cAMP Signaling and Muscle Adaptations

October 25, 2017 updated by: Morten Nielsen, University of Copenhagen
The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Anticipated)

72

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Denmark
      • Copenhagen, Denmark, 2100
        • Recruiting
        • Department of Nutrition, Exercise and Sports
        • Contact:
      • Copenhagen, Denmark, 2400
        • Recruiting
        • Bispebjerg University Hospital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • healthy young men
  • 18-35 years of age
  • Informed consent
  • Active 2-5 hours of training pr. week
  • Maximal oxygen uptake (ml/min/kg) of 40-60
  • Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2

Exclusion Criteria:

  • Smoker
  • Allergy towards study drugs
  • Chronic disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: BASIC_SCIENCE
  • Allocation: RANDOMIZED
  • Interventional Model: PARALLEL
  • Masking: TRIPLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
PLACEBO_COMPARATOR: Placebo
Drug: Placebo
Other: Resistance Training
Other: No training
Other: Endurance training
EXPERIMENTAL: Terbutaline
Beta2-adrenergic stimulation with terbutaline
Other: Resistance Training
Other: No training
Other: Endurance training
Drug: Terbutaline
EXPERIMENTAL: Clenbuterol
Beta2-adrenergic stimulation with clenbuterol
Drug: Clenbuterol
Other: No training

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Muscle hypertrophy (lean body mass in Kilograms)
Time Frame: 2 days
Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)
2 days

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Energy turnover (ml/min or mmol/kg dry weight muscle)
Time Frame: 1 day
Pulmonary gas exchange and lactate and glycogen will be measured in muscle biopsies obtained before and after intense exercise
1 day

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Copenhagen

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

July 1, 2015

Primary Completion (ACTUAL)

June 30, 2017

Study Completion (ANTICIPATED)

October 1, 2017

Study Registration Dates

First Submitted

September 13, 2015

First Submitted That Met QC Criteria

September 22, 2015

First Posted (ESTIMATE)

September 23, 2015

Study Record Updates

Last Update Posted (ACTUAL)

October 26, 2017

Last Update Submitted That Met QC Criteria

October 25, 2017

Last Verified

October 1, 2017

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • TUD

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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