The Study of Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder

The Study of Morning and Nocturnal Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder

One of the main points in the biological trends is, the circadian rhythm and disturbance in this cycle, which cause mood disorders and irregularity in this bio clock, to get depression. The pineal gland with the precise regulation of circadian rhythm of melatonin regulates the brain haemostasis. The abnormal function of this gland gives rise to psychiatric disorders.

In the period of youth and early of middle-age cause biochemical changes and disturbance in biorhythm including melatonin secretion.

This process can change the peak of melatonin phase. In addition, a decrease in the level of serum melatonin, can change the function of immune system of depressed patients. This function facilitates the process of cancerous cell formation and tumor growth.

With respect to the conflicting results and that the positive and negative roles of melatonin in the creation of depression is unknown, the aim of this study was to compare the morning and nocturnal serum melatonin rhythm levels in the patients with Major Depressive Disorder. The second purpose was to measure the morning and nocturnal serum melatonin levels in the depressed and healthy men and women.

Study Overview

• Status: Completed
• Conditions: Major Depressive Disorder

• Study Type: Observational
• Enrollment (Anticipated): 92

Contacts and Locations

Study Locations

• Iran, Islamic Republic of
  • Isfahan, Iran, Islamic Republic of, 81989
    • Shahnaz Khaleghipour

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 22 years to 48 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

The individuals were chosen who referred to the industrial medical unit of one of big company.

Description

Inclusion Criteria:

1. age: 22-48 years old
2. gender: male, female
3. who got a depressive score above 20, were included in the depressed group
4. those who obtained a depressive score below 9, were chosen and they were included in the healthy control group.
5. the healthy control group to match to the depressed patients for education, social occasion, occupational and economical situation.
6. the depression disorder was confirmed on the basis of the DSM criteria

Exclusion Criteria:

1. present or past psychiatric
2. physical diagnoses
3. drug consumption
4. use of narcotic substances
5. physical and psychosomatic disorders
6. the stressor
7. malfunction of thyroid gland
8. shift working

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Major Depression Disorder; This study is analytical cross-sectional and randomized. Two groups of depressed patients and healthy subjects were selected.The individual were submitted to a medical examination, and responded to the Beck depression inventory (BDII-II). Those, who got a score above 20, were included in the depressed group. Among this group, 50 patients were chosen randomly. those who obtained a depressive score below 9, 50 of them were chosen and they were included in the healthy group. The control group was chosen to match to the depressed patients for education, social occasion, occupational and economical situation. All of the subjects were interviewed psychiatrically, and the depression disorder was confirmed on the basis of the DSM criteria. eight out of 50 depressed patients were excluded from the study due to suffering from other psychiatric disorders .

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Depression status(measured by Beck depression inventory (BDII-II))	2weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Measurements of morning and nocturnal melatonin levels by ELISA kit (cat no. RE54021) from the IBL-Hamburg.	The blood vein (5 milliliters) was taken from two groups at 8:00 am on a particular day. At the end of the same day and 24:00 h, the subjects were retaken the blood samples under the dim light.	1 week

Collaborators and Investigators

• Sponsor: Science & Research Islamic Azad University Branch Khozestan
• Investigators: Principal Investigator: Shahnaz Khaleghipour, PhD, Science and Research Branch Islamic Azad University Khozestan

Publications and helpful links

General Publications

• Khaleghipour S, Masjedi M, Ahade H, Enayate M, Pasha G, Nadery F, Ahmadzade G. Morning and nocturnal serum melatonin rhythm levels in patients with major depressive disorder: an analytical cross-sectional study. Sao Paulo Med J. 2012;130(3):167-72. doi: 10.1590/s1516-31802012000300006.

Study record dates

Study Major Dates

• Study Start: August 1, 2010
• Primary Completion (Actual): October 1, 2010
• Study Completion (Actual): October 1, 2010

Study Registration Dates

• First Submitted: May 10, 2011
• First Submitted That Met QC Criteria: May 19, 2011
• First Posted (Estimate): May 20, 2011

Study Record Updates

• Last Update Posted (Estimate): May 20, 2011
• Last Update Submitted That Met QC Criteria: May 19, 2011
• Last Verified: August 1, 2009

More Information

Terms related to this study

• Keywords: Depression; Melatonin; Serum; Depressive disorder, major; Periodicity
• Additional Relevant MeSH Terms: Behavioral Symptoms; Mental Disorders; Pathologic Processes; Mood Disorders; Depression; Depressive Disorder; Disease; Depressive Disorder, Major
• Other Study ID Numbers: 9460 (CTEP); CCT-NAPN-21087