- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01608516
Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque
Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET/CT, 18F-FDG PET/CT, MRI AND US
The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET/CT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET/CT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology.
Hypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.
Study Overview
Status
Intervention / Treatment
Detailed Description
Patients with indication for endarterectomy will be presented the present protocol. If inclusion criteria are fulfilled, patients will have a 18F-FDG PET/CT + carotid US performed 6 to 2 days before endarterectomy and 68Ga-NODAGA-RGD PET/CT + MRI performed the day before endarterectomy. Histopathological sample will be analyzed to measure plaque inflammation.
All imaging results and histopathology results will be pooled and compared.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
- Phase 1
Contacts and Locations
Study Contact
- Name: John O. Prior, PhD, MD
- Phone Number: +41 21 314 43 48
- Email: john.prior@chuv.ch
Study Contact Backup
- Name: Emmanuel Deshayes, MD
- Phone Number: +41 21 314 02 20
- Email: emmanuel.deshayes@chuv.ch
Study Locations
-
-
Vaud
-
Lausanne, Vaud, Switzerland, 1011
- Recruiting
- Centre Hospitalier Universitaire Vaudois
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- age <= 85 years
- Karnofsky >= 80%
- patient with indication ofr carotid endarterectomy
- signed consent form
Exclusion Criteria:
- indication for surgery other than endarterectomy <14 days
- contraindication to surgery
- contraindication to MRI
- contraindication to gadolinium injection (stage 4/5 kidney insufficiency, GFR<30ml/min/1.73m2)
- pregnancy, breastfeeding
- lack of discernment
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: 68Ga-NODAGA-RGD radiotracer
All patients will undergo a 68Ga-NODAGA-RGD PET/CT, a 18F-FDG PET/CT, a MRI and a US.
|
200 MBq 68 Ga-NODAGA-RGD will be administered i.v. and images centred on the carotid area acquired
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Comparison of each method of imaging for the detection of inflammatory atheromatous plaques
Time Frame: Within1 month of endarterectomy
|
The potential of each of the methods of imaging for the detection of inflammatory atheromatous plaques will be compared.
For that purpose, the capacity of every criterion of primary assessment to determine the presence of an unstable plaque will be studied compared with the histopathological sample.
|
Within1 month of endarterectomy
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Comparison of AUC of the imaging methods
Time Frame: Within1 month of endarterectomy
|
A comparison of the AUC will be realized to determine the superiority of a method compared with the other one, by a non parametric test comparing AUC , ROC curves respectively.
|
Within1 month of endarterectomy
|
Analysis of histopathological sample of endarterectomy
Time Frame: Within1 month of endarterectomy
|
The histopathological analysis will be the degree of local inflammation estimated by the macrophagic infiltration as well as the degree of neovascularization.
|
Within1 month of endarterectomy
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: John O. Prior, PhD, MD, Lausanne University Hospitals
Publications and helpful links
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 80/10
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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