Afatinib, Paclitaxel, 2nd Line, Advanced Gastric Cancer

An Open-label, Multicenter Phase II Study of Afatinib Plus Weekly Taxol as Second Line Treatment for Advanced/Recurrent Gastric and Gastroesophageal Junction Cancer

For the gastric cancer, paclitaxel is recommended as salvage standard treatment. Afatinib is a novel, potent, small ErbB family blocker that covalently binds and irreversibly blocks signaling through activated EGFR, HER2 and ErbB4 receptors, as well as the transphosphorylation of ErbB3. The investigators suggest a randomized phase II trial of afatinib plus weekly taxol(paclitaxel) for previously treated EGFR positive gastric cancer patients. The aim of current trial is to evaluate the antitumor efficacy of afatinib for target enriched patients in gastric cancer.

Study Overview

• Status: Completed
• Conditions: Gastric Cancer; Gastroesophageal Junction Cancer
• Intervention / Treatment: Drug: afatinib; Drug: paclitaxel

• Study Type: Interventional
• Enrollment (Anticipated): 72
• Phase: Phase 2

Contacts and Locations

Study Locations

• Korea, Republic of
  • Seoul, Korea, Republic of, 120-752
    • Severance Hospital, Yonsei University Health System, Yonsei Cancer Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 19 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

1. Histologically or cytologically confirmed locally advanced or metastatic gastric cancer and gastroesophageal junction cancer
2. EGFR 2+ or 3+ expression (immunohistochemistry)
3. ECOG performance status of 0 to 1
4. Male or female; ≥ 19 years of age
5. Documented disease progression after one prior therapy, in locally advanced or metastatic setting
6. patients received last adjuvant chemotherapy less than six months can be enrolled into this study
7. Her2 positive patients must be progressed after prior trastuzumab based chemotherapy
8. Subjects with measurable lesion (using RECIST 1.1 criteria)

9. Subjects who meet the following criteria:

   • Absolute neutrophil count (ANC) ≥ 1000 /µL (*ANC = Neutrophil segs ＋ Neutrophil bands)
   • Platelet count ≥ 80,000/ µL
   • Serum creatinine < 1.5 x upper limit of normal (ULN) or Creatinine clearance ≥50 mL/min using Cockcroft, Gault method
   • AST (SGOT) and ALT (SGPT) : 3 x upper limit of normal (ULN) (If there is Liver Metastasis : 5 x upper limit of normal (ULN))
   • Total bilirubin : 1.5 x upper limit of normal (ULN)
10. Provision of written informed consent prior to any study procedure

Exclusion Criteria:

1. Any unresolved chronic toxicity greater than CTC grade 2 from previous anticancer therapy.
2. Any previous chemotherapy or immunotherapy within 2 weeks
3. Any major operation or irradiation within 4 weeks of baseline disease assessment
4. Two or more previous systemic cytotoxic chemotherapy (adjuvant chemotherapy is not counted)
5. Any clinically significant gastrointestinal abnormalities which may impair intake or absorption of the study drug
6. Previously taxol(paclitaxel)-exposed patients
7. Subjects with symptomatic central nervous system (CNS) metastases who are neurologically unstable or have required increasing doses of steroids within the 2 weeks prior to study entry to manage CNS symptoms
8. Other co-existing malignancies or malignancies diagnosed within the last 3 years with the exception of basal cell carcinoma, thyroid cancer or cervical cancer in situ.
9. Subjects with an uncontrolled major cardiovascular disease (including AMI within 12 months, unstable angina within 6 months, over NYHA class III congestive heart failure, congenital long QT syndrome, 2° or more AV Block and uncontrolled hypertension)
10. Pregnant or lactating female
11. Patients with contraindicated medication
12. History of interstitial lung disease (ILD) or presence of ILD on chest X-ray
13. Evidence of any other significant clinical disorder or laboratory finding that makes it undesirable for the patient to participate in the study

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: afatinib plus paclitaxel	Drug: afatinib; Afatinib 40mg daily oral administration; Drug: paclitaxel; Paclitaxel 80mg/m2 IV weekly (day 1,8,15)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
compare progression free survival as measured by RECIST 1.1	To identify antitumor activity of afatinib plus weekly taxol(paclitaxel) and explore predictive biomarker	Every 6 weeks until progression, an expected average of 10 months

Secondary Outcome Measures

Outcome Measure	Time Frame
antitumor efficacy as measured by RECIST 1.1	every 6 weeks until progression, an expected average of 10 months
safety as measured by CTCAE	every 3 weeks until progression, an expected average of 10 months

Collaborators and Investigators

• Sponsor: Yonsei University
• Investigators: Principal Investigator: Sun Young Rha, Severance Hospital, Yonsei University Health System, Yonsei Cancer Center

Study record dates

Study Major Dates

• Study Start: July 1, 2016
• Primary Completion (Actual): December 31, 2021
• Study Completion (Actual): December 20, 2022

Study Registration Dates

• First Submitted: July 8, 2015
• First Submitted That Met QC Criteria: July 15, 2015
• First Posted (Estimate): July 17, 2015

Study Record Updates

• Last Update Posted (Actual): January 27, 2023
• Last Update Submitted That Met QC Criteria: January 26, 2023
• Last Verified: January 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Neoplasms; Neoplasms by Site; Gastrointestinal Neoplasms; Digestive System Neoplasms; Gastrointestinal Diseases; Stomach Diseases; Stomach Neoplasms; Molecular Mechanisms of Pharmacological Action; Enzyme Inhibitors; Antineoplastic Agents; Tubulin Modulators; Antimitotic Agents; Mitosis Modulators; Antineoplastic Agents, Phytogenic; Protein Kinase Inhibitors; Paclitaxel; Afatinib
• Other Study ID Numbers: 4-2015-0244