High Intensity Interval Training in Geriatrics (HIITERGY)

High Intensity Interval Training for thE Rehabilitation of Geriatric Patients - a Feasibility Pilot studY.

This is a pilot study for evaluating the feasibility of using High Intensity Interval Training in geriatric hospitalized patients compared to the standard current rehabilitation practice.

Study Overview

• Status: Completed
• Conditions: Muscle Weakness; Gait, Unsteady
• Intervention / Treatment: Other: high intensity interval training-HIIT; Other: Traditionnal group rehabilitation

Detailed Description

High Intensity Interval Training (HIIT) has shown a superior effectiveness and efficiency when compared to Moderate Intensity Continuous Training (MICT) in several types of patients and in healthy subjects. There are no data on HIIT in a general geriatric population. This study is a pilot study evaluating the feasibility of using HIIT in geriatric hospitalized patients compared to the standard current rehabilitation practice without HIIT. It is our desire to perform a larger randomized comparative trial between HIIT and MICT if the pilot study proves its feasibility.

• Study Type: Interventional
• Enrollment (Actual): 100
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Switzerland
  • Thônex
    • Geneva, Thônex, Switzerland, 1226
      • Hôpital des Trois-Chêne (HUG)

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients aged 65 years and older hospitalized for rehabilitation after an acute medical condition
• Expected duration of the rehabilitation ≥ 2 weeks
• Ability to follow instructions to perform a Timed up and Go Test
• Ability to perform exercises
• Willing to participate in 4 sessions of HIIT per week for 2 weeks

Exclusion Criteria:

• Any acute condition with tachycardia, hypotension or fever.
• Abnormal cycle ergometer stress test with
• significant ECG modification
• decrease of more than 20 mmHg of the blood pressure with exercise
• angina
• ST depression at a workload <6 METs
• Inability to reach an intensity of 15/20 in the Borg's scale of perceived exertion
• Any unresolved acute medical or surgical condition of the following kind:
• acute heart failure
• acute coronary syndrome < 1 month
• strole < 1 month
• active pericarditis / myocarditis / endocarditis
• thromboembolic disease with < 2 weeks of anticoagulation
• acute infection requiring intravenous treatment
• ongoing intravenous perfusion
• surgery < 2 months
• recent bone fracture
• Previous episode of primary cardiac arrest (ie, cardiac arrest that did not occur in the presence of an acute myocardial infarction or during a cardiac procedure).
• Severe heart failure (NYHA III and IV)
• Severe stenotic or regurgitant valvular disease
• Uncontrolled hypertension at rest (SBP≥160mmHg, DBP≥100mmHg)
• Uncontrolled dysrhythmia
• Non-sustained ventricular tachycardia with exercise
• Implanted defibrillator
• Obstructive cardiomyopathy
• Resting HR > 100/min
• Severe peripheral artery disease
• Severe COPD (VEMS < 50%)
• Exercise-induced asthma
• Oxygen dependency
• Muscular-skeletal anomaly that may limit exercise participation
• Delirium
• Inability to follow instructions
• Inability to consent

Study Plan

How is the study designed?

Design Details

• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: high intensity interval training-HIIT; HIIT 4 times a week, 30 minutes duration	Other: high intensity interval training-HIIT; HIIT 4 times a week, 30 minutes duration
Active Comparator: Traditionnal rehabilitation; Traditionnal group rehabilitation 3 times a week, 1 hour duration.	Other: Traditionnal group rehabilitation; Traditionnal group rehabilitation, 3 times a week, 1 hour duration

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Proportion of patients who complete the rehabilitation program	2 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Distance walked in the 6MWT		2 weeks
Muscle strength assessed for the upper and lower extremities	upper extremity : handgrip strength using the Baseline Pneumatic Bulb Hand Dynamometer Pinch Gauge; Lower exremity : knee flexion & extension and ankle flexion & extension using Microfet2™portable Dynamometer.	2 weeks
Step variability changes as a measure of quality of ambulation	Variability measured with GaitRite step analysis system	2 weeks

Collaborators and Investigators

• Sponsor: University Hospital, Geneva
• Investigators: Principal Investigator: Jean-Luc Reny, MD, PhD, Hôpitaux Universitaires de Genève

Publications and helpful links

General Publications

• Pires Peixoto R, Trombert V, Poncet A, Kizlik J, Gold G, Ehret G, Trombetti A, Reny JL. Feasibility and safety of high-intensity interval training for the rehabilitation of geriatric inpatients (HIITERGY) a pilot randomized study. BMC Geriatr. 2020 Jun 5;20(1):197. doi: 10.1186/s12877-020-01596-7.

Study record dates

Study Major Dates

• Study Start: May 1, 2014
• Primary Completion (Actual): November 1, 2015
• Study Completion (Actual): February 1, 2016

Study Registration Dates

• First Submitted: November 7, 2014
• First Submitted That Met QC Criteria: December 11, 2014
• First Posted (Estimate): December 17, 2014

Study Record Updates

• Last Update Posted (Estimate): November 3, 2016
• Last Update Submitted That Met QC Criteria: November 2, 2016
• Last Verified: November 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Nervous System Diseases; Neurologic Manifestations; Musculoskeletal Diseases; Muscular Diseases; Neuromuscular Manifestations; Muscle Weakness; Gait Disorders, Neurologic
• Other Study ID Numbers: 13-257 (Other Identifier: University of Central Florida)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No