Sero-epidemiology of Priority Arboviruses in French Guiana (EPI-ARBO)

Dengue is an important public health problem despite the efforts of local health authorities to mitigate the impact of epidemics and the epidemiology of dengue evolved from an endemo-epidemic to a hyper-endemic state. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories including French Guiana. Rapidly, more than 16,000 suspected local Health authorities had reported cases. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil. The emergence of Zika virus in South America led to a rapid spread throughout South and Central America, reaching French Guiana in December 2015. With the increasing frequency of epidemics related to arbovirus and the resulting health, social, and economic impacts of dengue, the surveillance of arbovirus have become social, political, and public health challenges that require specific and non-available immune status information.

Study Overview

• Status: Completed
• Conditions: Arbovirus Infections
• Intervention / Treatment: Other: Human Biological samples

Detailed Description

French Guiana is a 250,000 inhabitant's French overseas department located in South America, the epidemiology of arboviruses has recently evolved and marked by important outbreaks.

Dengue remains an important public health problem despite the efforts of local health authorities to mitigate the impact of epidemics and the epidemiology of dengue evolved from an endemo-epidemic to a hyper-endemic state. In late 2013, the first local transmission of chikungunya virus in the Americas was identified in Caribbean countries and territories including French Guiana. Rapidly, more than 16,000 suspected local Health authorities had reported cases. In May 2015, the Pan American Health Organization (PAHO) issued an alert regarding the first confirmed Zika virus infections in Brazil. The emergence of Zika virus in South America led to a rapid spread throughout South and Central America, reaching French Guiana in December 2015. With the increasing frequency of epidemics related to arbovirus and the resulting health, social, and economic impacts of dengue, the surveillance of arbovirus have become social, political, and public health challenges that require specific and non-available immune status information.

• Study Type: Interventional
• Enrollment (Actual): 2697
• Phase: Not Applicable

Contacts and Locations

Study Locations

• France
  • Cayenne, France, 97306
    • Institut Pasteur de la Guyane

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 2 years to 75 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Guiana resident for at least 6 months and present during the entire study period
• Age between 2 and 75 years old

Exclusion Criteria:

• Subject under guardianship or deprived of liberty by judicial decision
• Subject with any pathology or health problem not compatible with blood sampling

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Guiana population; Human Biological samples from Guiana population : Two serum tubes of blood will be collected	Other: Human Biological samples; Blood sample

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Dengue, chikungunya, zika Antibodies detection by multiplex serologic tests	Description of the virological status of individuals by Mutiplex detection of antibodies directed against dengue, chikungunya and zika arboviruses.	2 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Seroprevalence by area and age	Estimatation of the frequency of Dengue, Chikungunya and zika infections among the general population of French Guiana by geographical area and by age class	2 years

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Dengue infections proportion	Proportion of dengue primary and multiple infections in Guiana population.	2 years

Collaborators and Investigators

• Sponsor: Institut Pasteur
• Investigators: Principal Investigator: Claude Flamand, Institut Pasteur de la Guyane

Study record dates

Study Major Dates

• Study Start (Actual): June 9, 2017
• Primary Completion (Actual): November 21, 2017
• Study Completion (Actual): June 30, 2020

Study Registration Dates

• First Submitted: June 16, 2017
• First Submitted That Met QC Criteria: July 5, 2017
• First Posted (Actual): July 6, 2017

Study Record Updates

• Last Update Posted (Actual): September 14, 2020
• Last Update Submitted That Met QC Criteria: September 11, 2020
• Last Verified: September 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Virus Diseases; Infections; Vector Borne Diseases; Arbovirus Infections
• Other Study ID Numbers: 2016-073

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No