Long-Term Outcome Following Regenerative Periodontal Treatment of Intrabony Defects

Long-Term Outcome Following Regenerative Periodontal Treatment of Intrabony Defects: A Retrospective Study at Mahidol University

Many years ago, periodontal regenerative treatment has been done in Periodontics and Oral Medicine Clinic, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. However, there is still lacking of study about long-term result of periodontal regenerative treatment of intrabony defects.

Study Overview

• Status: Completed
• Conditions: Regenerative Periodontal Treatment
• Intervention / Treatment: Procedure: regeneration treated teeth loss; Procedure: regenerated treated teeth with clinical attachment loss

Detailed Description

Beside, in the present, some materials for periodontal regenerative treatment are still expensive. Periodontists and patients have to plan together based on not only rationale of treatment but also cost and effectiveness. Thus the long-term result of treatment could be useful for the decision making.

• Study Type: Observational
• Enrollment (Actual): 89

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The patients who received regenerative periodontal therapy of the intrabony defects by post-graduate students at the Periodontics and Oral Medicine Clinic, Faculty of Dentistry, Mahidol University, Thailand and were placed in the Recall Patient Bank from 2000 to 2014.

Description

Inclusion Criteria:

• Patients who received regenerative therapy of the intrabony defects
• Patients who had the record of re-evaluation at 1 year post-surgery

Exclusion Criteria:

• Patients who received regenerative therapy involving the furcation area
• Patients who received non-periodontal regenerative therapy
• Patients who received endodontic regeneration
• Patients who had an incomplete periodontal data recording

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
tooth loss; regeneration treated teeth loss	Procedure: regeneration treated teeth loss; number of regeneration treated teeth loss
clinical attachment loss ≥ 2 mm; regenerated treated teeth with clinical attachment loss ≥ 2 mm	Procedure: regenerated treated teeth with clinical attachment loss; regenerated treated teeth with clinical attachment loss ≥ 2 mm
clinical attachment loss loss < 2 mm; regenerated treated teeth with clinical attachment loss < 2 mm	Procedure: regenerated treated teeth with clinical attachment loss; regenerated treated teeth with clinical attachment loss ≥ 2 mm

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Percentage of regenerative-treated tooth loss after periodontal regeneration	Percentage of regenerative-treated tooth loss since 1 year after periodontal regeneration until last visit of supportive periodontal treatment	1 year
Percentage of regenerative-treated sites with clinical attachment loss ≥ 2 mm	Percentage of regenerative-treated sites with clinical attachment loss ≥ 2 mm since 1 year after periodontal regeneration until last visit of supportive periodontal treatment	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Variables (patient and tooth characteristics) that associated with tooth loss or clinical attachment loss	Patient variables and tooth characteristics associated with regenerative-treated tooth loss or sites with clinical attachment loss ≥ 2 mm from any supportive periodontal treatment visits (the last supportive periodontal treatment visit) compared to baseline or 1-year after surgery.	1 year

Collaborators and Investigators

• Sponsor: Mahidol University

Study record dates

Study Major Dates

• Study Start: January 1, 2015
• Primary Completion (Actual): April 1, 2015
• Study Completion (Actual): April 1, 2015

Study Registration Dates

• First Submitted: November 13, 2015
• First Submitted That Met QC Criteria: May 5, 2017
• First Posted (Actual): May 9, 2017

Study Record Updates

• Last Update Posted (Actual): May 9, 2017
• Last Update Submitted That Met QC Criteria: May 5, 2017
• Last Verified: May 1, 2017

More Information

Terms related to this study

• Keywords: periodontal regeneration; intrabony defect
• Other Study ID Numbers: 2014/DT105

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO