- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01684839
Treatment of Painful Digital Neuroma Using A Pedicled Nerve Flap
Neuroma excision and digital nerve reconstruction remain the best option for the treatment of Painful Digital Neuroma (PDN). When the distal nerve end is preserved, conventional nonvascularized nerve grafting is the primary option to bridge the defect. The investigators hypothesize the pedicled nerve flap taken from the dorsal branch of the homolateral digital nerve is better than conventional methods for reconstruction of the digital nerve defect after painful neuroma resection.
This study reports treatment of painful digital neuroma using a pedicled nerve flap taken from the dorsal branch of homolateral digital nerve. From May 2007 to March 2010, the patients had previous nerve injuries with or without nerve repair. The mechanisms of injury include sharp cut, avulsion and crush. The defects were between the middle of the distal phalanx and the palmar digital crease.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Hebei
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Tangshan, Hebei, China, 063000
- The Second Hospital of Tangshan
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- a patient with PDN in a scarred wound bed or poor coverage
- a PDN located between the middle of the distal phalanx and the palmar digital crease
- a defect of the digital nerve after neuroma resection equal to or less than 3 cm in length
Exclusion Criteria:
- a PDN in healthy soft tissue
- a digital nerve defect longer than 3 cm
- injury to the course of the pedicle or the donor nerve
- a thumb neuroma
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: new surgical treatment
Treatment of Painful Digital Neuroma Using A Pedicled Nerve Flap taken from the homolateral dorsal branch of the digital nerve.
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This nerve flap is a vascularized nerve graft
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Static 2-point Discrimination Test
Time Frame: 20-26 months postoperatively
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The Static 2-point Discrimination Test determined the minimal distance at which a subject can sense the presence of two needles.
The modified American Society for Surgery of the Hand guidelines was used to stratify the 2PD measurements (excellent <6 mm; good 6-10 mm; fair 11-15 mm; poor >15 mm).
The test points were at the center of the radial or ulnar portion of the finger pulp (i.e., injury side).
Each area was tested 3 times with a discriminator (Ali Med, Dedham, MA).
Two out of 3 correct answers were considered proof of perception before proceeding to another lower value.
We stopped at 4mm as a limit of 2PD and consider this normal.
The measurements were performed at a single time point at the final follow up.
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20-26 months postoperatively
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cold Intolerance Severity Score (CISS) Questionnaire
Time Frame: 20-26 months postoperatively
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The maximum score was 100 and was grouped into 4 ranges (0-25; 26-50; 51-75; and 76-100), corresponding to mild, moderate, severe, and extreme severity, respectively.
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20-26 months postoperatively
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Tinel's Sign
Time Frame: 20-26 months postoperatively
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Tinel's sign was graded as the following: grade 1=none; grade 2=mild, slight tingle; grade 3=moderate, very uncomfortable; and grade 4=severe, patient unable to use hand because of any stimulation of the neuroma
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20-26 months postoperatively
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Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Gang Zhao, MD., The Second Hospital of Tangshan
Publications and helpful links
General Publications
- Herndon JH, Eaton RG, Littler JW. Management of painful neuromas in the hand. J Bone Joint Surg Am. 1976 Apr;58(3):369-73.
- Tupper JW, Booth DM. Treatment of painful neuromas of sensory nerves in the hand: a comparison of traditional and newer methods. J Hand Surg Am. 1976 Sep;1(2):144-51. doi: 10.1016/s0363-5023(76)80008-1.
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- HB-TS-120127
- TSCHEN411206 (Other Identifier: Ethics Committee of HeBei Province)
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
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