Effects of Roux-en-Y Gastric Bypass on Gastro-intestinal Hormone Secretion and Brain Responses Food Pictures

Dynamic Effect of Gastrointestinal Hormones on Cerebral Mechanisms Involved in Brain Perception of Food Pictures After Bariatric Surgery

This is a cross-sectional study enrolling

• 11 weight-stable, formerly obese female patients 1-5 years after Roux-en-Y gastric Bypass (RYGB)
• 11 age- and weight-matched female subjects
• 10 normal weight (Body Mass Index 19-25 kg/m2) subjects The following measurements will be performed in each participants in basal conditions (after an overnight fast) and after ingestion of a standard meal
• electroencephalographic recordings of visually evoked potential after presentation of food- or non-food pictures
• plasma concentration of metabolites (glucose, fatty acids), glucoregulatory hormones (insulin, glucagon), gastro-intestinal hormones (Gastric Inhibitory Polypeptide (GIP), Glucagon-like Peptide-1 (GLP1), ghrelin,Cholecystokinin (CCK), and bile acids Aims of this observational study are
• to evaluate the effects of RYGB on brain perception of food related visual stimulation
• to search for relationships between RYGB effects on brain responses and gastro-intestinal hormone secretion

Study Overview

• Status: Completed
• Conditions: Obesity
• Intervention / Treatment: Other: standard test meal

• Study Type: Observational
• Enrollment (Actual): 31

Contacts and Locations

Study Locations

• Switzerland
  • VD
    • Lausanne, VD, Switzerland, CH-1001
      • CHUV-clinical research center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 50 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

• Sampling Method: Non-Probability Sample

Study Population

Formerly obese patients attending the obesity clinics of Lausanne University Hospital and healthy subjects resident in the Lausanne area

Description

Inclusion Criteria:

• good apparent health
• gender: female
• age 18-50
• non-smoker

Exclusion Criteria:

• diabetes or antidiabetic medication
• consumption of more than 50g alcohol per week
• vegetarian or any special diet

Study Plan

How is the study designed?

Design Details

• Observational Models: Case-Control
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
post Roux-en-Y-gastric bypass; Formerly obese females 1-5 years after gastric bypass	Other: standard test meal
matched controls; non-operated females age-and weight-matched to post Roux-en-Y-gastric bypass subjects	Other: standard test meal
healthy young controls; non overweight (BMI between 19 and 25 kg/m2) healthy females	Other: standard test meal

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes of visually-evoked EEG potentials after ingestion of a meal	Recording and analysis of visual evoked potentials (VEPs) while patients categorize photographs of foods and non-food kitchen utensils	basal, 120 min postprandial and 240 postprandial

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
changes in plasma triglyceride concentration after ingestion of a meal	Measurement of triglyceride concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)	basal, 90 min postprandial and 180 postprandial
Changes in plasma glucoincretins (GLP1 and GIP) concentrations after ingestion of a meal	Measurement of GLP1 and GIP concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)	basal, 90 min postprandial and 180 postprandial
Changes in plasma cholecystokinin concentrations after ingestion of a meal	Measurement of cholecystokinin concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)	basal, 90 min postprandial and 180 postprandial
Changes in plasma bile acids concentrations after ingestion of a meal	Measurement of bile acids concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)	basal, 90 min postprandial and 180 postprandial
changes in plasma glucoregulatory status after ingestion of a meal	Measurement of glucose, insulin, glucagon and non-esterified fatty acid concentrations at 30-60 min intervals in basal conditions (after an overnight fast) and over 6 hours after ingestion of a standard meal)	basal, 90 min postprandial and 180 postprandial

Collaborators and Investigators

• Sponsor: University of Lausanne

Study record dates

Study Major Dates

• Study Start: January 1, 2011
• Primary Completion (Actual): March 1, 2012
• Study Completion (Actual): March 1, 2012

Study Registration Dates

• First Submitted: June 4, 2014
• First Submitted That Met QC Criteria: June 6, 2014
• First Posted (Estimate): June 10, 2014

Study Record Updates

• Last Update Posted (Estimate): June 10, 2014
• Last Update Submitted That Met QC Criteria: June 6, 2014
• Last Verified: June 1, 2014

More Information

Terms related to this study

• Keywords: bile acids; roux-en-Y-gastric bypass; brain responses to food; gastrointestinal hormones
• Other Study ID Numbers: 219/09

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No