The Effects of L-arabinose in a Meal in Healthy Men

The Effects of L-arabinose in a Meal on Glucose Metabolism in Healthy Men

The purpose of this study is to investigate the effect of a meal containing different doses of L-arabinose, on the intestinal sucrase activity after intake We measure this by measuring the glucose, insulin and c-peptide after meals. Other measurements are made (glucagon and GLP-1) to explain the correlations.

Study Overview

• Status: Completed
• Conditions: Glucose Metabolism
• Intervention / Treatment: Dietary supplement: L-arabinose - effect on glucose metabolism

• Study Type: Interventional
• Enrollment (Actual): 17
• Phase: Not Applicable

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy male
• normal weight (BMI 18,5-25 kg/m2)
• 18-30 years of age

Exclusion Criteria:

• Not healthy,including those with diabetes Mellitus, high bloodpressure, dyslipidemia or a infectious diseases (hepatitis or HIV), gastrointestinal disorders
• Central adipositas (defined as waist circumference > 94 cm for european men)
• Daily intake of vitamins and minerals, 3 months before the trail starts and during the trail.
• elevated alcoholcunsumption(> 21 units af alcohol pr. week)
• take medicine
• Elite athlete with intensive training
• given bloddonation within the last 3 months
• smoking

Study Plan

How is the study designed?

Design Details

• Primary Purpose: PREVENTION
• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: QUADRUPLE

Number of Arms

6

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: 0% arabinose meal sucrose/starch; A meal containing a bon with butter and marmalade, a cup cake, The and water	Dietary supplement: L-arabinose - effect on glucose metabolism; L-arabinose is mixed into the dough of the buns and cup cakes
OTHER: 5 % arabinose meal sucrose/starch; A meal containing a bon with butter and marmalade, a cup cake, The and water	Dietary supplement: L-arabinose - effect on glucose metabolism; L-arabinose is mixed into the dough of the buns and cup cakes
OTHER: 10 % arabinose meal sucrose/starch; A meal containing a bon with butter and marmalade, a cup cake, The and water	Dietary supplement: L-arabinose - effect on glucose metabolism; L-arabinose is mixed into the dough of the buns and cup cakes
OTHER: 0 % arabinose meal Starch; A meal containing two bons with butter and cheese, The and water	Dietary supplement: L-arabinose - effect on glucose metabolism; L-arabinose is mixed into the dough of the buns and cup cakes
OTHER: 5 % arabinose meal starch; A meal containing two bons with butter and cheese, The and water	Dietary supplement: L-arabinose - effect on glucose metabolism; L-arabinose is mixed into the dough of the buns and cup cakes
OTHER: 10 % arabinose meal starch; A meal containing two bons with butter and cheese, The and water	Dietary supplement: L-arabinose - effect on glucose metabolism; L-arabinose is mixed into the dough of the buns and cup cakes

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucose	Level of glucose over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min
Insulin	Level of insulin over time, the AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min
C-peptide	Level of c-peptide over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glucagon	Level of glucagon over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min
GLP-1	Level of GLP-1 over time, The AUC, the peak value and time to peak	-15, 0, 15, 30, 45, 60, 90, 120, 180 min

Collaborators and Investigators

• Sponsor: University of Copenhagen
• Investigators: Study Director: Jens Rikardt Andersen, MD, lector, Unit of Nutrition 5711, Rigshospitalet, Blegdamsvej 9, 2100 København Ø

Study record dates

Study Major Dates

• Study Start: December 1, 2010
• Primary Completion (ACTUAL): March 1, 2011
• Study Completion (ACTUAL): March 1, 2011

Study Registration Dates

• First Submitted: February 27, 2013
• First Submitted That Met QC Criteria: February 27, 2013
• First Posted (ESTIMATE): February 28, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): February 28, 2013
• Last Update Submitted That Met QC Criteria: February 27, 2013
• Last Verified: February 1, 2013

More Information

Terms related to this study

• Other Study ID Numbers: H-2-2010-095