- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00890578
HISTOACRYL: A Study of Its Efficacy in Final Scar Formation
It is Our Intent to Conduct a Prospective Randomized Controlled Trial Examining the Use of Histoacryl© in the Closure of Surgical Incisions in Comparison to Subcuticular Suture and to Dermabond©.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Florida
-
Jacksonville, Florida, United States, 32224
- Mayo Clinic Florida
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
1) and 2): Reduction Mammoplasty or mastopexy patients: Patients who present to the plastic surgery clinic and are scheduled for breast procedures will be recruited and consented by a clinical studies co-ordinator. This will include patients undergoing a standard Wise pattern reduction mammoplasty (reduction and lift) or a standard Wise pattern mastopexy (lift only). See exclusion criteria below.
1) and 2): Abdominoplasty or panniculectomy patients: Patients who present to the plastic surgery clinic and are scheduled for abdominal procedures will be recruited and consented by a clinical studies coordinator. See exclusion criteria below.
Description
Inclusion Criteria:
- Age: Younger than 21
- Gender: Females only. Given the nature of the procedures, as well as our clinical experience, we cannot anticipate recruiting enough male patients to be able to evaluate them as a subgroup. Since there may be differences in distributions of measures, to keep the groups more homogeneous we plan to recruit only females from the outset. Having either:
Reduction Mammoplasty or mastopexy patients:
- Patients who present to the plastic surgery clinic and are scheduled for breast procedures will be recruited and consented by a clinical studies co-ordinator.
- This will include patients undergoing a standard Wise pattern reduction mammoplasty (reduction and lift) or a standard Wise pattern mastopexy (lift only). See exclusion criteria below.
Abdominoplasty or panniculectomy patients:
- Patients who present to the plastic surgery clinic and are scheduled for abdominal procedures will be recruited and consented by a clinical studies coordinator. See exclusion criteria below.
Exclusion Criteria:
- Though women of childbearing age will be allowed to participate in this study, no pregnant patients will be enrolled.
Patients with any factors that may have an adverse effect on wound healing:
- previous hypertrophic scars or keloid
- known vitamin C deficiency
- known zinc deficiency
- smoking
- steroid use
- known connective tissue disorder
- hypoalbuminemia
- any factor not listed that the attending consultant seeing the patient feels would adversely effect wound healing.
- Patients who have a known sensitivity to adhesives
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
1-abdominal
half abdominal surgeries (20 patients out of 40)
|
surgical closure
Other Names:
|
2-breast
half breast surgeries (20 out of 40)
|
surgical closure
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Comparison of Histoacryl© to Dermabond© is lacking. Investigation of Histoacryl© in direct comparison to Dermabond© as well as to suture.
Time Frame: 1 year
|
1 year
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Galen Perdikis, M.D., Mayo Clinic
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 08-007642
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Surgical Incisions
-
Advanced Medical Solutions Ltd.CompletedSurgical IncisionsUnited States
-
Peking UniversityBeijing Municipal Science & Technology CommissionUnknownSurgical Approach & IncisionsChina
-
The Metis FoundationCompletedIncisions, SurgicalUnited States
-
Stony Brook UniversityWithdrawn
-
Ethicon, Inc.CompletedSurgical IncisionsBelgium, Germany, Sweden, United Kingdom
-
University of Toledo Health Science CampusUnknownSurgical IncisionsUnited States
-
OptMed, Inc.CompletedTraumatic Lacerations or Surgical IncisionsUnited States
-
Centre Hospitalier Universitaire de NiceAssistance Publique Hopitaux De Marseille; Fondation Lenval; Centre Hospitalier...Completed
-
Neodyne Biosciences, Inc.CompletedPost Surgical Incisions From Abdominoplasty ProceduresUnited States
-
Oslo University HospitalCompletedSkin Closure of Surgical Incisions by Tissue Glue vs SutureNorway
Clinical Trials on adhesive to suture
-
University of California, DavisCompletedSubjects Undergoing Surgical Procedure of the SkinUnited States
-
Dr. Stephanie KrauseCompleted
-
Fondation Hôpital Saint-JosephCompleted
-
Rubino Ob-Gyn GroupUnknown
-
Rady Children's Hospital, San DiegoUnknownCyst of Face, Neck or Shoulder | Pilomatrixoma of Face, Neck or ShoulderUnited States
-
The University of Texas Health Science Center,...TerminatedEyelid LacerationUnited States
-
Mayo ClinicTerminatedCardiovascular DiseaseUnited States
-
Rothman Institute OrthopaedicsEnrolling by invitation
-
Hospital Sao JoaoUniversidade do PortoCompletedMediolateral Episiotomy After DeliveryPortugal
-
Chinese University of Hong KongNot yet recruiting