The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward (DEXDER)

January 8, 2016 updated by: Eric Doucet, University of Ottawa
The purpose of this study is to determine how the modality of energy depletion can differently impact appetite hormones, ad libitum food intake, food hedonics, and olfaction.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The objectives of the current randomized controlled study were to examine how the modality of an acute 3 day isocaloric -25% energy depletion by dieting alone or by aerobic exercise alone differently impacts appetite and appetite-related hormones, ad libitum energy intake (EI), food hedonics and food reward, and olfaction. It was hypothesized that independent of modality of depletion, that relative to the control, there would be increased ad libitum feeding and food reward, improvements in smell performance, and a decline in fasting leptin and increase in fasting total ghrelin. It was also hypothesized that the increased food reward would prove to be a predictor of ad libitum EI and that relative to the depletion by aerobic exercise alone, the depletion by diet alone would produce greater compensatory increases in appetite, ad libitum EI, and food reward.

Statistics

To test for differences in body weight, plasma hormone concentrations, relative-reinforcing value of food (RRVF), and olfaction across each condition of the study, repeated measures ANOVA controlling for day 1 as a covariate was employed. Pairwise comparisons at day 4 using Sidak adjustment to account for multiple comparisons are reported when the ANOVA was significant. One way repeated measures ANOVAs with Sidak adjustments for multiple comparisons were used to test for differences in variables measured only at day 4: body composition (fat mas, %Fat, and fat free mass), appetite, palatability, and ad libitum EI.

Study Type

Interventional

Enrollment (Actual)

10

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

  • Free from any illness that could influence outcome of the experiment
  • Weight-stable for >6months
  • aged between 18-40 years

Exclusion Criteria:

  • diabetic
  • smoker
  • medication

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: DIET ARM
A 25% energy depletion (daily for 3 days) induced by reducing the amount of energy intake that would otherwise keep the individual in energy balance.
Behavioral: DIET
25% Energy Depletion by Diet only for 3 Days
Active Comparator: EX ARM
A 25% energy depletion (daily for 3 days) induced by performing aerobic exercise at 50% of V02max.
Behavioral: EX
25% Energy Depletion by Exercise only for 3 Days

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in Ad Libitum Energy Intake at Buffet Lunch--total kcals consumed at lunch meal measured to nearest 0.5grams.
Time Frame: Day 1 and Day 4 of each study arm (DIET and EX)
Ad libitum measure of energy intake at lunch time at Day 1 and Day 4 of study
Day 1 and Day 4 of each study arm (DIET and EX)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in fasting measure of Leptin
Time Frame: Day 1 and Day 4 of each study arm (DIET and EX)
One fasting sample of plasma Leptin
Day 1 and Day 4 of each study arm (DIET and EX)
Change in fasting measure of Ghrelin
Time Frame: Day 1 and Day 4 of each study arm (DIET and EX)
One fasting sample of plasma Ghrelin taken at Day 1 and Day 4 of study
Day 1 and Day 4 of each study arm (DIET and EX)
Change in Relative-Reinforcing Value of Food as measured by food points earned during a computerized behavioral choice tast
Time Frame: Day 1 and Day 4 of each study arm (DIET and EX)
Computer task measuring reinforcing value of preferred snack food and preferred fruit at Day 1 and Day 4 of study
Day 1 and Day 4 of each study arm (DIET and EX)
Olfaction--Odor Detection Threshold measured by Sniffin Sticks odorized pens
Time Frame: Day 1 and Day 4 of each study arm (DIET and EX)
Measure of odour threshold for n-butanol taken at Day 1 and Day 4 of study
Day 1 and Day 4 of each study arm (DIET and EX)

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Ottawa

Investigators

  • Principal Investigator: Eric Doucet, PhD, University of Ottawa

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2009

Primary Completion (Actual)

March 1, 2012

Study Completion (Actual)

March 1, 2012

Study Registration Dates

First Submitted

January 6, 2016

First Submitted That Met QC Criteria

January 8, 2016

First Posted (Estimate)

January 12, 2016

Study Record Updates

Last Update Posted (Estimate)

January 12, 2016

Last Update Submitted That Met QC Criteria

January 8, 2016

Last Verified

January 1, 2016

More Information

Terms related to this study

Other Study ID Numbers

  • H09-09-03

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Exercise

Clinical Trials on DIET

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mauritania

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe