Clinical Pharmacists Role in the Management of Hypertension in Jordan

Background: studies have demonstrated the crucial role of clinical pharmacists as integrated part of heath care team. Not only in Jordan but also in the Middle East region, clinical pharmacy practice is not well established. This current study is the first to evaluate physicians - pharmacists' collaborative approach to uncontrolled blood pressure in Jordan and the Middle East.

Study Overview

• Status: Completed
• Conditions: Hypertension
• Intervention / Treatment: Other: pharmaceutical care services

Detailed Description

Objective: this study aimed to evaluate clinical pharmacists' role in the management of uncontrolled hypertensive patients in Jordan. Design: single blinded randomized controlled clinical trial. Patients: 253 patients with uncontrolled hypertension specified as higher blood pressure readings than the recommended goals by the seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure (JNC VII) at the time of enrollment.

Interventions: patients were randomly allocated to an intervention or control group: 130 and 123 patients, respectively. Patients in both arms were followed up for 6 months. In the intervention group, patients were managed by physician-clinical pharmacist team. In the control group, patients were managed by physician(s) only and were not provided pharmaceutical care services.

• Study Type: Interventional
• Enrollment (Actual): 266
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Jordan
  • Amman, Jordan, 13046
    • family medicine clinic JUH

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 88 years (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients with uncontrolled BP, receiving 0-3 antihypertensive drugs with no change in the regimen or dose within the past 3 month.

Exclusion Criteria:

• Patients with hypertensive urgency or emergency with BP more than (180/110).
• Patients with recent stroke or myocardial infraction (within past 6 months).
• Patients with Class III or IV Chronic heart Failure (CHF).
• Patients with Unstable angina.
• Patients with Serious renal or hepatic disease.
• Pregnant patients.
• Patients with Dementia or cognitive impairment.
• If the patient is unable to provide informed written consent.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Health Services Research
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Active Comparator: intervention group; physician-pharmacist teamwork	Other: pharmaceutical care services; Patients treatment related problems and therapeutic needs or complains identified by clinical pharmacist and managed collaboratively by both pharmacist and the physician.
No Intervention: control; physician only team

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
percentage of patients who achieved blood pressure goals specified by the JNC VII at each group	defined a goal to be achieved if the systolic blood pressure fell below 140 mm Hg and the diastolic blood pressure fell below 90 mm Hg. Or systolic blood pressure fell below 130 mm Hg and the diastolic blood pressure fell below 80 mm Hg if patient was diabetic.	6 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
mean reductions in both systolic and diastolic blood pressure readings	mean reductions in systolic blood pressure (Systolic blood pressure at enrollment - Systolic blood pressure last follow up visit) and diastolic BP (Diastolic blood pressure at enrollment - Diastolic blood pressure last follow up visit) for both study groups	6 months

Collaborators and Investigators

• Sponsor: University of Jordan
• Collaborators: Jordan Hospital
• Investigators: Principal Investigator: Eman Hammad, MSc, University of Jordan/ Faculty of Pharmacy; Study Director: Abla Al bsoul, PhD, University of Jordan/ Faculty of Pharmacy

Study record dates

Study Major Dates

• Study Start: March 1, 2009
• Primary Completion (Actual): November 1, 2009
• Study Completion (Actual): November 1, 2009

Study Registration Dates

• First Submitted: March 2, 2010
• First Submitted That Met QC Criteria: March 2, 2010
• First Posted (Estimate): March 3, 2010

Study Record Updates

• Last Update Posted (Estimate): April 7, 2010
• Last Update Submitted That Met QC Criteria: April 6, 2010
• Last Verified: March 1, 2009

More Information

Terms related to this study

• Keywords: Uncontrolled blood pressure
• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension
• Other Study ID Numbers: JU8071383