- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02787616
Genetic Basis of Rosacea
September 24, 2019 updated by: Anne Chang, Stanford University
Validation of Candidate Rosacea Genes By Targeted Interrogation of Alleles and Assessment of Rosacea Co-morbidities
Rosacea is a common disease characterized by inflammation and vascular abnormalities of the facial skin and ocular surface.
The exact pathogenesis of papulopustular rosacea is not well understood and current methods to treat this disease are often unsatisfactory.
The purpose of this study is to develop gene expression profiles of papulopustular rosacea compared to those of normal skin.
The investigators hope to better understand the abnormal gene functions that might contribute to this condition.
This understanding may lead to the development of additional and better treatments for rosacea.
Study Overview
Study Type
Observational
Enrollment (Actual)
306
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
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California
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Redwood City, California, United States, 94603
- Stanford Dermatology
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (ADULT, OLDER_ADULT)
Accepts Healthy Volunteers
Yes
Genders Eligible for Study
All
Sampling Method
Non-Probability Sample
Study Population
300 individuals will be enrolled, 150 with dermatologist verified rosacea and 150 without rosacea.
Description
Eligibility Criteria for Rosacea Group:
Inclusion criteria for rosacea participants:
- Clinical signs and symptoms of rosacea (papulopustular or erythrotelangiectatic subtypes) present at enrollment as determined by the investigator
- All four grandparents of European descent
- Fitzpatrick skin type I or II
- Age 18 years or older
Exclusion criteria for rosacea participants:
- Unable or unwilling to provide written informed consent
- Concomitant facial or medical condition that obscures diagnosis of rosacea (such as malar erythema from lupus erythematosus)
- Acne vulgaris
- Unable or unwilling to provide peripheral blood sample (a few teaspoons)
- Inability for investigator to verify rosacea diagnosis on clinical examination due to rosacea treatment(s) leading to complete lack of signs and symptoms (such prior laser treatments, systemic tetracycline usage, etc.)
- Use of topical prescription medications or procedures to the face within one month of enrollment
- Women who are pregnant or lactating
Eligibility Criteria for Non-Rosacea Group:
Inclusion criteria for control participants:
- No history of rosacea
- No clinical signs or symptoms of rosacea
- No family history of rosacea
- All four grandparents of European descent
- Fitzpatrick skin type I or II
- Age 18 years or older
Exclusion criteria for control participants:
- Unable or unwilling to provide written informed consent
- Acne vulgaris
- Unable or unwilling to provide peripheral blood sample (a few teaspoons)
- Women who are pregnant or lactating
- Use of topical prescription medications or procedures to the face within one month of enrollment
- Skin conditions that might interfere with interpretation of procedure results (at the discretion of the investigator)
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Rosacea Group
|
cheek swab for DNA sampling
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Non-Rosacea Group
|
cheek swab for DNA sampling
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Targeted interrogation of alleles and assessment of rosacea co-morbidities.
Time Frame: Up to 2 years
|
Up to 2 years
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (ACTUAL)
April 13, 2012
Primary Completion (ACTUAL)
November 16, 2018
Study Completion (ACTUAL)
November 16, 2018
Study Registration Dates
First Submitted
April 18, 2016
First Submitted That Met QC Criteria
May 26, 2016
First Posted (ESTIMATE)
June 1, 2016
Study Record Updates
Last Update Posted (ACTUAL)
September 26, 2019
Last Update Submitted That Met QC Criteria
September 24, 2019
Last Verified
September 1, 2019
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- R15006
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Rosacea
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-
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