Effects of Navigated Repetitive Transcranial Magnetic Stimulation According to Post-stroke Aphasia Types

June 26, 2017 updated by: Nam-Jong Paik, Seoul National University Bundang Hospital
Repetitive transcranial magnetic stimulation induced virtual lesions for aphasia.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

To evaluate the effect of navigated repetitive transcranial magnetic stimulation in subjects with aphasia after stroke.

Study Type

Interventional

Enrollment (Actual)

12

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Korea, Republic of
    • Bundang-gu
      • Seongnam-si, Bundang-gu, Korea, Republic of, 463-707
        • Seoul National University Bundang Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (ADULT, OLDER_ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • fluent in Korean
  • older than 18 years old

Exclusion Criteria:

  • younger than 18 years old
  • psychotic or psychiatric problems
  • pregnant
  • contraindications to MRI/fMRI
  • uncooperative
  • metalic implants, pacemaker or cochlear implants
  • cannot perform outcome measure-related task
  • known seizure history

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: TREATMENT
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: SINGLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
EXPERIMENTAL: Middle temporal gyrus
Repetitive magnetic stimulation to middle temporal gyrus
Device: Repetitive magnetic stimulation to middle temporal gyrus
Repetitive magnetic stimulation to middle temporal gyrus
Other Names:
  • MagPro X100 magnetic stimulator
SHAM_COMPARATOR: Control group
Repetitive magnetic stimulation (Sham)
Device: Repetitive magnetic stimulation (Sham)
Repetitive magnetic stimulation (Sham)
Other Names:
  • MagPro X100 magnetic stimulator
EXPERIMENTAL: Superior temporal gyrus
Repetitive magnetic stimulation to superior temporal gyrus
Device: Repetitive magnetic stimulation to superior temporal gyrus
Repetitive magnetic stimulation to superior temporal gyrus
Other Names:
  • MagPro X100 magnetic stimulator

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The Change of Reaction Time Between Before and After Stimulation in Each Session (MTG, STG, Sham)
Time Frame: change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3)

Reaction time for lexical and repetition test were measured before and after the TMS stimulation at each sessions (at session 1, session 2, session 3 over MTG/STG/Sham; MTG: middle temporal gyrus, STG: superior temporal gyrus).

Response times were measured via the response pad, and spoken responses were recorded via a SV-1 Voice Key apparatus.

The "reaction time post TMS - reaction time pre TMS" were used for analysis.* Arm/Group Title Arm/Group Description Maximum length (999) Repetitive magnetic stimulation (rTMS) were applied over STG
change between before and after the TMS stimulation for each sessions (at session 1, session 2, session 3)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Seoul National University Bundang Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

December 1, 2012

Primary Completion (ACTUAL)

May 1, 2013

Study Completion (ACTUAL)

May 1, 2013

Study Registration Dates

First Submitted

March 11, 2013

First Submitted That Met QC Criteria

June 10, 2013

First Posted (ESTIMATE)

June 13, 2013

Study Record Updates

Last Update Posted (ACTUAL)

July 31, 2017

Last Update Submitted That Met QC Criteria

June 26, 2017

Last Verified

June 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • E-1206-158-003

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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