Changes in Food Preference and Food Cue Responsivity After Bariatric Surgery (Verrukkelijk)

It has been suggested that obese people are more sensitive to sensory and rewarding effects of food, aspects that mediate food preferences and intake. Individuals that underwent Roux-en-Y gastric bypass surgery frequently report changes in food preference. They indicate a decreased preference for highly rewarding energy dense foods. Changes in food preference might be related to alterations in central (brain) mechanisms, related to reward sensing. The smell and sight of food can be considered as anticipatory cues for the rewarding effects of food intake. The aim of this study is to determine the effect of gastric bypass surgery on (alterations in) food preferences. Secondly, this study aims at assessing the effect of gastric bypass surgery on the brain reward response when exposed to sight and smell of food stimuli with different sugar and fat contents.

Study Overview

• Status: Unknown
• Conditions: Roux-en-Y Gastric Bypass
• Intervention / Treatment: Procedure: Roux-en-Y Gastric Bypass

• Study Type: Observational
• Enrollment (Anticipated): 100

Contacts and Locations

Study Locations

• Netherlands
  • Gelderland
    • Arnhem, Gelderland, Netherlands, 6800 TA
      • Rijnstate Hospital
    • Ede, Gelderland, Netherlands, 6716 RP
      • Gelderse Vallei Hospital
    • Wageningen, Gelderland, Netherlands, 6700 EV
      • Wageningen University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 51 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Morbidly obese individuals (age 18-55 years) scheduled for Roux-en-Y gastric bypass surgery at Rijnstate hospital, Arnhem

Description

Inclusion Criteria:

• Scheduled for Roux-en-Y Gastric Bypass Surgery at Rijnstate hospital

Exclusion Criteria:

• Lack of appetite
• Having difficulties swallowing/eating
• Being a vegetarian
• Allergic to food product used as stimuli in the study

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Prospective

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
RYGB; Food preference assessment in 100 patients at different timepoints, in a subset of 30 participants, also brain reward response to food cues will be assessed.	Procedure: Roux-en-Y Gastric Bypass

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Development of food preferences after Roux-en-Y gastric bypass surgery	Food preferences will be assessed 2 weeks before Roux-en-Y Gastric Bypass surgery and 2 months, 1 year and 2 years after surgery.	Participants will be followed for two years after they undergo surgery
Change in brain reward response to food cues	Two weeks before and two months after Roux-en-Y Gastric Bypass the brain reward response to the sight and smell of food will be assessed in a subset of 30 participants.	Before and 2 months after surgery

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Plasma levels of endocannabinoids and satiety hormones	Two weeks before and two months after Roux-en-Y gastric bypass surgery, fasted plasma levels of endocannabinoids, ghrelin, leptin, adiponectin and Glucagon-Like Peptide will be assessed in a subset of 30 participants.	Before and 2 months after surgery

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Descriptives	General subject characteristics, e.g. age, gender, restrained eating score and other lifestyle and medical parameters. For the subset of 30 patients that participate in the fMRI measurements: disinhibition scores will be assessed.	Before surgery
Appetite ratings	In a subset of 30 participants.	During fMRI measurements, i.e., before and two months after surgery
Olfactory performance	The Sniffin' Sticks test will be used to assess olfactory performance in the subset of 30 participants that will participate in the fMRI measurements. The sum-score of threshold, discrimination and identification tests will be used to determine if a participant is normosmic. A score of > 30 indicates a participant is normosmic.	At each fMRI measurement, i.e., before and two months after surgery
Development of BMI		Before and after surgery

Collaborators and Investigators

• Sponsor: Wageningen University
• Collaborators: Rijnstate Hospital
• Investigators: Principal Investigator: Suzanne EM de Bruijn, MSc, Wageningen University; Principal Investigator: Harriët FA Zoon, MSc, Wageningen University

Study record dates

Study Major Dates

• Study Start: July 1, 2014
• Primary Completion (Anticipated): September 1, 2017

Study Registration Dates

• First Submitted: February 5, 2014
• First Submitted That Met QC Criteria: February 17, 2014
• First Posted (Estimate): February 20, 2014

Study Record Updates

• Last Update Posted (Actual): May 23, 2017
• Last Update Submitted That Met QC Criteria: May 22, 2017
• Last Verified: May 1, 2017

More Information

Terms related to this study

• Other Study ID Numbers: NL45837.081.13