Technical Development of Multi-Parametric Renocerebral MRI

The purpose of the study is to investigate the associations of the age-related changes in the brain, kidneys and cognitive performance in healthy adults by utilizing multiple anatomic and functional MRI methods along with a battery of cognitive tests.

Study Overview

• Status: Recruiting
• Conditions: Aging
• Intervention / Treatment: Other: MRI; Other: Group 4

• Study Type: Observational
• Enrollment (Estimated): 120

Contacts and Locations

• Study Contact: Name: Xiufeng Li, Ph.D.; Phone Number: 6126258258; Email: lixx1607@umn.edu

Study Locations

• United States
  • Minnesota
    • Minneapolis, Minnesota, United States, 55455
      • Recruiting
      • Center for Magnetic Resonance Research
      • Contact: Xiufeng Li, PhD; Phone Number: 612-625-8258; Email: lixx1607@umn.edu

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 80 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

Normal participants will be recruited for four age groups with the following age ranges: 21 - 35, 36 -50, 51 - 65 and 66 - 80 years. For each subject group, equal number of male and female subjects will be recruited.

Description

Inclusion Criteria:

1. English-speaking as primary language
2. No hearing loss or uncorrected vision

Exclusion Criteria:

1. Lacking capacity to consent
2. Having known history of cardiovascular diseases (e.g., clinical stroke)
3. Having acute and chronic obstructive pulmonary disease
4. Having known history of renal diseases (e.g., acute kidney injury)
5. Having known history of cognitive disorder or psychiatric illness
6. Having known history of chemical dependence (e.g., alcohol and narcotics)
7. Being treated with stimulant medications, anticonvulsants, antihypertensives or ß-adrenergic blockers

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Cross-Sectional

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Group 1; normal 21-35 years old participants	Other: MRI; Perform MRI studies
Group 2; normal 36-50 years old participants	Other: MRI; Perform MRI studies
Group 3; normal 51-65 years old participants	Other: MRI; Perform MRI studies
Group 4; normal 66- 80 years old participants	Other: Group 4; Perform MRI studies

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
MRI measured perfusion for each group	MRI measurements will be summarized for each group by using mean and standard deviation or standard error.	Baseline
MRI measured vascular reactivity for each group	MRI measurements will be summarized for each group by using mean and standard deviation or standard error.	Baseline
Cognitive performance for each group	The total cognitive performance scores will be summarized for each group by using mean and standard deviation or standard error.	Baseline

Collaborators and Investigators

• Sponsor: University of Minnesota
• Investigators: Principal Investigator: Xiufeng Li, Ph.D., University of Minnesota

Study record dates

Study Major Dates

• Study Start (Estimated): December 1, 2026
• Primary Completion (Estimated): December 31, 2030
• Study Completion (Estimated): December 31, 2032

Study Registration Dates

• First Submitted: June 15, 2016
• First Submitted That Met QC Criteria: July 8, 2016
• First Posted (Estimated): July 13, 2016

Study Record Updates

• Last Update Posted (Estimated): October 15, 2025
• Last Update Submitted That Met QC Criteria: October 13, 2025
• Last Verified: October 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 1603M85492

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No