Calorie Anticipation and Food Intake

Differences in Physiological Responses of Satiety and Reward After (in)Consistent Calorie Cues.

The regulation of our food intake is on the short-term guided by appetite and satiety signals generated by the sight and consumption of food. Food intake is not only regulated by appetite and satiety signals - external cues also play an important role.

It has been observed that food intake and the pleasure derived from consumption is affected by manipulation of the external cues.

The investigators will assess the contribution of food anticipation (calorie information) and actual consumption of a test food (calorie intake) on in satiety responses (such as ghrelin responses, appetite and subsequent food intake). The investigators expect the information on the amount of calories, rather than the actual amount of calories in the food, to predict the ghrelin responses and the subsequent intake of a second meal.

Study Overview

• Status: Completed
• Conditions: Obesity; Eating Behaviour
• Intervention / Treatment: Behavioral: low calorie yogurt; Behavioral: high calorie yogurt

Detailed Description

In a randomized cross-over design with 4 conditions, all participants will consume twice the low-caloric food (once with the low-calorie information and once with the high-calorie information) and twice the high-caloric food (again, once with the low-calorie information and once with the high-calorie information) in a randomized order.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Sweden
  • Uppsala, Sweden, 75319
    • Uppsala University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• female
• healthy
• being used to eat breakfast regularly (≥ 5 times a week).

Exclusion Criteria:

• hypersensitivity for the ingredients of the foods under study;
• lack of appetite; following an energy-restricted diet or change in body weight > 5 kg; or
• being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Calorie information; Low calorie yogurt High calorie yogurt with low calorie information sheet	Behavioral: low calorie yogurt; all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information); Behavioral: high calorie yogurt; all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)
Experimental: Calorie information (high); Low calorie yogurt High calorie yogurt High calorie information sheet	Behavioral: low calorie yogurt; all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information); Behavioral: high calorie yogurt; all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Food intake	60 min (Ad libitum test meal after 1 hr)

Secondary Outcome Measures

Outcome Measure	Time Frame
Serum concentrations total ghrelin	60 min (4 samples - every 20 min)

Other Outcome Measures

Outcome Measure	Time Frame
appetite ratings	80 min (5 samples - every 20 min)
Serum cortisol concentrations	60 min (4 samples - every 20 min)

Collaborators and Investigators

• Sponsor: Uppsala University
• Investigators: Principal Investigator: Pleunie Hogenkamp, PhD, Uppsala University

Publications and helpful links

General Publications

• Hogenkamp PS, Cedernaes J, Chapman CD, Vogel H, Hjorth OC, Zarei S, Lundberg LS, Brooks SJ, Dickson SL, Benedict C, Schioth HB. Calorie anticipation alters food intake after low-caloric not high-caloric preloads. Obesity (Silver Spring). 2013 Aug;21(8):1548-53. doi: 10.1002/oby.20293. Epub 2013 Apr 13.

Study record dates

Study Major Dates

• Study Start: May 1, 2012
• Primary Completion (Actual): July 1, 2012
• Study Completion (Actual): August 1, 2012

Study Registration Dates

• First Submitted: August 28, 2012
• First Submitted That Met QC Criteria: September 3, 2012
• First Posted (Estimate): September 7, 2012

Study Record Updates

• Last Update Posted (Estimate): September 7, 2012
• Last Update Submitted That Met QC Criteria: September 3, 2012
• Last Verified: August 1, 2012

More Information

Terms related to this study

• Keywords: food intake; Satiety,; satiation,; anticipation,
• Other Study ID Numbers: PH2012