Gut Hormones After Meal Ingestion in Males Versus Females

September 29, 2014 updated by: Bo Ahren, Lund University

Effects of Varying Meal Size on Gut Hormone and Islet Hormone Secretion in Males Versus Females

The study hypothesis is that the release of gut hormones is increased proportionally to caloric load in each meal. Three different meals with different meal size will therefore be served and gut hormones determined.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

In healthy males and females, meals with 511, 743 and 1034 kcal will be given orally. Samples will be taken during the following 300 min and gut hormones (glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1) will be determined along with insulin and glucagon levels.

Study Type

Interventional

Enrollment (Actual)

24

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Sweden
      • Lund, Sweden, 221 84
        • Department of Clinical Sciences Lund, Lund University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 30 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Healthy status

Exclusion Criteria:

  • Diabetes
  • Liver disease
  • kidney disease
  • thyroid disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: NON_RANDOMIZED
  • Interventional Model: FACTORIAL
  • Masking: NONE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Healthy males
Meal ingestion in healthy males
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal
EXPERIMENTAL: Healthy females
Meal ingestion in healthy females
Other: Meal ingestion
Meal 511 kcal, meal 743 kcal or meal 1034 kcal

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Release of gut hormones
Time Frame: 300 min
300 min

Secondary Outcome Measures

Outcome Measure
Time Frame
Insulin secretion
Time Frame: 300 min
300 min

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Lund University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2011

Primary Completion (ACTUAL)

February 1, 2014

Study Completion (ACTUAL)

June 1, 2014

Study Registration Dates

First Submitted

May 31, 2011

First Submitted That Met QC Criteria

June 2, 2011

First Posted (ESTIMATE)

June 6, 2011

Study Record Updates

Last Update Posted (ESTIMATE)

September 30, 2014

Last Update Submitted That Met QC Criteria

September 29, 2014

Last Verified

September 1, 2014

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • 004

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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