Nutrition and Physical Activity for Obesity (PRONAF)

October 2, 2019 updated by: Pedro JoseBenito Peinado, Universidad Politecnica de Madrid

Nutrition and Physical Activity Programs for Obesity Treatment (PRONAF)

At the present time, scientific consensus exists on obesity multifactorial etiopatogenia. As well, professionals and researchers agree that the treatment must approach several scopes, such as dietetic, physical activity, pharmacologic and surgical. These two last ones should not be the first election and must be reserved for those cases of morbid obesities or in case the previous ones have failed. The combination of diet and exercise is still not sufficiently studied, in special, the addition of strength training, as we propose in this project, for which established intervention protocols do not exist, and that could suppose an additional benefit in the reduction of risk factors.

Therefore, the objectives that we aim in this project are enumerated below:

  • To discover which are the most effective training protocols and to determine what type of exercise combined with nutrition is more appropriate for obesity intervention programs.
  • To establish the relationship between markers related with cardiovascular risk (adopokines and lipid profile) and the different intervention protocols proposed.
  • To describe the influence of nine genetic polymorphisms (selected by their relationship with the energy expense and the physical yield) on the effect of different training protocols.
  • To determine how important is body composition (fat mass and muscle mass mainly) in total daily energy expenditure.
  • To establish rules of nutritional and exercise intervention that can be applied in public and private training centers. If the proposed objectives are fulfilled, this would contribute to an improvement in patients health in long term, along with an enormous saving in public health. Therefore, the purpose of this project is to propose new lines of intervention in overweight and obese adults that, until now, little have been investigated. This way, resistance training is proposed in combination with cardiovascular training and endocrinologic treatment. It fits to emphasize that, as far as we know, it is the first project of these characteristics, that puts in touch the public and private sector (hospitals, universities and fitness area), to establish standardized relations protocols to allow a close pursuit of obese patients.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

240

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Spain
      • Madrid, Spain, 28080
        • Pedro J. Benito Peinado
      • Madrid, Spain, 28939
        • Facultad de Ciencias de la Actividad Física y del Deporte

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 50 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

For Overweight phase:

Inclusion Criteria:

  • Volunteers: men and women from Comunidad de Madrid (Zone 5 of Health System) who sign the informed consent.
  • Ages 18 - 50 years old.
  • Pre-menopausal.
  • Body mass index (BMI) of 25 - 30 kg•m-2 (both included).
  • Able to attend exercise classes 3 times per week (Monday, Wednesday and Friday). No plans for excessive travel. No plans to move from area for study period (January 2010 - June 2010, both included).
  • Able to follow the nutritional treatment (avoid medication or substances known to interfere with body weight regulation, including anti-depressive medication, diuretics, etc., 15 days before study starts).
  • Willing to not participate in other formal or informal weight loss program during the period of the study.
  • Sedentary (less than once a week of training or two hours of physical activity class).

Exclusion Criteria:

  • Smoking within six months, or use of tobacco or nicotine product.
  • Women with irregular menstrual cycle (except with hormone therapy).
  • Following a weight loss diet, vegetarians or food restriction due to religion.
  • Self-reported weight loss or gain >5% in past 6 months.
  • Are not pregnant, or haven´t been in the past six months. Are not currently nursing or planning to become pregnant during the study period (year 2010).
  • Need a special diet by associated disease (celiac disease or chronic renal insufficiency).
  • Have metabolic syndrome or fulfill three or more of the following criteria: abdominal obesity (waist diameter > 102 cm in men and > 88 cm in women), blood pressure ≥ 130/85 mm Hg, basal glycemia ≥ 110 mg/dL, triglyceride level > 150 mg/dL and C-HDL < 40 mg/dL in women and < 50 mg/dL in men.
  • Diabetes.
  • Anemia (Hct < 37%).
  • Uncontrolled high blood pressure (Systolic > 160 mm Hg or diastolic > 100 mm Hg in rest). Current use of more than one anti-hypertensive medication.
  • Substance abuse (drugs, alcohol…). High or moderate consumes of alcohol. More than 2 glasses to the day of any alcoholic substance. Current use of diuretics, beta blockers, steroids or blood thinners.
  • Contraindication to exercise. Alterations, syndromes or diseases detected by electrocardiogram (EKG) o echocardiography. Have injuries o pathologies of the locomotive apparatus that prevent the correct execution of the exercises of the program. Any illness that would prevent participation in a moderate-intense exercise program.
  • Have had cancer in the past 5 years, except skin cancer.
  • Coronary artery disease, liver disease, pulmonary disease, renal disease or other systemic disorders.
  • History or evidence of cardiovascular disease, alterations, syndromes or other mayor chronic illness. Have history of heart disease, heart attacks or heart surgery.
  • Have any illness known to interfere with body weight loss: clinical depression, eating disorder (anorexia, bulimia, etc.), psychological diseases (schizophrenia, etc.), dementia or cognitive function decreased, hypothyroidism no controlled or history of genetic or chromosomal disorder.
  • Have had bariatric surgery or stomach bypass surgery.
  • Gross physical impairment.
  • Blindness or retinopathy.

