, 2008
Study Record Updates
Last Update Posted (Estimate)
January 21, 2016
Last Update Submitted That Met QC Criteria
December 17, 2015
Last Verified
November 1, 2015
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- E2007-G000-306
- 2007-006169-33 (EudraCT Number)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Refractory Partial Seizures
-
Lundbeck LLCCompletedAdult Refractory Complex Partial SeizuresUnited States
-
Bial - Portela C S.A.CompletedEfficacy and Safety of Eslicarbazepine Acetate as Adjunctive Therapy for Refractory Partial SeizuresRefractory Partial EpilepsyPortugal
-
Eisai Inc.CompletedRefractory Partial SeizuresUnited States, Chile, Brazil, Canada, Mexico, Argentina
-
Eisai Inc.CompletedRefractory Partial SeizuresUnited States, France, Germany, Italy, United Kingdom, Belgium, Israel, South Africa, Finland, Russian Federation, Austria, Netherlands, Sweden, India
-
Eisai Co., Ltd.CompletedRefractory Partial SeizuresJapan
-
University of South AlabamaWithdrawnRefractory Partial SeizuresUnited States
-
Eisai Co., Ltd.CompletedRefractory Partial SeizuresJapan
-
Eisai Inc.TerminatedRefractory Partial Onset SeizuresUnited States
-
ValexfarmCompletedEpilepsy | Complex Partial Seizures | Simple Partial Seizures | Partial Seizures With Secondary GeneralizationRussian Federation
-
Lundbeck LLCCompletedInfantile Spasms | Refractory Complex Partial Seizures in Adults
Clinical Trials on perampanel
-
Eisai Inc.Completed
-
Kimford Jay MeadorEisai Inc.Recruiting
-
Eisai Inc.CompletedRefractory Partial SeizuresUnited States, Chile, Brazil, Canada, Mexico, Argentina
-
Eisai Inc.CompletedRefractory Partial SeizuresUnited States, France, Germany, Italy, United Kingdom, Belgium, Israel, South Africa, Finland, Russian Federation, Austria, Netherlands, Sweden, India
-
Weill Medical College of Cornell UniversityEisai Inc.Completed
-
National Taiwan University HospitalCompleted
-
University Health Network, TorontoDystonia Study GroupCompletedCervical DystoniaUnited States, Canada
-
Hospices Civils de LyonCompleted
-
Eisai Inc.CompletedEpilepsyBelgium, France, United States, Czech Republic, Estonia, Latvia, Spain, United Kingdom, Lithuania, Germany, Australia, Finland, Netherlands, Sweden
-
Eisai Inc.Completed