Chronic Effects of Fats on Satiety & Energy Needs

August 1, 2018 updated by: USDA Grand Forks Human Nutrition Research Center

Chronic Effects of Fats on Satiety and Energy Expenditure

The purpose of this study is to evaluate the effect of dietary fat on satiety (the experience of fullness between one meal and the next) and energy metabolism over an extended period of time (chronic effects). How dietary fat sources affect satiety, appetite and energy use is unclear. The investigators will use a controlled setting for the studies. They want to know if the source of dietary fat alters satiety, satiety hormones, and energy expenditure responses after consuming different diets.

Study Overview

Status

Terminated

Conditions

Intervention / Treatment

Detailed Description

This work will address the interaction of obesity and dietary fatty acids in regulating satiety and energy metabolism. The primary objective is to determine the effects of chronic intake of dietary fatty acids of varied saturation and chain length on satiety, thermogenesis and energy utilization in healthy individuals. The investigators hypothesize that unsaturated fatty acids will 1) increase satiety and 2) increase energy metabolism and that 3) the fatty acid binding protein polymorphisms are associated with reduced energy expenditure in response to dietary fat intake.

Study Type

Interventional

Enrollment (Actual)

1

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • North Dakota
      • Grand Forks, North Dakota, United States, 58203
        • USDA Grand Forks Human Nutrition Research Center

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 55 years (ADULT)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • body mass index between 25.0-34.9 kg/m2
  • free of major diagnosed, untreated medical conditions
  • non-smoking or use of other tobacco products, including e-cigarettes
  • not taking steroid-based medications
  • not planning to or currently attempting to gain or lose weight
  • willing to comply with study demands
  • low intake of long chain omega-3 fatty acids (<0.10 g/d) or willing to reduce intake for 6 weeks prior to starting the study

Exclusion Criteria:

  • diagnosed eating disorders
  • diabetes (blood sugar ≥ 126 mg/dl)
  • hypertension (systolic > 160 mmHg or diastolic > 100 mmHg)
  • diagnosed cardiovascular, pulmonary, skeletal and metabolic diseases
  • currently pregnant or planning to become pregnant, or lactating
  • taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: OTHER
  • Allocation: RANDOMIZED
  • Interventional Model: CROSSOVER
  • Masking: QUADRUPLE

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
OTHER: Saturated Fat/SFA
30 grams saturated fat (SFA) in the form of heavy whipping cream will be provided to subject in a mixed meal shake
Other: SFA
High saturated fatty acid/SFA oil source
OTHER: Monounsaturated Fat/MUFA
30 grams monounsaturated fat (MUFA) in the form of olive oil will be provided to subject in a mixed meal shake
Other: MUFA
High monounsaturated fatty acid/MUFA oil source
OTHER: Polyunsaturated Fat Linoleic/PUFA
30 grams high linoleic polyunsaturated fat (PUFA) in the form of high linoleic sunflower oil will be provided to subject in a mixed meal shake
Other: PUFA
High polyunsaturated fatty acid (linoleic)/PUFA oil source
OTHER: Polyunsaturated Fat Omega-3/LCn3
30 grams high omega-3 polyunsaturated fat (LCn3) in the form of fish oil will be provided to subject in a mixed meal shake
Other: LCn3
High polyunsaturated fatty acid (omega-3)/LCn3 oil source

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Acute effect of fat intake on energy expenditure as determined by metabolic rate
Time Frame: Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours
Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

USDA Grand Forks Human Nutrition Research Center

Investigators

  • Principal Investigator: Susan Raatz, PhD, USDA Grand Forks Human Nutrition Research Center

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (ACTUAL)

October 3, 2017

Primary Completion (ACTUAL)

May 24, 2018

Study Completion (ACTUAL)

May 24, 2018

Study Registration Dates

First Submitted

July 28, 2017

First Submitted That Met QC Criteria

July 28, 2017

First Posted (ACTUAL)

August 1, 2017

Study Record Updates

Last Update Posted (ACTUAL)

August 3, 2018

Last Update Submitted That Met QC Criteria

August 1, 2018

Last Verified

August 1, 2018

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • GFHNRC509

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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