For Obese phase:

Inclusion Criteria:

  • Volunteers: men and women from Comunidad de Madrid (Zone 5 of Health System) who sign the informed consent.
  • Ages 18 - 50 years old.
  • Pre-menopausal.
  • Body mass index (BMI) of 30 - 35 kg•m-2 (both included).
  • Able to attend exercise classes 3 times per week (Monday, Wednesday and Friday). No plans for excessive travel. No plans to move from area for study period (January 2011 - June 2011, both included).
  • Able to follow the nutritional treatment (avoid medication or substances known to interfere with body weight regulation, including anti-depressive medication, diuretics, etc., 15 days before study starts).
  • Willing to not participate in other formal or informal weight loss program during the period of the study.
  • Sedentary (less than once a week of training or two hours of physical activity class).

Exclusion Criteria:

  • Smoking within six months, or use of tobacco or nicotine product.
  • Women with irregular menstrual cycle (except with hormone therapy).
  • Following a weight loss diet, vegetarians or food restriction due to religion.
  • Self-reported weight loss or gain >5% in past 6 months.
  • Are not pregnant, or haven´t been in the past six months. Are not currently nursing or planning to become pregnant during the study period (year 2011).
  • Need a special diet by associated disease (celiac disease or chronic renal insufficiency).
  • Have metabolic syndrome or fulfill three or more of the following criteria: abdominal obesity (waist diameter > 102 cm in men and > 88 cm in women), blood pressure ≥ 130/85 mm Hg, basal glycemia ≥ 110 mg/dL, triglyceride level > 150 mg/dL and C-HDL < 40 mg/dL in women and < 50 mg/dL in men.
  • Diabetes.
  • Anemia (Hct < 37%).
  • Uncontrolled high blood pressure (Systolic > 160 mm Hg or diastolic > 100 mm Hg in rest). Current use of more than one anti-hypertensive medication.
  • Substance abuse (drugs, alcohol…). High or moderate consumes of alcohol. More than 2 glasses to the day of any alcoholic substance. Current use of diuretics, beta blockers, steroids or blood thinners.
  • Contraindication to exercise. Alterations, syndromes or diseases detected by electrocardiogram (EKG) o echocardiography. Have injuries o pathologies of the locomotive apparatus that prevent the correct execution of the exercises of the program. Any illness that would prevent participation in a moderate-intense exercise program.
  • Have had cancer in the past 5 years, except skin cancer.
  • Coronary artery disease, liver disease, pulmonary disease, renal disease or other systemic disorders.
  • History or evidence of cardiovascular disease, alterations, syndromes or other mayor chronic illness. Have history of heart disease, heart attacks or heart surgery.
  • Have any illness known to interfere with body weight loss: clinical depression, eating disorder (anorexia, bulimia, etc.), psychological diseases (schizophrenia, etc.), dementia or cognitive function decreased, hypothyroidism no controlled or history of genetic or chromosomal disorder.
  • Have had bariatric surgery or stomach bypass surgery.
  • Gross physical impairment.
  • Blindness or retinopathy.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: PREVENTION
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Nutrition
This groups will follow a diet.
Other: Exercise
Different groups will carry out different exercise protocols during 16 weeks under the same nutritional intervention.
EXPERIMENTAL: Nutrition + resistance training
In this group, nutrition and resistance training will be combined.
Other: Exercise
Different groups will carry out different exercise protocols during 16 weeks under the same nutritional intervention.
EXPERIMENTAL: Nutrition + aerobic training
In this group nutrition and aerobic training will be combined.
Other: Exercise
Different groups will carry out different exercise protocols during 16 weeks under the same nutritional intervention.
EXPERIMENTAL: Nutrition + mixed training
In this group the nutrition will be combined with 50% of resistance training plus 50% of aerobic training.
Other: Exercise
Different groups will carry out different exercise protocols during 16 weeks under the same nutritional intervention.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Body composition
Time Frame: After 16 weeks of intervention
After 16 weeks of intervention
Health status
Time Frame: After 16 weeks of intervention
After 16 weeks of intervention
Cardiorespiratory fitness
Time Frame: After 16 weeks of intervention
After 16 weeks of intervention

Secondary Outcome Measures

Outcome Measure
Time Frame
Quality of life
Time Frame: After 16 weeks of intervention
After 16 weeks of intervention

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universidad Politecnica de Madrid

Collaborators

Universidad Complutense de Madrid
Hospital Universitario La Paz
Hospital Universitario Marqués de Valdecilla

Investigators

  • Principal Investigator: Pedro J Benito, PhD, Department of Health and Human Performance, Universidad Politécnica de Madrid

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2009

Primary Completion (ACTUAL)

January 1, 2010

Study Completion (ACTUAL)

December 1, 2011

Study Registration Dates

First Submitted

April 30, 2010

First Submitted That Met QC Criteria

May 4, 2010

First Posted (ESTIMATE)

May 5, 2010

Study Record Updates

Last Update Posted (ACTUAL)

October 4, 2019

Last Update Submitted That Met QC Criteria

October 2, 2019

Last Verified

October 1, 2019

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • PRONAF

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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