- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01533129
The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism
July 21, 2020 updated by: Alper Sonmez, Gulhane School of Medicine
Phase 4 Study That Evaluates the Effects of Two Different Testosterone Replacement Regiments on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Subjects With Hypogonadotrophic Hypogonadism.
The study searched for answers to two questions
- What is the effect of testosterone replacement therapy on endothelial dysfunction, inflammation and insulin resistance?
- Regarding the above parameters, is there any difference between daily transdermal testosterone implementation and intramuscular injection performed in three weeks.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
106
Phase
- Phase 4
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Non US
-
Ankara, Non US, Turkey, 06018
- Gulhane School of Medicine Department of Endocrinology and Metabolism
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 26 years (ADULT)
Accepts Healthy Volunteers
No
Genders Eligible for Study
Male
Description
Inclusion Criteria:
- Men
- Treatment naive
- Hypogonadotrophic hypogonadism
Exclusion Criteria:
- Previous history of androgen replacement
- Chronic metabolic disorders
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NON_RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
ACTIVE_COMPARATOR: Daily testosterone transdermal gel
|
50mg testosterone gel implementation on every night
Other Names:
|
ACTIVE_COMPARATOR: Injectable Testosterone esters
Testosteron 250mg injection per 3-4 weeks for 6 months
|
The testosterone 250mg ester IM injections performed in three weeks.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
The alterations in the measures for endothelial functions
Time Frame: 6 months
|
The alterations in Endothelial functions are determined by measuring plazma ADMA levels, as a surrogate.
ADMA measurement is pereformed by ELISA kit (Immundiagnotik, Bensheim, Germany)(Catalog Number 7828) with a minimal detection limit of 0.05µmol/L.
|
6 months
|
The alterations in the measures of insulin resistance
Time Frame: 6 months
|
The alterations in insulin sensitivity are estimated by using the HOMA index by the formula, HOMA-IR = (insulin x glucose)/405.
|
6 months
|
The alterations in the measures of inflammation
Time Frame: 6 months
|
The alterations in the measures of inflammation are determined by measuring Human Pentraxin-3 levels.
ELISA kiti /R&D Systems, Inc. Minneapolis, MN, ABD) (Catalog number DPTX30) with a minimal detection limit of 0.025ng/ml, intraassay CV of 3.8-4.4%,
and interassay CV of 4.1-6.1% was used.
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
August 1, 2008
Primary Completion (ACTUAL)
April 1, 2011
Study Registration Dates
First Submitted
December 13, 2011
First Submitted That Met QC Criteria
February 14, 2012
First Posted (ESTIMATE)
February 15, 2012
Study Record Updates
Last Update Posted (ACTUAL)
July 22, 2020
Last Update Submitted That Met QC Criteria
July 21, 2020
Last Verified
July 1, 2020
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- GSM-022011
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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