Effect of Resistant Wheat Starch on Subjective Appetite and Food Intake in Healthy Adults

February 18, 2016 updated by: James Hollis, Iowa State University
A randomized, single-blind, cross-over study was conducted to determine the effect of replacing standard wheat flour (SWF) with resistant wheat starch (RWS) on markers of appetite and food intake in healthy adults.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

31

Phase

  • Not Applicable

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 35 years (Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • BMI 18.5-29.9 kg/m2
  • Regular breakfast consumers (>5 days/week)

Exclusion Criteria:

  • not weight stable (?3 kg weight change in previous 3 months)
  • use/used tobacco products
  • presence of acute or chronic illness
  • restrained eater (>13 on the restraint section of the three-factor eating questionnaire)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Allocation: Randomized
  • Interventional Model: Crossover Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: Control (SWF)
Standard Wheat Flour (SWF) Muffins
Experimental: Resistant Starch Type 4
Resistant Wheat Starch Muffins
Dietary supplement: Resistant Starch Type 4
single dose 26g fiber given at the breakfast meal
Other Names:
  • Fibersym

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Caloric intake
Time Frame: Single Day
calories consumed at post-treatment lunch meal and total calories consumed on the treatment day
Single Day

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Visual analogue scale measures of subjective appetite
Time Frame: Single Day
0-100mm scale to assess hunger, fullness, thirst, desire to eat and prospective consumption
Single Day
Serum concentrations of biomarkers of appetite
Time Frame: 150 minutes
CCK, ghrelin, PYY3-36 and GLP-1
150 minutes
Plasma concentrations of biomarkers of glycemic response
Time Frame: 150 minutes
Glucose, Insulin, GLP-1
150 minutes

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Iowa State University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

January 1, 2012

Primary Completion (Actual)

January 1, 2013

Study Completion (Actual)

August 1, 2014

Study Registration Dates

First Submitted

February 7, 2016

First Submitted That Met QC Criteria

February 18, 2016

First Posted (Estimate)

February 24, 2016

Study Record Updates

Last Update Posted (Estimate)

February 24, 2016

Last Update Submitted That Met QC Criteria

February 18, 2016

Last Verified

February 1, 2016

More Information

Terms related to this study

Keywords

Other Study ID Numbers

  • IowaSU

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

Undecided

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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