SLeep and IMagery Correlates (SOMMEIL-IMAGERIE)

Neurophysiological Correlates of Sleep Motor Consolidation Following Motor Imagery Practice

This study is designed to determine the neural networks underlying the sleep-related motor consolidation process following motor imagery practice. While beneficial effects of sleep are expected for sequential movement but not for adaptation motor tasks, the corresponding neuroanatomical correlates have not yet been investigated when participants acquired the motor tasks through mental practice. Data should substantially promote how designing motor imagery interventions targeting (re)learning and/or motor recovery in patients suffering from motor disorders.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Other: Imagery and Sleep questionnaires; Other: MEG recordings (pre-test); Other: Practice session; Other: MEG recordings (Post-test); Other: MRI

• Study Type: Interventional
• Enrollment (Actual): 51
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Bron, France, 69500
    • CH le Vinatier

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 40 years (Adult)
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Healthy right-handed persons without neurologic disease
• Persons having signed informed consent for a neuroimagery study

Exclusion Criteria:

• Persons under curatorship or any administrative/judicial measure
• Participants refusing to be informed of the results of the experiment
• Pregnant women
• Participants with contraindications to the MEG examination: head size, presence of a neurostimulator, steel pivot for the root canal, metallic fragments, ear implants, metal screws in the body or mouth.
• Persons using a pacemaker, insulin pump, or working regularly with iron filings
• Claustrophobic persons

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: NightPP; Participants of the NightPP will be subjected to one MRI session and two MEG recording sessions: the first one before a physical practice session of the two motor tasks investigated in the study, and second MEG session right after practice.	Other: Imagery and Sleep questionnaires; Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep; Other: MEG recordings (pre-test); Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.; Other: Practice session; Participants of the Day group perform a block of motor imagery practice of the two motor tasks.; Other: MEG recordings (Post-test); Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test); Other: MRI; The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.
Experimental: NightMI; Participants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice.	Other: Imagery and Sleep questionnaires; Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep; Other: MEG recordings (pre-test); Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.; Other: Practice session; Participants of the Day group perform a block of motor imagery practice of the two motor tasks.; Other: MEG recordings (Post-test); Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test); Other: MRI; The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.
Experimental: NightCtrl; Participants of the NightCtrl will be subjected to one MRI session and two MEG recording sessions: the first one before a mental rotation practice session, a second MEG session right after practice,and second MEG session right after practice.	Other: Imagery and Sleep questionnaires; Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep; Other: MEG recordings (pre-test); Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.; Other: Practice session; Participants of the Day group perform a block of motor imagery practice of the two motor tasks.; Other: MEG recordings (Post-test); Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test); Other: MRI; The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.
Experimental: Day; Participants of the NightMI will be subjected to one MRI session and two MEG recording sessions: the first one before a motor imagery practice session of the two motor tasks investigated in the study, and second MEG session right after practice.	Other: Imagery and Sleep questionnaires; Participants complete a motor imagery questionnaire to assess their ability to form vivid mental images, as well as sleep questionnaires to control the quality of their sleep; Other: MEG recordings (pre-test); Participants of the Day group perform two motor tasks (a finger sequential motor task and an adaptation motor task using a trackball) in the MEG, during a pre-test (Day 1 - 9h). Task 1: Participants perform an 8-digit motor sequential task where each finger (except the thumb) is used twice. Performance is assessed by using a 4-keys keyboard. Participants are required to keep their fingers on the keys to minimize amplitude are instructed to tap the sequence as few errors as possible Task 2: Participants perform a motor adaptation task requiring scrolling a trackball to superimpose a geometric shape on another one, strictly similar but presented from another angle, as fast as possible.; Other: Practice session; Participants of the Day group perform a block of motor imagery practice of the two motor tasks.; Other: MEG recordings (Post-test); Participants perform the two motor tasks in the MEG (post-test, strictly similar to the pre-test); Other: MRI; The registration of the brain anatomy of each participant will be done by MRI 3D / T the week before the first experimental session.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Evidence of MEG correlates of sleep motor consolidation (day 1)	The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Evidence of MEG correlates of sleep motor consolidation (day 2)	The investigator will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time needed to complete the motor tasks (day 1)	The investigators will measure the time needed to complete the motor tasks needed to complete each motor task (finger sequential tasks OR motor adaptation task).	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Evidence of MEG correlates of sleep motor consolidation	The investigators will use Single Aperture Magnetometry, i.e. a minimum variance beamformer mapping the spatial distribution of event-related desynchronizations and synchronizations within a predetermined frequency domain (Beta oscillations 15-35 Hz). The time course of MEG Beta power will be considered, and Granger causal connectivity analyses will be performed to investigate relationships between cortical motor regions.	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Accuracy of the motor tasks	The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).	Day 1 at 19h00 [post-training] (Groups 1, 2 and 3) OR Day 1 at 9h00 [post-training] (Group 4)
Time needed to complete the motor tasks	The investigators will measure the time needed to complete each motor task (finger sequential tasks OR motor adaptation task).	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)
Accuracy of the motor tasks 2	The investigators will measure the number of errors and correct trials for each motor task (finger sequential tasks OR motor adaptation task).	Day 2 at 9h00 [Retention test] (Groups 1, 2 and 3) OR Day 1 at 19h00 [Retention test] (Group 4)

Collaborators and Investigators

• Sponsor: Hospices Civils de Lyon
• Investigators: Principal Investigator: Alain Nicolas, MD, CH le Vinatier

Publications and helpful links

General Publications

• Di Rienzo F, Debarnot U, Daligault S, Delpuech C, Doyon J, Guillot A. Brain plasticity underlying sleep-dependent motor consolidation after motor imagery. Cereb Cortex. 2023 Nov 27;33(23):11431-11445. doi: 10.1093/cercor/bhad379.

Study record dates

Study Major Dates

• Study Start (Actual): December 9, 2015
• Primary Completion (Actual): December 9, 2017
• Study Completion (Actual): July 4, 2018

Study Registration Dates

• First Submitted: March 10, 2017
• First Submitted That Met QC Criteria: April 21, 2017
• First Posted (Actual): April 26, 2017

Study Record Updates

• Last Update Posted (Estimated): September 15, 2025
• Last Update Submitted That Met QC Criteria: September 9, 2025
• Last Verified: September 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 69HCL16_0676

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No