Better Life by Nutrition During Adulthood (BELINDA)

Better Life by Nutrition During Adulthood : Identification of Factors Present in Adolescence Cardiovascular Risk in Young Adults

BELINDA is a follow'up of subjects included 10 years ago in HELENA study which was a cross-sectional study carried out from 2006 to 2007 in more than 3500 adolescents aged from 12.5 to 17.5 years old through 10 Europeans towns from 9 countries.

BELINDA main objective is to assess CV risk using PDAY score (Pathobiological Determinants of Atherosclerosis in Youth) during young adulthood (20 to 31 years) and analyze lifestyle risk factors from adolescence (12 to 18 years). This analyze may define new CV risk factors and risk population cluster.

Study Overview

• Status: Completed
• Conditions: Cardiovascular Risk Factor

Detailed Description

BELINDA subjects from Lille, Ghent , Zaragoza and Roma will be re-tested using a part of HELENA test battery and some new evaluation criteria.

• Study Type: Observational
• Enrollment (Actual): 72

Contacts and Locations

Study Locations

• France
  • Lille, France
    • CHRU,Hôpital Jeanne de Flandres

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 20 years to 35 years (Adult)
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

BELINDA is a follow'up of subjects included 10 years ago in HELENA study which was a cross-sectional study carried out from 2006 to 2007 in more than 3500 adolescents aged from 12.5 to 17.5 years old through 10 Europeans towns from 9 countries.

BELINDA will retest subjects from Lille and Ghent

Description

Inclusion Criteria:

• Women of men participating to HELENA study 2006-2007
• Aged from 20 to 35 years.
• Signed informed consent

Exclusion Criteria:

• Pregnant or lactating women

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
PDAY score (Pathobiological Determinants of Atherosclerosis in Youth)	PDAY score is a composite score which will be calculated using adult data including Gender, HDL non cholesterol, HDL cholesterol. Glucose level, Blood pressure, Tobacco consumption and BMI.	one day

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Diet Quality Index Score	data collected using HELENA-DIAT, an electronic dietary recall, data in DQI score unit. DQI score is ranking from 0 to 9 unit and is based on three basic principles for a healthy diet: quality; diversity; balance. Furthermore, the daily diet was divided into nine recommended food groups, namely (1) water, (2) bread and cereals, (3) grains and potatoes, (4) vegetables, (5) fruit, (6) milk products (7), cheese, (8) meat, fish, eggs and substitutes, and (9) fats and oils.	2 days
Ratio total energy intake	data collected using HELENA-DIAT, an electronic dietary recall, data in kcal/d, data for recommended total energy intake will be collected using national reference chart.	2 days
ratio of dietary n-6/n-3 polyunsaturated fatty acids (PUFA)	data collected using HELENA-DIAT, an electronic dietary recall, data in ratio calculated using a food composition data base. PUFA is expressed in mg/day daily intake.	2 days
consumption in dietary salt intake	data collected using HELENA-DIAT, an electronic dietary recall, data in mg/day daily intake calculated using a food composition data base.	2 days
Physical activity	data collected using a GT3X accelerometer data in daily counts/min	7 days
Endurance	data collected using Dr Leger Shuttle run test, data in VO2max ml/kg/min	1 day
Ratio waist-to-hip	data collected using anthropometric measurements, data in ratio. Data are expressed in centimeter	1 day
Fat mass	data collected using anthropometric measurements, data in % of fat mass, expressed in kg	1 day
Education level	data collected using a Socio-economic questionnaire, data in Education level 8 digits	1 day

Collaborators and Investigators

• Sponsor: University Hospital, Lille
• Investigators: Principal Investigator: Frédéric Gottrand, MD, PhD, University Hospital, Lille

Publications and helpful links

General Publications

• Morcel J, Beghin L, Michels N, De Ruyter T, Drumez E, Cailliau E, Polito A, Le Donne C, Barnaba L, Azzini E, De Henauw S, Miguel Berges ML, Cacau LT, Moreno LA, Gottrand F. Nutritional and physical fitness parameters in adolescence impact cardiovascular health in adulthood. Clin Nutr. 2024 Aug;43(8):1857-1864. doi: 10.1016/j.clnu.2024.06.022. Epub 2024 Jun 26.

Study record dates

Study Major Dates

• Study Start (Actual): February 23, 2017
• Primary Completion (Actual): March 25, 2022
• Study Completion (Actual): March 25, 2022

Study Registration Dates

• First Submitted: August 24, 2016
• First Submitted That Met QC Criteria: September 8, 2016
• First Posted (Estimated): September 14, 2016

Study Record Updates

• Last Update Posted (Estimated): December 23, 2025
• Last Update Submitted That Met QC Criteria: December 16, 2025
• Last Verified: September 1, 2022

More Information

Terms related to this study

• Keywords: cardiovascular risk; young adulthood
• Other Study ID Numbers: 2015_24; 2016-A00386-45 (Other Identifier: ID-RCB number, ANSM)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No