Event Related Potentials in Borderline Personality Disorder and Major Depression

May 14, 2021 updated by: Amruther G Ramamurthy, State University of New York - Upstate Medical University

This study examines whether depression in people with borderline personality disorder is different than depression in people without borderline personality disorder.

Unlike people who have depression alone (i.e. without borderline personality disorder), people with borderline personality disorder have depressions that often do not improve with medications. This makes treating depression much more challenging in someone with borderline personality disorder than without borderline personality disorder.

Borderline personality disorderis associated with difficulty in understanding and communicating feelings. Impaired emotion processing may reflect dysfunction of an area of the brain, the anterior cingulate.

Depression is associated with changes in anterior cingulate activity. The investigators believe that when borderline personality disorder is present with depression, brain activity changes in the anterior cingulate will not be the same as in depressed patients without borderline personality disorder.

An electroencephalogram records brain electrical activity. In this study, the investigators will measure electroencephalogram indices reflecting anterior cingulate activity.

HYPOTHESIS: In this study, the investigators predict that when borderline personality is present with depression, electroencephalogram indices of anterior cingulate activity will be different from when depression is present alone (without borderline personality). This could help to explain why people with borderline personality have depressions that are harder to treat than depressions in people without borderline personality.

The investigators also predict that electroencephalogram indices of the anterior cingulate will reflect emotional processing ability, as measured by validated questionnaires.

Study Overview

Status

Terminated

Conditions

Study Type

Observational

Enrollment (Actual)

30

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • New York
      • Syracuse, New York, United States, 13210
        • Upstate Medical University
      • Syracuse, New York, United States, 13078
        • Syracuse University - CNY Medical Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

Female

Sampling Method

Non-Probability Sample

Study Population

Females between age 18 to 45 recruited from staff (healthy controls) or from Upstate Medical University primary care outpatients, psychiatry outpatients, psychiatry inpatients

Description

Inclusion Criteria:

  • age between 18 and 45
  • female
  • noncontrols diagnosis: major depression &/or borderline personality disorder
  • Control participants should have neither major depression or borderline pers.
  • meet Structured Controlled Interview for DSM - II cut off scores
  • meet Beck Depression Inventory (BDI)cut off scores
  • meet Borderline Evaluation of Severity Over Time(BEST) cut off scores.

Exclusion Criteria:

  • based on having none of the below diagnoses from patient history, prior clinical records and based on MINI Plus International Neuropsychiatry Interview
  • schizophrenia
  • psychosis
  • Attention Deficit Hyperactivity Disorder
  • Obsessive Compulsive Disorder
  • bipolar disorder
  • mental retardation
  • dementia
  • CNS disease
  • Post-Traumatic Stress Disorder in non-borderline personality disorder groups
  • Recreational drug or alcohol use in the past week.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Other
  • Time Perspectives: Cross-Sectional

Cohorts and Interventions

Group / Cohort
Healthy Control
Healthy participants without borderline personality or depression
Major Depression, No Borderline Personality Disorder
With major depression and no borderline personality
Major Depression + Borderline Personality Disorder
With major depression and borderline personality disorder
No Major Depression, Borderline Personality Disorder
With no major depression, but with borderline personality disorder

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Error related negativity amplitude
Time Frame: on day 1 and then 4 weeks (average) later
electroencephalogram amplitude of the error related negativity
on day 1 and then 4 weeks (average) later
N2 amplitude
Time Frame: on day 1 and then 4 weeks (average) later
electroencephalogram amplitude of N2 wave
on day 1 and then 4 weeks (average) later

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

State University of New York - Upstate Medical University

Collaborators

Syracuse University

Investigators

  • Principal Investigator: Amruthur Ramamurthy, MD, State University of New York - Upstate Medical University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2011

Primary Completion (Actual)

March 1, 2015

Study Completion (Actual)

March 1, 2015

Study Registration Dates

First Submitted

October 26, 2010

First Submitted That Met QC Criteria

November 9, 2011

First Posted (Estimate)

November 10, 2011

Study Record Updates

Last Update Posted (Actual)

May 18, 2021

Last Update Submitted That Met QC Criteria

May 14, 2021

Last Verified

May 1, 2021

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 5910 (Other Grant/Funding Number: NCI)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

No

IPD Plan Description

There is no useful data

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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