The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life

Important health benefits of meditation may be conferred as much by what people actually do and say in their daily lives as by how they self-perceive the effect of training on their behavior and emotions. To test this hypothesis, and to explore whether specific elements of meditation (e.g. compassion vs. mindfulness) have different effects on real-world social behavior, the current project proposes to use the Electronically Activated Recorder (EAR) in a randomized, longitudinal design to objectively measure whether meditation does indeed make people behave in happier, kinder and more prosocial ways in their daily lives. This design will permit an exploratory analysis of how such behavioral transformations might relate to subjective reports of meditative effects. To accomplish these objectives, 108 medically healthy adults will be randomized to 8 weeks training in compassion meditation (n=36), Mindfulness Attention Training (MAT) (n = 36) or to an active control condition consisting of a health education discussion group (n=36). Prior to randomization and again upon completion of these interventions, all subjects will participate in an EAR protocol to evaluate the effect of meditation training on their real-world prosocial and affiliative behavior. Based on prior research and direct pilot data from 25 participants, prosocial and affiliative behavior will be assessed as the amount of (1) shown empathy and affection, (2) laughing vs. sighing, (3) arguing and complaining, (4) time spent interacting with others vs. alone, (5) meaningful conversations, (6) socially inclusive (i.e. use of "we"/us") vs. self-focused (i.e. use of "I"/me") first person language. Following the first EAR assessment, subjects will commence 8 weeks of compassion meditation training, MAT, or attendance in the health discussion group. Following these interventions subjects will participate in EAR monitoring identical to the initial assessment. To assess whether changes in daily behavior are sustained over a longer period, all subjects will undergo a final EAR assessment 6 months following completion of the study interventions. Self-report measures of social integration and support and behavioral/lifestyle variables that might be associated with EAR outcomes will be evaluated prior to each EAR assessment and treated as covariates.

Study Overview

• Status: Completed
• Conditions: Immune System Processes; Inflammatory Activation and Modulation; ANS Function
• Intervention / Treatment: Behavioral: Cognitive-Based Compassion Training; Behavioral: Adult Health Education Curriculum; Behavioral: Mindful Attention Training

• Study Type: Interventional
• Enrollment (Actual): 32
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Arizona
    • Tucson, Arizona, United States, 85724
      • University of Arizona

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 25 years to 55 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Males and females between the ages of 25 - 55 at study entry
• Ambulatory and in good medical health (see exclusion criteria below for specifics)
• Ability to read/understand English

Exclusion Criteria: Potential subjects will be excluded for any serious ongoing medical or psychiatric condition that might influence results or increase risk of stated participation, including but not limited to:

• Malignancy
• Auto-immune disorder
• Neurologic disorder
• Endocrinopathy; chronic infection (i.e. human immunodeficiency virus, hepatitis B or C)
• Any renal, hepatic or hematological abnormality (other than history of mild anemia)
• Current major depression or major depression requiring hospitalization or resulting in suicide attempt in past year
• Current active suicidal ideation as assessed by the Structured Clinical Interview for DSM-IV (SCID): current DSM-IV substance abuse
• Schizophrenia or bipolar disorder type 1
• BMI ≥ 30
• Any other current/past condition that might increase the risk of participation.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Compassion Meditation Group; Eight-week training in compassion meditation, using a protocol developed by Geshe Lobsang Negi, Ph.D. of Emory University	Behavioral: Cognitive-Based Compassion Training; Eight-week training in compassion meditation, using a protocol developed by Geshe Lobsang Negi, Ph.D. of Emory University
Active Comparator: Health Education and Wellness Group; Eight week training in health and wellness, using a curriculum developed specifically for this study.	Behavioral: Adult Health Education Curriculum; Eight week training in health and wellness, using a curriculum developed specifically for this study.
Experimental: Mindful Attention Training; Eight week training in mindful attention, using a protocol developed by B. Alan Wallace, Ph.D.	Behavioral: Mindful Attention Training; Eight week training in mindful attention, using a protocol developed by B. Alan Wallace, Ph.D.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Objectively-assessed, real-world, prosocial and affiliative behavior	Subjects will participate in 8 weeks of compassion meditation training, MAT, or attendance in the health discussion group. Electronically Activated Recorder (EAR) protocol will be used to evaluate the effect of meditation training on their real-world prosocial and affiliative behavior.	8 months

Collaborators and Investigators

• Sponsor: University of Arizona
• Investigators: Principal Investigator: Charles Raison, MD, University of Arizona

Study record dates

Study Major Dates

• Study Start: November 1, 2012
• Primary Completion (Actual): July 1, 2014
• Study Completion (Actual): July 1, 2014

Study Registration Dates

• First Submitted: July 16, 2012
• First Submitted That Met QC Criteria: July 17, 2012
• First Posted (Estimate): July 18, 2012

Study Record Updates

• Last Update Posted (Estimate): December 8, 2014
• Last Update Submitted That Met QC Criteria: December 5, 2014
• Last Verified: December 1, 2014

More Information

Terms related to this study

• Keywords: meditation; inflammation; immune system; compassion
• Other Study ID Numbers: 12-0123-02