Bone Loss in Patients With Anorexia Nervosa

May 11, 2026 updated by: University Hospital, Montpellier

Physiopathology of Bone Loss in Young Patient With Anorexia Nervosa

Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences.

160 patients (age < 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

320

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
      • Montpellier, France, 34295
        • CHU de Montpellier - Département d'Endocrinologie Diabète

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

14 years to 38 years (Child, Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Informed Consent
  • Health Insurance regimen or benefit from an health insurance regimen
  • Aged from 14 to 38 years old
  • Women
  • No pregnant

Specific inclusion criteria for patient:

Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)

Specific inclusion criteria for controls:

  • Normal menstrual cycles,
  • No lifetime history of eating disorders,
  • BMI between 18 and 25 kg/m²

Exclusion Criteria:

  • use of treatments may be modify bone mass (bisphosphonates,…)
  • Disease or treatment may be induce osteoporosis
  • In exclusion period in relation with another study
  • Law protected subject

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Patients with anorexia nervosa
This arm is the experimental arm composed of patients
Other: clinical parameters description
description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms
Other: para clinical parameters description
description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms
Other: hormonal parameters dosing
dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms
Other: bone modeling markers dosing
dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms
Active Comparator: controls subjects
This arm is composed of healthy volunteers
Other: clinical parameters description
description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms
Other: para clinical parameters description
description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms
Other: hormonal parameters dosing
dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms
Other: bone modeling markers dosing
dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Dual-X-ray absorptiometry (DEXA)
Time Frame: at Day 0 (time of the inclusion visit)
The primary outcome is to model the bone mass acquisition in young women with anorexia nervosa.
at Day 0 (time of the inclusion visit)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Biological parameters identification
Time Frame: At day 0 (time of the inclusion visit)
One of the secondary outcome is to identify biological factors associated with bone demineralisation.
At day 0 (time of the inclusion visit)
clinical parameters identification
Time Frame: At Day 0 (at time of the the inclusion visit)
One of the secondary outcome is to identify the clinical factors associated with bone demineralisation.
At Day 0 (at time of the the inclusion visit)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University Hospital, Montpellier

Investigators

  • Principal Investigator: Patrick PL LEFEBVRE, MD, University Hospital, Montpellier

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

September 1, 2011

Primary Completion (Actual)

April 1, 2017

Study Completion (Actual)

April 25, 2017

Study Registration Dates

First Submitted

July 17, 2013

First Submitted That Met QC Criteria

July 22, 2013

First Posted (Estimated)

July 25, 2013

Study Record Updates

Last Update Posted (Actual)

May 14, 2026

Last Update Submitted That Met QC Criteria

May 11, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 8751

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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