Wound-healing Improvement by Resurfacing Split-Thickness Skin Donor Sites With Thin Split-thickness Grafting

Split-thickness skin grafting remains fundamental treatment of patients with deep burns and other traumatic injuries. However, the split-thickness skin graft (STSG) donor site dressing has been controversial until now. Our study here aimed to assess patient comfort and wound-healing efficacy with the application of thin split-thickness grafting on STSG donor sites.

Study Overview

• Status: Completed
• Conditions: Disorder of Skin Donor Site; Skin Graft Disorder; Wound Healing Disturbance of
• Intervention / Treatment: Procedure: regrafted with thin split-thickness skin graft; Procedure: covered with the occlusive hydrocellular dressing; Procedure: covered with paraffin gauze

Detailed Description

Background：Split-thickness skin grafting remains fundamental treatment of patients with deep burns and other traumatic injuries. However, the split-thickness skin graft (STSG) donor site dressing has been controversial until now. Our study here aimed to assess patient comfort and wound-healing efficacy with the application of thin split-thickness grafting on STSG donor sites.

Methods: 192 consecutive patients undergoing split-thickness skin grafting were included in the study and the participants were randomly divided into three groups: Group A was regrafted with thin STSG, while, Group B and Group C were covered with the occlusive hydrocellular dressing and paraffin gauze, respectively. The three groups were compared regarding to the time of epithelialization, pain sensed by the patients and the scar formation.

• Study Type: Observational
• Enrollment (Actual): 192

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 years to 56 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

The study cohort included 192 participants, who were randomly selected from patients who continuously received an STSG from January 2002 to December 2010 in Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University.

Description

Inclusion Criteria:

• patients who continuously received an STSG from January 2002 to December 2010 in Department of Burn and Plastic Surgery, Tangdu Hospital, Fourth Military Medical University

Exclusion Criteria:

• The patients who were significant psychiatric, hypersensitive to silver, and not be followed up were excluded

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
the treatment group A; The people in treatment group were regrafted with thin split-thickness skin graft	Procedure: regrafted with thin split-thickness skin graft; Group A (the treatment group) were regrafted with thin split-thickness skin graft
the control group B; The group B covered with the occlusive hydrocellular dressing (Allevyn Adhesive, Smith & Nephew)	Procedure: covered with the occlusive hydrocellular dressing; group B covered with the occlusive hydrocellular dressing (Allevyn Adhesive, Smith & Nephew)
the control group C; Group C were covered with paraffin gauze	Procedure: covered with paraffin gauze; Group C covered with paraffin gauze

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The time of epithelialization	The time of epithelialization was observed every 3 days	up to 4 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Pain sensed by the patients	Pain sensed by the patients was assessed by Wong-Baker FACES Pain Rating Scale on day 2 and 5 after surgery	up to 6 months

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Scar formation of skin donor site	Scar formation of skin donor sites was evaluated by Vancouver scar scale in terms of colour, vascular distribution, thickness and scratchability 6-12 months after surgery	1 year

Collaborators and Investigators

• Sponsor: Tang-Du Hospital
• Investigators: Study Director: Yongqian Bian, doctor, specify unaffiliated

Study record dates

Study Major Dates

• Study Start: January 1, 2002
• Primary Completion (ACTUAL): December 1, 2010
• Study Completion (ACTUAL): March 1, 2013

Study Registration Dates

• First Submitted: September 12, 2013
• First Submitted That Met QC Criteria: October 27, 2013
• First Posted (ESTIMATE): November 1, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): November 1, 2013
• Last Update Submitted That Met QC Criteria: October 27, 2013
• Last Verified: October 1, 2013

More Information

Terms related to this study

• Keywords: wound healing; the split-thickness skin graft （STSG） donor site; regraft
• Additional Relevant MeSH Terms: Pathologic Processes; Disease; Wounds and Injuries; Skin Diseases
• Other Study ID Numbers: TDLL-2030130