- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00878085
Functional Magnetic Resonance Imaging (fMRI) and Robot-Assisted Practice of Activities of Daily Living
February 3, 2014 updated by: Michelle J. Johnson, Medical College of Wisconsin
fMRI and Robot-Assisted Practice of Activities of Daily Living
The investigators will study motor recovery after robot-assisted therapy after stroke.
A small clinical trial will be conducted to quantify the central nervous system changes associated with robotic or standard training, and identify trends across high and low responders in terms of patterns of change in cortical activity and type of white matter connectivity.The investigators hypothesize that robot training will lead to larger improvements as compared to standard occupational therapy.
The investigators hypothesize that high responders to the robot training will have reduced compensatory activation in the bilateral area and will connectivity in the motor tracts.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Robot-assisted therapy is on the cutting edge of stroke rehabilitation and is a therapy method that promises to improve the lives of persons with disabilities due to stroke.
Preliminary studies using these tools provide mixed evidence for their effectiveness and reveal limitations.
For example, inconsistent carryover of motor gains to real life activities of daily living (ADLs) is seen.
Therefore, it is still not clear what treatment strategies maximize functional outcomes on ADLs.
There is a need to study the stroke recovery process and to understand how to optimize robot-assisted therapies in order to enhance patient rehabilitation and improve functional outcomes.
Imaging techniques such as functional Magnetic Resonance Imaging (fMRI) and Diffusion Tensor Imaging (DTI) can assist us in understanding the stroke recovery process, in determining who may benefit from robot-assisted training, and in defining how training induced functional cortical changes occur after robot training.
We propose to conduct an interventional study plus control to assess the effectiveness of four weeks of robot-assisted practice of tasks with skilled functional tasks that involve reaching and grasping activities similar to real activities.
We will examine the process of recovery for low-to-moderate functioning stroke survivors with chronic disability.
We will assess the ability of active-assisted reaching and grasping training to effect immediate gains and long-term functional improvements.
Further, using fMRI and DTI, we plan to associate changes seen in motor impairment levels and functional task performance levels with white matter injuries and connectivity and changes in oxygen utilization in the motor cortex as well as other areas of the brain.
Our short-term aims are to, i) assess short-term functional gains after practice of skilled reaching and grasping tasks; ii) assess maintenance of these improvements; iii) quantify the neuronal changes associated with short-term gains, and iv) identify trends across high and low responders in terms of patterns of change in cortical activity and type of white matter connectivity.
In the long-term, we hope to improve understanding of the process of ADL functional recovery after stroke and optimize robot-training strategies leading to cerebral plasticity.
We also hope to determine how lesion characteristics affect changes seen in function, white matter connectivity, and cortical activity.
By, accomplishing these aims, we hope to improve upper extremity function after stroke and reduce disability.
Study Type
Interventional
Enrollment (Anticipated)
61
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Wisconsin
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Milwaukee, Wisconsin, United States, 53226
- Medical College of Wisconsin
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Milwaukee, Wisconsin, United States, 53295
- Clement J Zablocki VA
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
30 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Description
Inclusion Criteria:
Stroke:
- 30 to 85 years
- Right-handed (evaluated with handedness survey)
- suffered a unilateral ischemic stroke in the motor control area, which resulted in hemiparesis of the arm (confirmed by medical data),
- at least 6-months post-stroke
- residual movement at least (a) 15 degree shoulder flexion or adduction, (b) 15 degree active elbow flexion and extension
- not claustrophobic
- not depressed (as measured depression survey)
- able to use the scanner, i.e., passes the fMRI screening survey
- able to understand the instructions and complete the tracking tasks Control
- older than 20 years
- Right-handed (evaluated with survey)
- not claustrophobic
- able to use the scanner, i.e., passes the fMRI screening survey
- able to understand the instructions and complete the tracking tasks
- no history of neurological disorders --not depressed (as measured depression survey)
Exclusion Criteria:
Stroke:
- brain stem, stroke
- pre-existing neurological or psychiatric disorders
- Spasticity >3 at elbow or fingers on Ashworth
- demonstrated visuospatial, language or attention deficits of a severity that prevents understanding the task
- shoulder pain or joint pain during movements
- synkinetic movements or mirror movements
- decline to participate
- will not comply with full protocol
- pregnant
- allergic to goretex and conductivity gel
Control
- decline to participate
- will not comply with full protocol
- pregnant
- allergic to goretex and conductivity gel
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 1
Robot Therapy with activities of daily living (ADLs)
|
3x a week for 4 weeks
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Active Comparator: 2
Standard Occupational Therapy
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3x a week for 4 weeks
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Clinical Measures: Fugl-Meyer (Motor control), Functional Hand Evaluation (ADL), Jebsen Taylor
Time Frame: Pre (2x) , Post, Follow-Up
|
Pre (2x) , Post, Follow-Up
|
Biomechanical:Movement Time, Grasp Aperture, Movement Smoothness
Time Frame: Pre (2x), Post, Follow-up
|
Pre (2x), Post, Follow-up
|
Imaging Measures: BOLD response (activation), Laterality Index, Fractional Anisotropy, Fiber Density Index
Time Frame: Pre (1x), Post, Follow-up
|
Pre (1x), Post, Follow-up
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Clinical Measures: Joint ROM, MMT, Spasticity
Time Frame: Pre(2x), Post, Follow-up
|
Pre(2x), Post, Follow-up
|
Clinical Measures: Pain, Exertion
Time Frame: During Therapy
|
During Therapy
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Collaborators
Investigators
- Study Chair: Michel Torbey, MD, Medical College of Wisconsin
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2008
Primary Completion (Actual)
June 1, 2013
Study Completion (Actual)
June 1, 2013
Study Registration Dates
First Submitted
March 23, 2009
First Submitted That Met QC Criteria
April 7, 2009
First Posted (Estimate)
April 8, 2009
Study Record Updates
Last Update Posted (Estimate)
February 4, 2014
Last Update Submitted That Met QC Criteria
February 3, 2014
Last Verified
February 1, 2014
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HR
- NIH 1K25NS058577 - 01A1
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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