Memory and Attention in Healthy Children (MASK)

Memory, Auditory and Visual Attention in Healthy Children: Neurophysiological and Electrophysiological Aspects

This project studies memory and attention in healthy children aged from 5 to 17 years. The processes investigated are short term memory (auditory and visual) and attention.

To characterize these processes involved in childhood, neuropsychological and neurophysiological assessments will be performed (using Electro-encephalography measures, behavioural responses and questionnaires).

Study Overview

• Status: Unknown
• Conditions: Healthy Volunteers
• Intervention / Treatment: Other: Experience 1 : Auditory and Visual Discrimination; Other: Experience 2 : Passive and Active Auditory Perception; Other: Experience 3 : Visual Attention Training; Other: Experience 4 : Attention and Distractibility; Other: Experience 5 : Sustained Visual Attention

• Study Type: Interventional
• Enrollment (Anticipated): 400
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Lyon, France, 69500
    • Recruiting
    • Hôpital Femme Mère Enfant
    • Contact: Julia JUNG, MD, PHD; Phone Number: +33 (0)4 27 85 60 53; Email: julien.jung@inserm.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 5 years to 17 years (Child)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Normal or corrected vision
• No neurological and psychiatric antecedent.
• No neuro-developmental disorder (dysphasia, dyslexia, dyspraxia, attention deficit disorder…)
• Motivation to participate to the study
• Signed parental informed consent authorizing their child to participate to the study

Exclusion Criteria:

• Children educated in a specialized institution.
• Subjects diagnosed with a neurological, psychiatric or neuro-developmental disorder
• Subjects with hearing loss
• Subjects with a visual impairment that cannot be corrected
• Subjects with an organic or chronic disease that can affect cognitive functions.
• Subjects who do not benefit from social security.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

Experimental: Healthy Children; Memory and Attention in healthy children will be assessed non-invasively through behavioral and electrophysiological measures while participants will perform passive or active computer task involving auditory and/or visual perception.

Other: Experience 1 : Auditory and Visual Discrimination; Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.; Other: Experience 2 : Passive and Active Auditory Perception; Neuropsychological tests consist in listening to sounds under 2 conditions, an active or a passive one, during which different auditory stimuli will be presented: frequent stimuli (standard) and rare stimuli (deviants). These two stimuli differ in some of their feature (height, duration, …). A third, very rare (novel) stimulus will also be used (the subject's first name). Responses will be provided using a response-button and feedback will be given at each response. EEG will be recorded all along to measure Neurophysiological signals.; Other: Experience 3 : Visual Attention Training; This experience aims at training visual attention through serious games. Children will play against an artificial intelligence and will focus their attention on one out of many possible targets (checkers, cards, boxes) presented on screen. Responses will be provided using a response-button, sometimes completed by an eye-tracking measure. Feedback will be given to the child after his response. EEG will be recorded all along to measure Neurophysiological signals.; Other: Experience 4 : Attention and Distractibility; Neuropsychological tests consist in listening to sounds preceded by a visual cue indicating (or not) in which ear the sounds will be played. The subject Child should detect the target sound (e.g. a dog barking). In some trials, a distracting distraction will be introduced between the visual cue and the target sound. Responses will be provided using a response-button. EEG will be recorded all along to measure Neurophysiological signals.; Other: Experience 5 : Sustained Visual Attention; Neuropsychological tests consist in watching visual stimuli presented in 3 blocks of 3 minutes each, with a break of one minute between each block. The child has to detect the presence of a red letter in a pattern made of four letters (the three other letters are black). Behavioral responses will be provided using a response-button. EEG will be recorded all along to measure Neurophysiological signals.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Neuropsychological tests: Proportion of accurate answers	2 months
Neuropsychological tests: reaction time of answers (seconds)	2 months
Neurophysiological tests: Event-related potentials in response to auditory and visual stimulations	2 months

Secondary Outcome Measures

Outcome Measure	Time Frame
Proportion of accurate answers according to age range of children	2 months
reaction time of answers (seconds) according to age range of children	2 months
Event-related potentials in response to auditory and visual stimulations according to age range of children	2 months

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon

Study record dates

Study Major Dates

• Study Start (Actual): October 6, 2016
• Primary Completion (Anticipated): October 6, 2020
• Study Completion (Anticipated): October 6, 2020

Study Registration Dates

• First Submitted: July 29, 2016
• First Submitted That Met QC Criteria: August 5, 2016
• First Posted (Estimate): August 8, 2016

Study Record Updates

• Last Update Posted (Actual): August 9, 2017
• Last Update Submitted That Met QC Criteria: August 8, 2017
• Last Verified: August 1, 2017

More Information

Terms related to this study

• Keywords: Child; Attention; EEG; Short-term memory; Aural Memory; Visual Memory
• Other Study ID Numbers: 69HCL15_0711

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No