- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03062904
Search of a Paradoxical Fall in Maximum Expiratory Flow After Bronchodilation in Healthy Subjects (VACUVOL)
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
There exists a physiological limitation of the expiratory flows because of the physical properties of the bronchial tree (flexible bronchial walls in a complex architecture subjected to variations of pressure and volume). For a given lung, in a given state, for each pulmonary volume there is a corresponding Maximum Expiratory Flow (MEF). In healthy subject, the bronchial smooth muscles have a basal tonicity which is not negligible. If the tonicity is increased, this generally leads to a reduction in MEF. If it is decreased, MEF rather tends to increase, there are healthy individuals for whom the inhibition of the contraction of the bronchial smooth muscles by inhalation of bronchodilatator leads to a reduction in the MEF: this is called "paradoxical effect". When this reduction exists, it appears it occurs at low pulmonary volumes (approximately 50% for a volume of less than 25% of the CV). Under this circumstance, it seems that the basal tonicity of the bronchial smooth muscles would fight against the expiratory collapse of the bronchi, and this would happen especially for distal bronchi, for low pulmonary volume and for forceful expiration. The existence of such a phenomenon would be in favour of a "stiffening" role of the bronchial smooth muscles. The bronchial smooth muscles would not be only harmful cells causing of the asthma attacks.
Primary end-point:
The aim of this study is to evaluate the occurrence or increase of the Expiratory Flow Limitation (EFL) under either Negative Expiratory Pressure (NEP) or submaximal gentle forced expiratory manoeuvres (partial flow-volume loops at tidal volume) after bronchodilation in certain healthy men breathing at low pulmonary volumes (by applying a chest wall strapping).
Secondary end-point:
The secondary objectives are
to evaluate the effect of the fall of the tonicity of the bronchial smooth muscles (normal and constrained pulmonary volumes) on the following criteria/variables:
- the closing volume: we would expect an increase of it.
- modifications of forced flow-volume loop; we would expect a reduction in the MEF at low lung volumes.
- some modifications of the Pulmonary Function Test (PFT); we would expect an absence of significant difference in certain pulmonary volumes (Vital Capacity - VC, Total Lung Capacity -TLC,…), perhaps with a reduction in the Inspiratory Capacity (IC), an increase in airways resistances by high frequency oscillation
- Validation of the digital model of expiration of Florens-Filoche: towards a tool of assistance to the interpretation of the PFT.
During the various experimental sessions, we will record a certain "number" of variables that will be necessary to "feed" the final model of Florens-Filoche, such as:
- Oesophageal Pressure, Mouth Pressure: continuously. Static oesophageal pressure at:
- Residual Volume -RV, TLC, VC
- flows and pulmonary volumes continuously.
This study will attempt to develop a tool to assist in the interpretation of the PFT:
- earlier disease detection (of the bronchial smooth muscles),
- better follow-up of obstructive pathologies, their response to the treatment,
- simplification of the diagnosis of asthma,
- automation of interpretation…
Study Design:
The study includes 3 visits, as follows:
Visit 0:
Anthropometric characteristics Medical screening and eligibility criteria Chest X-ray ECG Blood pressure Pulse oximetry, heart rate PFT
Visit 1:
The first visit (V1) will last 3h and 30 minutes roughly and will consist of:
- PFT: spirometry, maximal flow-volume loops (MFVL), in sitting position.
- Closing Volume and airways resistances in sitting position.
- Insertion of a small oesophageal catheter for continuous monitoring of the oesophageal pressure and measurement of static pressure at some volumes
- Thoraco-abdominal (chest wall) strapping
- Measures of slow VC and MFVL in lying position
- Either NEP in lying position or submaximal gentle forced expiratory manoeuvres (partial flow-volume loops at tidal volume)
- Removal of the thoraco-abdominal (chest wall) strapping
- Test of Bronchodilatation (combined Salbutamol 200μg and Ipratropium bromure 80μg; 2 inhalations): wait 30 min and then
- Thoraco-abdominal (chest wall) strapping
- Either NEP or submaximal gentle forced expiratory manoeuvres (partial flow-volume loops at tidal volume)
- Measures of slow VC and MFVL in lying position
- Removal of the thoraco-abdominal (chest wall) strapping
- Measures of slow VC and MFVL in sitting position
- Removal of the small oesophageal catheter
- Closing Volume and airways resistances in sitting position
Each measurement will be repeated at least 3 times, until at least 2 reproducible measurements are obtained.
Visit 2:
The second meeting (V2) will be proposed only to participants who will present with a reduction in some of their MEF at the time of V1 of the protocol. It will consist of Methacholine Challenge Test. The duration of this test is approximately 1 hour.
Number of Subjects to be included: 65 healthy subjects under 35y are necessary find at lest 6 subjects presenting with a "paradoxal effect".
