Interval Training in Bipolar Disorder (HIIT)

July 27, 2022 updated by: Alberto Souza de Sá Filho, Universidade Federal do Rio de Janeiro

Can the High Intensity Interval Training (HIIT) Deliver Superior and Rapid Decrease of Symptoms of Bipolar Disorder? a Controlled and Randomized Study

Our main objective will be to evaluate the chronic effects (12 weeks) of high-intensity interval training compared to moderate intensity (same total work) on reducing the symptoms of bipolar disorder, cortical changes, as well as on the VO2max. In addition, the investigators will establish what influence of gain to VO2max has on reducing symptoms.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

Physical exercise has significant effects on health promotion and the consequent reduction of the severity of bipolar disorder (BD). This review establishes a pattern of response of exercise and potential impact on the pathophysiology of BD; , as well as, produces hypotheses on how acute and chronic effect of exercises may act differently; and provides future perspectives with the focus of the exercise as an important and innovative model of treatment for BD and mental disorder. A critical evaluation of the literature was undertaken including the influence of exercise on health promotion in patients with mental disorders, neurochemical behavior exercise-induced, as well as reflective introduction of news perspectives of training control in severe exercise domain. The exercise induces significant changes in monoaminergic after, and with long-term training, and work with a threshold of exercise can modulate positive effects on mood. Fast adaptive effects from the high intensity interval training should be considered in BD patients. However, there must be caution in his administration. We speculate that exercise may be a way of maintaining euthymia in the case of BD, making it less vulnerable patient to stay longer at a time of neutrality. Future research is needed to adopt a training strategy that is both time efficient in the different areas and adequate for the population in question.

Study Type

Interventional

Enrollment (Actual)

36

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Brazil
      • Rio de Janeiro, Brazil
        • Institute of Psychiatry (IPUB)

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 59 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Bipolar Criteria (DSM-IV),
  • sedentary lifestyle

Exclusion Criteria:

  • 60 and over,
  • Cardiovascular Disease,
  • Panic disorder,
  • Metabolic syndrome Diagnosis

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Interval Training
6 stimulous (30 s) at 100% VO2Max/ 1 min 30 s to rest, 19 minutes (total exercise), 3 times/ week, 12 weeks
Behavioral: Interval Training
High Intensity Interval Training at 100% VO2Max
Other Names:
  • HIT
  • High intensity interval training
  • HIIT
Behavioral: Continuous Training
Continuous Stimulous at 60% VO2Max
Other Names:
  • Moderate Training
  • Endurance
Active Comparator: Continuous Training
Running at 60% VO2Max, 25 minutes (total exercise), 3 times/week, 12 weeks
Behavioral: Interval Training
High Intensity Interval Training at 100% VO2Max
Other Names:
  • HIT
  • High intensity interval training
  • HIIT
Behavioral: Continuous Training
Continuous Stimulous at 60% VO2Max
Other Names:
  • Moderate Training
  • Endurance
Sham Comparator: Control
Only Dependent Variables Measures
Behavioral: Control
Only Dependent Variables Measures
Other Names:
  • No Intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Symptom Scales (Hamilton and Young)
Time Frame: 0 week, 6 week, 12 week
Variable Measured to reduction of symptoms
0 week, 6 week, 12 week

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Cortical Changes (EEG) - Loreta
Time Frame: 0 week, 6 week, 12 week
Measured to evaluate changes due to training
0 week, 6 week, 12 week
VO2Max
Time Frame: 0 week, 6 week, 12 week
Variable Measured to assess cardiovascular improvement
0 week, 6 week, 12 week
Cognitive Function
Time Frame: 0 week, 6 week, 12 week
Executive Function, Time Reaction, Atention, and Memory
0 week, 6 week, 12 week

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Universidade Federal do Rio de Janeiro

Investigators

  • Study Director: Sérgio E. Machado, PhD, Universidade Federal do Rio de Janeiro

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

August 1, 2015

Primary Completion (Actual)

July 1, 2017

Study Completion (Actual)

July 1, 2017

Study Registration Dates

First Submitted

July 11, 2015

First Submitted That Met QC Criteria

July 14, 2015

First Posted (Estimate)

July 15, 2015

Study Record Updates

Last Update Posted (Actual)

July 29, 2022

Last Update Submitted That Met QC Criteria

July 27, 2022

Last Verified

July 1, 2022

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • UFRJ-01

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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