Oral Hygiene Procedures on Reduction of Oral Malodor

Effects of Various Oral Hygiene Procedures on the Reduction of Oral Malodor in Periodontally Healthy Patients

The purpose of the study is to evaluate the effect of various oral hygiene procedures on reduction of oral malodor.

Study Overview

• Status: Completed
• Conditions: Halitosis
• Intervention / Treatment: Drug: group 1: drug: chlorine dioxide; Device: group 2: device: small tooth brush for tongue cleaning

Detailed Description

Thirty volunteers who matched with including criteria were divided randomly into two groups. Both groups were instructed to brush their teeth with a scrubbing method for the first one week. Then, each group received the different additional oral malodor reduction regimen- in addition to tooth brushing tongue cleaning in one group and chlorine dioxide (ClO2) mouthwash in another group for three consecutive weeks. After that, all the participants were instructed to practice all the three oral hygiene procedures (tooth brushing, mouth washing, tongue cleaning) the last one week. Total volatile sulfur compounds (VSCs) measured by breathtron, tongue coating, plaque score and bleeding on probing (BOP) were outcomes of this study.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Phase 4

Contacts and Locations

Study Locations

• Japan
  • Tokyo, Japan, 113-8549
    • Department of oral health promotion

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Clinical diagnosis of oral malodor
• At least 20 functional teeth
• No systemic diseases
• No severe dental diseases

Exclusion Criteria:

• Habit of smoking and betel quid chewing
• Oral malodor by food and other craniofacial abnormalities
• Current use of any kind of mouthwash

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: group 1: drug; Drug: group 1: drug: chlorine dioxide 12ml chlorine dioxide (ClO2) mouthwash two times per day, for three consecutive weeks	Drug: group 1: drug: chlorine dioxide; First, each group practiced tooth brushing only for one week. After that each group was requested to do the following procedures. group 1 - additional use of 12ml chlorine dioxide (ClO2) mouthwash two times per day, for three consecutive weeks besides tooth brushing. At last, each group practiced all three methods of tooth brushing, tongue cleaning, mouth washing.; Other Names: ClO2Fresh®
Experimental: group 2: device: group 2: device: small tooth brush for tongue cleaning small tooth brush for tongue cleaning	Device: group 2: device: small tooth brush for tongue cleaning; First, each group practiced tooth brushing only for one week. After that each group was requested to do the following procedures. group 2 - additional practice of tongue cleaning by a small tooth brush two times per day, for three consecutive weeks besides tooth brushing. At last, each group practiced all three methods of tooth brushing, tongue cleaning, mouth washing.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Volatile sulfur compounds (VSCs)	Total volatile sulfur compounds was measured by Breathron®	5 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Bleeding on probing	gingival bleeding was recorded of bleeding was detected after examination with periodontal probe.	5 weeks
Tongue coating	tongue coating was evaluated by Winkel tongue coating index.	5weeks
Debris index	debris index was evaluated by oral hygiene index.	5 weeks

Collaborators and Investigators

• Sponsor: Ei Ei Aung
• Investigators: Principal Investigator: EiEi Aung, student, Department of oral health promotion

Publications and helpful links

General Publications

• Aung EE, Ueno M, Zaitsu T, Furukawa S, Kawaguchi Y. Effectiveness of three oral hygiene regimens on oral malodor reduction: a randomized clinical trial. Trials. 2015 Jan 27;16:31. doi: 10.1186/s13063-015-0549-9.

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): October 1, 2013
• Study Completion (Actual): November 1, 2013

Study Registration Dates

• First Submitted: April 7, 2014
• First Submitted That Met QC Criteria: April 11, 2014
• First Posted (Estimate): April 14, 2014

Study Record Updates

• Last Update Posted (Estimate): April 14, 2014
• Last Update Submitted That Met QC Criteria: April 11, 2014
• Last Verified: April 1, 2014

More Information

Terms related to this study

• Keywords: halitosis; chlorine dioxide; tongue cleaning
• Additional Relevant MeSH Terms: Signs and Symptoms, Digestive; Halitosis; Anti-Infective Agents; Disinfectants; Dental Disinfectants; Chlorine dioxide
• Other Study ID Numbers: OHP-018-EI