Duration of the study: two years
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: Pierantonio Laveneziana, MCUPH
- Phone Number: 00 33 (0) 1 42 17 85 84
- Email: pierantonio.laveneziana@psl.aphp.fr
Study Contact Backup
- Name: Claudia Llontop Guzman, PH
- Phone Number: 00 33 (0) 1 42 17 85 13
- Email: claudia.llontop@psl.aphp.fr
Study Locations
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-
-
Paris, France, 75013
- Recruiting
- Pitie-Salpêtrière Hospital
-
Contact:
- Eric DASQUE, Nurse
- Phone Number: 00 33 (0) 1 42 17 85 34
- Email: eric.dasque@psl.aphp.fr
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
All the volunteers will:
- be between 18 and 35 years/old
- be male (because of binding thoracic, more difficult to realize and more uncomfortable in the female subjects)
- have to understand French
- have to be affiliated to the social security
- have to be "non smokers, or having never smoked"
- have to have read and have understood the information record
- have to have signed the informed consent
- have to not to be involved in a former scientific study.
- abnormal PFT (at least one value below the lower limit of normal)
- Abnormal chest radiography
- Abnormal ECG
Exclusion Criteria:
- Chronic pathology
- Long-standing treatments, recent vaccination (< 3 weeks), recent bronchitis (< 3 weeks)
- Cardio-respiratory diseases, in particular: asthma, COPD, previous pneumothorax, hemoptyses, acute coronary syndrome, uncontrolled and/or untreated cardiac arrhythmia, bradycardia (<55bpm), arterial hypertension (diastolic>95mmHg, systolic>150mmHg),
- Current abdominal disease (clinical or known hepatomegaly, irritable bowel syndrome, etc…), gastro-oesophageal reflux
- BMI < 18 and > 26
- Disorder of coagulation (and anticoagulant treatment), frequent epistaxis
- Porphyrae
- Epilepsy, Cerebrovascular accident (stroke or transient ischemic attack) < 3 months
- Severe hepatic Insufficiency
- Glaucoma
- Benign Prostatic Hypertrophy
- Allergy: latex, lidocaine, salbutamol, ipratropium or parasympathomimetic agents
- Current allergic rhino-conjunctivitis
- History of previous oedema of Quincke or anaphylactic shock
- Aneurism of the aorta, cerebral aneurism or another arterial aneurism
- Myasthenia
- Thyroid disorders
- Protected underage child and adults
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Diagnostic
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: drug
|
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Occurrence or increase of the Expiratory Flow Limitation (EFL) under either Negative Expiratory Pressure (NEP) or submaximal gentle forced expiratory manoeuvres (partial flow-volume loops at tidal volume)
Time Frame: After bronchodilation, up to 2 hours
|
The aim of this study is to evaluate the occurrence or increase of the Expiratory Flow Limitation (EFL) under either Negative Expiratory Pressure (NEP) or submaximal gentle forced expiratory manoeuvres (partial flow-volume loops at tidal volume) after bronchodilation in certain healthy men breathing at low pulmonary volumes (by applying a chest wall strapping).
|
After bronchodilation, up to 2 hours
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Evaluation of the effect of the fall of the tonicity of the bronchial smooth muscles (normal and constrained pulmonary volumes) on the closing volume
Time Frame: after bronchodilation while breathing at low pulmonary volumes (by applying a chest wall strapping), up to 2 hours
|
after bronchodilation while breathing at low pulmonary volumes (by applying a chest wall strapping), up to 2 hours
|
Evaluation of the effect of the fall of the tonicity of the bronchial smooth muscles (normal and constrained pulmonary volumes) on the modifications of forced flow-volume loop
Time Frame: after bronchodilation while breathing at low pulmonary volumes (by applying a chest wall strapping), up to 2 hours
|
after bronchodilation while breathing at low pulmonary volumes (by applying a chest wall strapping), up to 2 hours
|
Evaluation of the effect of the fall of the tonicity of the bronchial smooth muscles (normal and constrained pulmonary volumes) on the inspiratory capacity airways resistances
Time Frame: after bronchodilation while breathing at low pulmonary volumes (by applying a chest wall strapping), up to 2 hours
|
after bronchodilation while breathing at low pulmonary volumes (by applying a chest wall strapping), up to 2 hours
|
Collaborators and Investigators
Investigators
- Principal Investigator: Pierantonio Laveneziana, MCUPH, Assistance Publique - Hôpitaux de Paris
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
- Physiological Effects of Drugs
- Neurotransmitter Agents
- Molecular Mechanisms of Pharmacological Action
- Autonomic Agents
- Peripheral Nervous System Agents
- Cholinergic Agents
- Cholinergic Agonists
- Anti-Asthmatic Agents
- Respiratory System Agents
- Miotics
- Parasympathomimetics
- Bronchoconstrictor Agents
- Muscarinic Agonists
- Methacholine Chloride
- Bronchodilator Agents
Other Study ID Numbers
- P120301
- 2012-A01643-40 (Other Identifier: IDRCB)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
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