Calorie Anticipation and Food Intake

September 3, 2012 updated by: Uppsala University

Differences in Physiological Responses of Satiety and Reward After (in)Consistent Calorie Cues.

The regulation of our food intake is on the short-term guided by appetite and satiety signals generated by the sight and consumption of food. Food intake is not only regulated by appetite and satiety signals - external cues also play an important role.

It has been observed that food intake and the pleasure derived from consumption is affected by manipulation of the external cues.

The investigators will assess the contribution of food anticipation (calorie information) and actual consumption of a test food (calorie intake) on in satiety responses (such as ghrelin responses, appetite and subsequent food intake). The investigators expect the information on the amount of calories, rather than the actual amount of calories in the food, to predict the ghrelin responses and the subsequent intake of a second meal.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

In a randomized cross-over design with 4 conditions, all participants will consume twice the low-caloric food (once with the low-calorie information and once with the high-calorie information) and twice the high-caloric food (again, once with the low-calorie information and once with the high-calorie information) in a randomized order.

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Sweden
      • Uppsala, Sweden, 75319
        • Uppsala University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Female

Description

Inclusion Criteria:

  • female
  • healthy
  • being used to eat breakfast regularly (≥ 5 times a week).

Exclusion Criteria:

  • hypersensitivity for the ingredients of the foods under study;
  • lack of appetite; following an energy-restricted diet or change in body weight > 5 kg; or
  • being a vegan or vegetarian. Participants reported not using products that are artificially sweetened, nor sugar in coffee and/or tea.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Calorie information

Low calorie yogurt

High calorie yogurt

with low calorie information sheet
Behavioral: low calorie yogurt
all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information)
Behavioral: high calorie yogurt
all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)
Experimental: Calorie information (high)

Low calorie yogurt

High calorie yogurt

High calorie information sheet
Behavioral: low calorie yogurt
all participants consumed twice the low-caloric food (once with the low-calorie information and once with the high-calorie information)
Behavioral: high calorie yogurt
all participants consumed twice the high-caloric food (once with the low-calorie information and once with the high-calorie information)

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Food intake
Time Frame: 60 min (Ad libitum test meal after 1 hr)
60 min (Ad libitum test meal after 1 hr)

Secondary Outcome Measures

Outcome Measure
Time Frame
Serum concentrations total ghrelin
Time Frame: 60 min (4 samples - every 20 min)
60 min (4 samples - every 20 min)

Other Outcome Measures

Outcome Measure
Time Frame
appetite ratings
Time Frame: 80 min (5 samples - every 20 min)
80 min (5 samples - every 20 min)
Serum cortisol concentrations
Time Frame: 60 min (4 samples - every 20 min)
60 min (4 samples - every 20 min)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Uppsala University

Investigators

  • Principal Investigator: Pleunie Hogenkamp, PhD, Uppsala University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

May 1, 2012

Primary Completion (Actual)

July 1, 2012

Study Completion (Actual)

August 1, 2012

Study Registration Dates

First Submitted

August 28, 2012

First Submitted That Met QC Criteria

September 3, 2012

First Posted (Estimate)

September 7, 2012

Study Record Updates

Last Update Posted (Estimate)

September 7, 2012

Last Update Submitted That Met QC Criteria

September 3, 2012

Last Verified

August 1, 2012

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • PH2012

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Subscribe