Effects of Standing and Light-intensity Activity on Ambulatory Blood Pressure and Blood Glucose

This study aims to test the short-term effects of intermittent standing, slow cycling and slow walking, compared to sitting, on continuous blood glucose and ambulatory blood pressure among pre-hypertensive and pre-diabetic adults.

Study Overview

• Status: Completed
• Conditions: Hypertension; Diabetes; Sleep
• Intervention / Treatment: Other: Maintaining posture and energy expenditure; Other: Increasing energy expenditure; Other: Changing posture; Other: Increasing energy expenditure and changing posture

Detailed Description

This study will enroll 10 adults who will each complete four experimental conditions in random order. Each of the four experimental conditions are as follows: 1) sit continuously for 8 hours in a simulated office environment, 2) break-up sitting time with standing based on set hourly intervals, 3) break-up sitting time with slow-walking on a treadmill desk based on set hourly intervals, 4) increase energy expenditure by slow cycling based on set hourly intervals. Participants will completed each condition one week apart and dietary intake will be standardized by giving participants the same meals during each intervention condition. Study measures will include: anthropometrics (height and weight), blood pressure, fasting glucose, 24-continuous glucose monitoring, full-day ambulatory blood pressure monitoring, cognitive testing (cognitive performance), energy expenditure, physical activity via accelerometer, sleep via accelerometer, and heart rate.

• Study Type: Interventional
• Enrollment (Actual): 10
• Phase: Phase 3

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 55 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• pre-hypertensive (systolic blood pressure 120-139 mmHg, or diastolic blood pressure 80-89 mmHg)
• impaired fasting glucose (5.6-6.9 mmil/L)
• not meeting the physical activity guidelines for adults (>=150 min/wk of moderate-to-vigorous physical activity)

Exclusion Criteria:

• smoking, pregnancy, known coronary heart disease, orthopedic limitations for performing physical activity, taking medications to control high blood pressure or high blood glucose, special dietary requirements, and being advised by a doctor to avoid prolonged periods of sitting.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Sitting; Participants will sit continuously for 8 hours in a simulated office environment	Other: Maintaining posture and energy expenditure; Participants will sit continuously for 8-hrs during a simulated office environment
Experimental: slow cycling; Participants will cycle at regular hourly intervals during an 8-hr simulated office environment	Other: Increasing energy expenditure; Participants will cycle slowly while seated in prescribed hourly intervals. This condition will increase energy expenditure while keeping a sitting posture
Experimental: standing; Participants will change posture (from sitting to standing) during hourly intervals for an 8-hr period in a simulated office environment	Other: Changing posture; Participants will transition from sitting to standing in prescribed hourly intervals. This condition will change posture (sit to stand) while maintaining low energy expenditure
Experimental: slow walking; Participants will transition from sitting to slow walking on a treadmill desk at regular hourly intervals during an 8-hr period in a simulated office environment	Other: Increasing energy expenditure and changing posture; Participants will transition from sitting to a walking workstation in prescribed hourly intervals. This condition will both increase energy expenditure and change posture.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Evidence of change in blood pressure following changes in posture and increasing energy expenditure	single-day intervention
Evidence of change in blood glucose following changes in posture and increasing energy expenditure	single-day intervention

Collaborators and Investigators

• Sponsor: Arizona State University

Study record dates

Study Major Dates

• Study Start: July 1, 2014
• Primary Completion (Actual): April 1, 2015
• Study Completion (Actual): April 1, 2015

Study Registration Dates

• First Submitted: November 24, 2015
• First Submitted That Met QC Criteria: November 27, 2015
• First Posted (Estimate): November 30, 2015

Study Record Updates

• Last Update Posted (Estimate): November 30, 2015
• Last Update Submitted That Met QC Criteria: November 27, 2015
• Last Verified: November 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Cardiovascular Diseases; Vascular Diseases; Hypertension
• Other Study ID Numbers: 1306009298