- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02002494
Jugular Venous Flow Healthy Volunteers
Effect of Different Surgical Positions on the Cerebral Venous Drainage: an Ultrasound Study on Healthy Volunteers
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The different positions used in neurosurgery (park bench, prone) for better accessibility to the operating field can impact on the cerebral venous drainage due to the effects of internal jugular venous outflow of blood and may increase intracranial pressure. The kinking of the internal jugular vein due to excessive neck flexion and rotation in park bench or flexion in the prone position may lead to kinking or twisting of the vein. This has been hypothesized as the major cause of disturbed venous drainage during surgery and in postoperative patients may lead to neck swelling, brachial plexus injury, macroglossia (swollen tongue), delayed airway obstruction and increases in intracranial pressure.
Optimal brain perfusion is best in the neutral position of the head, but surgery cannot always be performed with this. Thus, we look to measure the internal jugular venous flow at different positions as there have been little studies looking at this important contributing factor.
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Ontario
-
Toronto, Ontario, Canada, M5T 2S8
- University Health Network, Toronto Western Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- Adult healthy volunteers who are above the age of 18
- American Society of Anesthesiologists classification (ASA) 1
- Body mass index (BMI) less than and equal to 35
Exclusion Criteria:
- ASA 2 and above
- BMI above 35
- Lack of informed consent
- Language barrier
- Medical students and anaesthesia residents going through the department as part of their rotation
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
volunteers in different positions
The following will be compared in the same volunteer:
|
Jugular venous blood flow in healthy volunteers in 3 different positions- supine, prone and park bench
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Internal Jugular Venous (IJV) Cross Sectional Area
Time Frame: 1 day
|
Comparisons of both jugular vein (IJV) of twenty-seven volunteers in supine and prone positions.
|
1 day
|
Right and Left IJV Cross Sectional Area
Time Frame: 1 day
|
Twenty-seven volunteers were included in this study.
Comparisons of cross sectional area measurements in both IJVs between supine and right park bench
|
1 day
|
Internal Jugular Venous (IJV) Doppler Velocity
Time Frame: 1 day
|
27 volunteers enrolled to measure the Internal Jugular Venous (IJV) in supine and prone positions
|
1 day
|
Bilateral Internal Jugular Vein (IJV) Flow
Time Frame: 1 day
|
Comparisons of bilateral internal jugular vein (IJV) flow between supine and prone position.
Data presented as mean (SD) .
|
1 day
|
Bilateral Internal Jugular Vein (IJV) Doppler Velocity
Time Frame: 1 day
|
Comparisons of bilateral internal jugular vein (IJV) Doppler velocity between supine and right park bench position.
|
1 day
|
R IJV and L IJV Flow
Time Frame: 1 day
|
Bilateral internal jugular vein (IJV) flow between supine and right park bench position.
|
1 day
|
Collaborators and Investigators
Investigators
- Principal Investigator: Lashmi Venkatraghavan, University Health Network, Toronto Western Hospital
- Principal Investigator: Vincent Chan, University Health Network, Toronto Western Hospital
- Principal Investigator: Pirjo Manninen, University Health Network, Toronto Western Hospital
- Principal Investigator: Audrey MY Tan, University Health Network, Toronto Western Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 13-6244-BE
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Jugular Venous Blood Flow
-
University Health Network, TorontoWithdrawn
-
Lashmi VenkatraghavanUniversity Health Network, TorontoCompleted
-
Selcuk UniversityNot yet recruitingInternal Jugular Vein (IJV) Blood Flow in Gynecological Laparoscopic Surgery
-
Kasr El Aini HospitalRecruitingAnesthesia | Ultrasound | Central Venous Catheter | Pediatric | Internal Jugular VeinEgypt
-
Mikel BatlloriInstituto de Salud Carlos IIICompletedUltrasound-guided Internal Jugular Cannulation | Central Venous Access ComplicationsSpain
-
Bozyaka Training and Research HospitalCompletedCentral Venous Catheter | Radiography | Internal Jugular Vein | Subclavian Vein InjuryTurkey
-
Mahidol UniversityCompletedCentral Venous Pressure | Internal Jugular Size Measured by UltrasoundThailand
-
Capital Medical UniversityRecruitingImage | Abnormal Cerebral Venous Sinus Morphology | Internal Jugular Vein StenosisChina
-
Synergy Health Concepts, Inc.UnknownVenous Irregularities, Flow and Perfusion in MS and Non-MS ParticipantsUnited States
-
University of ChicagoTerminatedJugular Venous Pulse Measurement in Critically Ill PatientsUnited States
Clinical Trials on Different positions
-
Ahram Canadian UniversityRecruitingCarpal Tunnel SyndromeEgypt
-
Tel-Aviv Sourasky Medical CenterUnknown
-
Istanbul University - Cerrahpasa (IUC)Completed
-
Hospital Privado de Comunidad de Mar del PlataCompleted
-
Amazon UniversityCompletedHemodynamics | Therapeutic PositionBrazil
-
Unity Health TorontoActive, not recruitingTrauma Chest | Mechanical VentilationCanada
-
Gaziosmanpasa Research and Education HospitalCompleted
-
Istanbul University - Cerrahpasa (IUC)RecruitingGastric Residual Volume | Abdominal Oxygenation | Fractional Oxygen Extraction | Positioning (Prone, Right Lateral and Semi-Elevated Supine Position)Turkey
-
Canadian Memorial Chiropractic CollegeCanadian Medical Protective Association; NCMICUnknownCerebrovascular Accident | Cerebrovascular Stroke | Vertebral Artery DissectionCanada
-
Canadian Memorial Chiropractic CollegeNational Chiropractic Mutual Insurance Company (NCMIC)CompletedStroke | Cerebrovascular Accident | Vertebral Artery DissectionCanada