Jugular Venous Flow Healthy Volunteers

May 21, 2020 updated by: Lashmi Venkatraghavan, University Health Network, Toronto

Effect of Different Surgical Positions on the Cerebral Venous Drainage: an Ultrasound Study on Healthy Volunteers

Our hypothesis is that there will be a decrease in internal jugular venous flow in the park bench position when compared to the supine position. There will also be a change in blood flow in the between right and left internal jugular veins in park bench position, particularly there will be a greater reduction of flow on the dependent side. However, the internal jugular venous flow will be the same in both the prone and supine position.

Study Overview

Status

Completed

Intervention / Treatment

Detailed Description

The different positions used in neurosurgery (park bench, prone) for better accessibility to the operating field can impact on the cerebral venous drainage due to the effects of internal jugular venous outflow of blood and may increase intracranial pressure. The kinking of the internal jugular vein due to excessive neck flexion and rotation in park bench or flexion in the prone position may lead to kinking or twisting of the vein. This has been hypothesized as the major cause of disturbed venous drainage during surgery and in postoperative patients may lead to neck swelling, brachial plexus injury, macroglossia (swollen tongue), delayed airway obstruction and increases in intracranial pressure.

Optimal brain perfusion is best in the neutral position of the head, but surgery cannot always be performed with this. Thus, we look to measure the internal jugular venous flow at different positions as there have been little studies looking at this important contributing factor.

Study Type

Observational

Enrollment (Actual)

27

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

    • Ontario
      • Toronto, Ontario, Canada, M5T 2S8
        • University Health Network, Toronto Western Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Healthy Volunteers

Description

Inclusion Criteria:

  • Adult healthy volunteers who are above the age of 18
  • American Society of Anesthesiologists classification (ASA) 1
  • Body mass index (BMI) less than and equal to 35

Exclusion Criteria:

  • ASA 2 and above
  • BMI above 35
  • Lack of informed consent
  • Language barrier
  • Medical students and anaesthesia residents going through the department as part of their rotation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
volunteers in different positions

The following will be compared in the same volunteer:

  • Bilateral internal jugular venous flow in supine and prone position
  • Bilateral internal jugular venous flow in supine and park bench position
  • Bilateral internal jugular venous flow in prone and park bench
Jugular venous blood flow in healthy volunteers in 3 different positions- supine, prone and park bench

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Internal Jugular Venous (IJV) Cross Sectional Area
Time Frame: 1 day
Comparisons of both jugular vein (IJV) of twenty-seven volunteers in supine and prone positions.
1 day
Right and Left IJV Cross Sectional Area
Time Frame: 1 day
Twenty-seven volunteers were included in this study. Comparisons of cross sectional area measurements in both IJVs between supine and right park bench
1 day
Internal Jugular Venous (IJV) Doppler Velocity
Time Frame: 1 day
27 volunteers enrolled to measure the Internal Jugular Venous (IJV) in supine and prone positions
1 day
Bilateral Internal Jugular Vein (IJV) Flow
Time Frame: 1 day
Comparisons of bilateral internal jugular vein (IJV) flow between supine and prone position. Data presented as mean (SD) .
1 day
Bilateral Internal Jugular Vein (IJV) Doppler Velocity
Time Frame: 1 day
Comparisons of bilateral internal jugular vein (IJV) Doppler velocity between supine and right park bench position.
1 day
R IJV and L IJV Flow
Time Frame: 1 day
Bilateral internal jugular vein (IJV) flow between supine and right park bench position.
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Investigators

  • Principal Investigator: Lashmi Venkatraghavan, University Health Network, Toronto Western Hospital
  • Principal Investigator: Vincent Chan, University Health Network, Toronto Western Hospital
  • Principal Investigator: Pirjo Manninen, University Health Network, Toronto Western Hospital
  • Principal Investigator: Audrey MY Tan, University Health Network, Toronto Western Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2013

Primary Completion (Actual)

February 1, 2014

Study Completion (Actual)

February 1, 2014

Study Registration Dates

First Submitted

November 29, 2013

First Submitted That Met QC Criteria

December 4, 2013

First Posted (Estimate)

December 5, 2013

Study Record Updates

Last Update Posted (Actual)

June 4, 2020

Last Update Submitted That Met QC Criteria

May 21, 2020

Last Verified

May 1, 2020

More Information

Terms related to this study

Other Study ID Numbers

  • 13-6244-BE

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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