- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01993433
A Safety and Efficacy Study of DRM02 in Subjects With Plaque Psoriasis
A Randomized, Double-blind, Vehicle Controlled Study of the Safety and Efficacy of Topical DRM02 in Subjects With Plaque Psoriasis
Study Overview
Detailed Description
This is a double-blind, randomized, within-subject control, study enrolling 20 subjects with plaque psoriasis and designed to assess the safety, tolerability, and preliminary efficacy of DRM02.
Safety will be assessed during the study, through adverse events, local skin responses, urinalysis, serum chemistry and hematology laboratory testing, physical examination and vital signs.
Preliminary efficacy will be assessed through the Physician's Lesion Assessment (PLA) and the Severity of Psoriasis Area Severity Index (PASI) from only the two plaques identified at the baseline visit.
Study Type
Enrollment (Actual)
Phase
- Phase 2
Contacts and Locations
Study Locations
-
-
Quebec
-
Drummondville, Quebec, Canada, J2B5L4
- Clinique Médicale Dr Isabelle Delorme
-
Montreal, Quebec, Canada, H2K 4L5
- Innovaderm Research, Inc
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Male or female 18 to 70 years of age.
- Plaque-type psoriasis with two lesions of similar size and have an identical score of at least 6 but no more than 8 on the sum of the individual components of the Severity of Psoriasis Area Severity Index (PASI) at the Target Lesion scale.
- Male or non-pregnant, non-lactating females.
- Signed informed consent.
Exclusion Criteria:
- Subjects who have extensive, and/or 'inverse', and/or exfoliative psoriasis.
- Subjects who have taken any systemic treatment for psoriasis within the 4 weeks prior to baseline.
- Prior or concomitant use of topical treatments for psoriasis to within 10 cm of the target lesion within the 4 weeks prior to baseline.
- Use of Enbrel within the 4 weeks prior to baseline.
- Psoralen & ultraviolet A therapy (PUVA) or the use of ultraviolet B (UVB) therapy and/or excessive or prolonged exposure to ultraviolet light within the 4 weeks prior to baseline.
- Use of Humira or Remicade within the 3 months prior to baseline.
- Use of Stelara within the 6 months prior to baseline.
- Subjects who have taken oral retinoids for psoriasis within the 6 months prior to baseline.
- Subjects who have poor skin condition within 5 cm of the target lesion.
- Subjects who are current drug or alcohol abusers; have a history of immunodeficiency disease or are a poor medical risk because of other systemic diseases or active uncontrolled infections.
- Subjects with an unstable medical condition or a medical condition not adequately controlled with standard medical therapy.
- Subjects who are actively participating in an experimental therapy study or who have received experimental therapy within 30 days
- Subjects who have a clinically significant laboratory value at screening.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: TRIPLE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: DRM02
DRM02 Topical Gel, 0.25%
|
|
PLACEBO_COMPARATOR: Vehicle
DRM02 Topical Gel, Vehicle
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Change in Physician's Lesion Assessment
Time Frame: Week 6
|
Week 6
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Physician's Lesion Assessment
Time Frame: From baseline to weeks 0, 1, 2, 3, 4 and 6
|
From baseline to weeks 0, 1, 2, 3, 4 and 6
|
PLA dichotomized into "success" and "failure"
Time Frame: Week 6
|
Week 6
|
Other Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Severity of Target Lesion PASI scores
Time Frame: Week 6
|
Week 6
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- DRM02-PSO02
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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