- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02384161
Exercise Intermittent Isometric Handgrip and Blood Flow Restriction
Exercise Intermittent Isometric Handgrip Associated With Different Levels of External Vascular Compression: Acute Effects on Neuromuscular Response
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Muscle fatigue is a process widely disbelieved and studied in the literature. Isometric handgrip exercises have been widely utilized to explain the effects of fatigue on the strength and activation of the muscles involved in certain exercises. Among the many factors that can influence the process of muscular fatigue, blood flow available at the time of exercise is an aspect of fundamental importance, as some studies demonstrate changes in the pattern of muscle recruitment and strength recovery when the exercise is performed associated with an external obstruction of blood flow.
Resistance exercise associated with partial obstruction of blood flow (ischemic exercise) is gaining notoriety in the scientific environment, mainly due to strong evidence indicating that such activity can increase strength and muscle hypertrophy, even when performed with low intensity loads. The underlying neuromuscular mechanisms such effects are still partially unknown, and some studies have shown differences in the recruitment of motor units during its execution, and the relationship fatigue-strength after ischemic resistance exercise. Nevertheless, there are still some gaps in the literature regarding the neuromuscular responses during and after unilateral intermittent isometric handgrip protocols to failure in the associated task to partial obstruction of blood flow.
Evidence suggests that the total obstruction of blood flow decreases performance and accelerates the recovery of the isometric strength after fatigue protocols, but the effects of partial obstruction on these variables remain unknown. In the above so far, it seems that isometric fatigue protocols associated with remote obstruction (away from the venue of the exercise) blood flow can influence acutely in strength members at a distance, but it is not known as a protocol unilateral isometric fatigue associated with partial and complete obstruction of blood flow can influence acutely the strength of the contralateral limb (ie, not subject to any type of exercise). Thus, the realization of this study is justified by the possibility of answering these questions still little studied, with regard to neuromuscular factors of ischemic resistance training.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Pernambuco
-
Recife, Pernambuco, Brazil, 50670-901
- Federal University of Pernambuco
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Volunteers classified as irregularly active or active
- Volunteers ranked within the normal range (18.5 to 24.9 kg / m2), the Body Mass Index (BMI).
Exclusion Criteria:
- Smokers volunteers will be excluded, that are using vasoactive drugs and having fracture history in upper limbs; hypertension, venous insufficiency, cardiac insufficiency or any other cardiovascular disease; epilepsy, stroke or some other neurological disease or any other condition that prevents you from performing the exercise protocol.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Crossover Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Total RBF + Exercise Isometric
Volunteers will undergo a year of intermittent isometric handgrip (intervention) in the dominant member associated with a total obstruction of blood flow, which will be conducted through a "cuff" pressure applied to the proximal region of the dominant limb.
|
Intermittent isometric exercise is characterized by an interval muscle contraction (one period and another relaxed contracted period) in which there is no generation of voltage change in the length of the muscle fiber.
|
Experimental: Partial RBF + Exercise Isometric
Volunteers will undergo a year of intermittent isometric handgrip (intervention) in the dominant member associated with a partial obstruction of blood flow, which will be conducted through a "cuff" pressure applied to the proximal region of the dominant limb.
|
Intermittent isometric exercise is characterized by an interval muscle contraction (one period and another relaxed contracted period) in which there is no generation of voltage change in the length of the muscle fiber.
|
Placebo Comparator: Free BR + Exercise Isometric
Volunteers will undergo a year of intermittent isometric handgrip (intervention) in the dominant limb with the free blood flow.
A 'cuff' pressure on the member of the proximal region, but with a pressure that will not interfere with blood flow will be applied.
|
Intermittent isometric exercise is characterized by an interval muscle contraction (one period and another relaxed contracted period) in which there is no generation of voltage change in the length of the muscle fiber.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Maximal voluntary isometric strength.
Time Frame: 3 months
|
Recovery of maximal voluntary isometric strength in the dominant member.
|
3 months
|
Time to task failure.
Time Frame: 3 months
|
Recovery of time to task failure in the dominant member.
|
3 months
|
electromyography activity.
Time Frame: 3 months
|
Recovery electromyographic activity in the dominant member.
|
3 months
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Contralateral maximum voluntary isometric strength (non-dominant limb).
Time Frame: 3 months
|
Contralateral maximum voluntary isometric strength (non-dominant limb).
|
3 months
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- UFPernambucoMK
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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