Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds

The purpose of the study is to evaluate the effect of various oral hygiene regimes on three volatile sulfur compounds.

Study Overview

• Status: Completed
• Conditions: Halitosis
• Intervention / Treatment: Other: chlorine dioxide; Other: small toothbrush for tongue cleaning

Detailed Description

Thirty male monk volunteers who matched with the including criteria were divided randomly into two groups. Both groups were practiced to brush their teeth with scrubbing method for one week. Then, each group were instructed to do different additional protocol regimen- group A have to do mouth washing and tooth brushing and group B have to practice tongue cleaning addition to tooth brushing for three weeks. At the fifth week, both groups were instructed to practice tooth brushing, mouth washing and tongue cleaning. Three different volatile sulfur compounds were measured by oral chroma. Tongue characteristics, oral examination were checked as the outcomes of this study.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Phase 4

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 30 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Clinical diagnosis of oral malodor
• No systemic diseases and no severe dental diseases
• At least 20 functional teeth

Exclusion Criteria:

• Risky oral habit (smoking and betel quid chewing)
• Current use of antibiotics or any drugs
• Current use of any kind of mouthwash

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Other: group A; Mouthwash (chlorine dioxide 12ml two times per day, for three weeks)	Other: chlorine dioxide; First week, subjects were instructed to do regular tooth brushing. After that group A was requested to use chlorine dioxide mouthwash two time per days for three weeks in addition to tooth brushing and then, one week for combination of tooth brushing, tongue cleaning and mouth washing.
Other: group B; Small toothbrush for tongue cleaning two times per day for three weeks	Other: small toothbrush for tongue cleaning; First week, subjects were instructed to do regular tooth brushing. After that group B was requested to brush their tongue with small toothbrush two time per days for three weeks in addition to tooth brushing and then, one week for combination of tooth brushing, tongue cleaning and mouth washing.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Three different volatile sulfur compounds	Investigator measured three different volatile sulfur compounds: hydrogen sulfide, methyl mercaptan, dimethyl sulfide concentrations (ng/10ml) by using Oral chroma.	up to 5weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Oral Health examination	As oral examination, investigator examined present teeth, DMF-T (decayed, missing and filled teeth)	up to 5weeks
Tongue coating characteristics	As tongue coating characteristics, investigator examined tongue coating score (by using winkle tongue coating index) at the baseline, one week later, four weeks later and five weeks later.	up to 5weeks
Number of teeth with bleeding on probing		up to 5weeks
Plaque index score		up to 5weeks

Collaborators and Investigators

• Sponsor: Tokyo Medical and Dental University

Study record dates

Study Major Dates

• Study Start: September 1, 2013
• Primary Completion (Actual): October 1, 2013
• Study Completion (Actual): November 1, 2013

Study Registration Dates

• First Submitted: February 8, 2016
• First Submitted That Met QC Criteria: February 18, 2016
• First Posted (Estimate): February 23, 2016

Study Record Updates

• Last Update Posted (Estimate): February 23, 2016
• Last Update Submitted That Met QC Criteria: February 18, 2016
• Last Verified: February 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Signs and Symptoms, Digestive; Halitosis; Anti-Infective Agents; Disinfectants; Dental Disinfectants; Chlorine dioxide
• Other Study ID Numbers: OHP-018-EI-2