Correlation Analysis Between Brain Lesions and Sensorimotor Impairments in Individuals With Stroke (Preliminary Study)

The objective of the preliminary study is:

1. To identify correlations between brain lesions and sensorimotor impairments in stroke.
2. To identify possible patterns between brain lesions and sensorimotor impairments that might increase our understanding in stroke recovery and guide further tailor-based neuro-rehabilitation

Study Overview

• Status: Completed
• Conditions: Stroke
• Intervention / Treatment: Other: Device: 3T scanner with MRI-compatible robot

Detailed Description

The purpose of this study is to investigate arm and hand function after stroke and how the location of the brain lesion affects arm and hand function. We are hoping to collect data in the form of assessments what you feel and how your arm moves, surveys about activities in daily life and well-being, and we will perform 1 Magnetic Resonance Imaging (MRI) scan. MRI scans are loud but painless; nothing is injected. With MRI, we collect images from the brain.

• Study Type: Observational
• Enrollment (Actual): 16

Contacts and Locations

Study Locations

• United States
  • Minnesota
    • Minneapolis, Minnesota, United States, 55455
      • University of Minnesota Medical Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Healthy Control Group Stroke patient subjects

Description

Inclusion Criteria:

• Inclusion criteria for healthy subjects are:

  • medically stable;
  • 18 - 99 years of age;
  • able to hear the instructions given during the study

Inclusion criteria for stroke patients are:

• at least 6 months post-stroke;
• medically stable;
• 18 - 99 years of age;
• subcortical or cortical infarct confirmed with MRI;
• Mini-mental State Exam > 24/30 (Folstein et al., 1975);
• able to hear the instructions given during the study;
• able to comprehend the instructions given during the study;
• able to commit time to participate in a 6-12-weeks rehabilitation program

Exclusion Criteria:

Exclusion criteria for healthy subjects are:

• having ever experienced a stroke or another brain injury or illness related to the brain that has lasting effects or effects experienced at the moment of recruitment;
• severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt;
• contractures in tested arm that hinder persons from keeping the outstretched arm in a relaxed position;
• interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);
• exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc);
• pregnant or nursing mother;
• adults lacking capacity to consent

Exclusion criteria for stroke patients are:

• insular or cerebellar infarcts/brain lesions;
• unilateral spatial neglect, identified by a standard neuropsychological assessment (Bell's test (score/35, Gauthier et al., 1989);
• aphasia;
• apraxia (TULIA, Vanbellingen et al., 2011);
• severe sensory impairments such that different movements of the finger, hand or wrist are not reliably felt;
• contractures in the hemiplegic arm that hinder patients from keeping the outstretched arm in a relaxed position;
• interfering comorbidities (e.g. fracture, cancer, peripheral neuropathy);
• patients currently receiving therapy for their hemiplegic arm, the latter in order to avoid confounding treatment effects;
• exhibit contra-indications to enter the magnetic field of the 3T (pacemakers, metal parts in the body etc);
• pregnant or nursing mother;
• adults lacking capacity to consent

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Stroke patients; 20 patients who are at least 6 months post stroke. Device: 3T scanner with MRI-compatible robot	Other: Device: 3T scanner with MRI-compatible robot
Healthy volunteers; 80 age-matched healthy volunteers	Other: Device: 3T scanner with MRI-compatible robot

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Structural and Functional Imaging	Identify correlations between brain lesions and sensimotor impairments in stroke	1 week
Identify Possible Patterns	Identify possible patterns between brain lesions and senosrimotor impairments that might increase our understanding in stroke recovery and guide further tailor-based neuro-rehabilitation	1 week

Collaborators and Investigators

• Sponsor: University of Minnesota
• Investigators: Principal Investigator: Anne Van de Winckel, PhD, MS, PT, University of Minnesota

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2015
• Primary Completion (Actual): September 23, 2016
• Study Completion (Actual): September 23, 2016

Study Registration Dates

• First Submitted: May 29, 2015
• First Submitted That Met QC Criteria: June 4, 2015
• First Posted (Estimate): June 8, 2015

Study Record Updates

• Last Update Posted (Actual): March 11, 2020
• Last Update Submitted That Met QC Criteria: March 9, 2020
• Last Verified: March 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke
• Other Study ID Numbers: 1503M66381