- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01789710
Contingency Management for Smoking Cessation in Homeless Smokers
The purpose of this study is to examine the effectiveness of an internet-based contingency management program for smoking cessation in persons who are homeless. Thirty homeless smokers will be enrolled in the study. Participants will receive payment based on their own low carbon monoxide readings, which indicate being quit from smoking. Participants will be prescribed nicotine replacement (patches and either gum or lozenge)and bupropion. All participants will receive a four sessions of smoking cessation counseling, and will be trained to perform carbon monoxide monitoring with a device provided by the study. They will also be provided with a mobile phone equipped with a video camera, and will use this equipment at home to monitor their carbon monoxide . Participants will record videos of themselves taking a carbon monoxide reading and displaying the results, and will upload the videos to a secured website that is only accessible by the research team members and the participant. Payment will be based on providing carbon monoxide readings that indicate abstinence.
The study is designed to address the following aims:
Specific Aim 1: To evaluate whether it is feasible to use internet-based contingency management for helping smokers who are homeless stop smoking.
Specific Aim 2: To evaluate how effective internet-based contingency managementis on decreasing smoking in smokers who are homeless.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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North Carolina
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Durham, North Carolina, United States, 27705
- VA Medical Center
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- must be a Veteran who is eligible for care within the VA system;
- must be currently homeless or have been homeless more than twice in the past year period;
- must have current smoking status of at least 10 cigarettes per day for at least 1 year (verified with breath carbon monoxidemeasurement);
- must be aged 18 to 70;
- must be English speaker
Exclusion Criteria:
- Pregnancy;
- Any substance use disorder in any of the following drug categories: opioids, cocaine, alcohol, sedatives, stimulants, hallucinogens, or drugs categorized as "other" per the Structured Clinical Interview for Diagnostic and Statistical Manual-IV.
- Urine drug screen results positive for cocaine, amphetamines, stimulants, opioids, or hallucinogens;
- Not stable on medications for the study period;
- Use of any other forms of nicotine such as cigars, pipes, or chewing tobacco;
- Participants may be excluded if they have a seizure disorder, uncontrolled diabetes or an eating disorder;
- Prior history of hepatitis or cirrhosis; current hepatitis or cirrhosis
- Score less than 80 on Kaufman Brief Intelligence Test
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: NON_RANDOMIZED
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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EXPERIMENTAL: Active Contingency Management
All participants are assigned to a single arm, active contingency management.
In this arm, participants are provided monetary rewards for remaining abstinent from smoking.
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All participants who are medically eligible to take Bupropion will receive this study medication one week prior to their smoking quit date.
Other Names:
All participants will receive two forms of nicotine replacement therapy - nicotine patches and a rescue method (either gum or lozenge).
Other Names:
All participants will be asked to provide home carbon monoxide monitoring with equipment that is loaned to them.
When participants provide readings that are low enough to suggest abstinence from smoking, they are provided monetary reinforcement (i.e., money).
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
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Breath carbon monoxide
Time Frame: Throughout study - one year
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Throughout study - one year
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Saliva cotinine
Time Frame: 2 months, 3 months, 6 months
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When the body processes nicotine, it produces cotinine.
Cotinine can be found in saliva.
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2 months, 3 months, 6 months
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Jean C. Beckham, Ph.D., Duke University Medical Center; VA Medical Center
Publications and helpful links
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Autonomic Agents
- Peripheral Nervous System Agents
- Cholinergic Agents
- Enzyme Inhibitors
- Psychotropic Drugs
- Neurotransmitter Uptake Inhibitors
- Membrane Transport Modulators
- Antidepressive Agents
- Dopamine Agents
- Cytochrome P-450 Enzyme Inhibitors
- Ganglionic Stimulants
- Nicotinic Agonists
- Cholinergic Agonists
- Antidepressive Agents, Second-Generation
- Cytochrome P-450 CYP2D6 Inhibitors
- Dopamine Uptake Inhibitors
- Nicotine
- Bupropion
Other Study ID Numbers
- Pro00040194
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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