- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03262987
Color Doppler U/S vs MSCT Venography in May-Thurner Syndrome (USvsCTV)
Color Doppler U/S vs MSCT Venography in the Diagnosis of May-Thurner Syndrome
May-Thurner syndrome is the result of compression of the left common iliac vein between the right common iliac artery and overlying vertebrae.
In This Study , We will detect the role of color doppler US in the diagnosis of May-Thurner Syndrome in comparison to Direct CT Venography
Study Overview
Status
Conditions
Detailed Description
May-Thurner syndrome (MTS) is a venous compression syndrome in which the left common iliac vein is compressed between the lower lumbar spine and the right common iliac artery. While asymptomatic compression is very common, the process can lead to morbidity in selected individuals, most commonly deep venous thrombosis (DVT) and the sequelae thereof. Radiologists must recognize the diagnosis because of the unique management, which differs from DVT without iliac vein compression.
The most common clinical presentation is unilateral leg swelling due to acute DVT. It can also present as chronic venous insufficiency or chronic thrombosis with symptoms of venous hypertension and venous stasis namely claudication, pain, swelling, varicose veins and / or ulceration.
Conventional invasive catheter venography remains the gold standard for diagnosis,but the decision to undertake invasive venography should be made only after reviewing all available clinical data and alternative, less invasive imaging options have been exhausted.
When visualization of the common iliac veins is possible, MTS may be diagnosed with transabdominal color Doppler U/S.
MDCT with IV contrast is a fast, widely available examination for the diagnosis of MTS and accompanying complications .
Magnetic resonance imaging (MRI) with MR venography is an attractive modality for the diagnosis, However, MRI is expensive, time consuming, has more limited availability than computed tomography (CT) and ultrasound, and may be impossible in select patients.
Study Type
Enrollment (Anticipated)
Contacts and Locations
Study Contact
- Name: Omar Mokhtar, M.B.B.CH
- Phone Number: +201094584576
- Email: ogamalm2217@gmail.com
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- advanced chronic venous insufficiency submitted to clinical treatment for at least 1 year with no response.
- Subject must be > 18 and < 80 years of age.
- informed consent document before the planned procedure.
- On duplex ultrasound: patent common femoral vein, and patent deep femoral vein, and/or femoral vein of the study leg.
Exclusion Criteria:
- Previous venous stent implantation involving the study leg or inferior vena cava
- Previous venovenous bypass surgery involving the study leg
- Known reaction or sensitivity to iodinated contrast that cannot be managed with premedication.
- Subjects who are pregnant (women of childbearing potential must have a negative pregnancy test within 7 days prior to enrollment).
- Acute deep venous thrombosis involving either leg.
- Known history of chronic total occlusion of the common femoral vein of the study leg.
- Venous compression caused by tumor encasement.
- Venous outflow obstruction caused by tumor thrombus.
- Elevated baseline blood creatinine (value greater than the upper limit of the normal range).
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Color Doppler U/S Vs MSCT Venography in the diagnosis of May-Thurner Syndrome
Time Frame: 1 year
|
Determine the sensitivity, specificity and accuracy of non invasive color doppler ultrasound, using direct and indirect ultrasonographic signs, in the diagnosis of May-Thurner Syndrome , considering direct CT Venography as the gold standard for this diagnosis.
|
1 year
|
Collaborators and Investigators
Sponsor
Investigators
- Study Chair: Mohamed Koraim, Ass. Prof., Assiut university, Egypt
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- May-Thurner Syndrome
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on May-Thurner Syndrome
-
Maastricht University Medical CenterUnknown
-
Imperial College LondonRecruitingMay-Thurner SyndromeUnited Kingdom
-
University Hospital of LimerickNot yet recruiting
-
Pirogov Russian National Research Medical UniversityCompletedMay-Thurner Syndrome | Pelvic Congestive Syndrome | Pelvic Venous DisordersRussian Federation
-
Assiut UniversityUnknown
-
Instituto Dante Pazzanese de CardiologiaFundação de Amparo à Pesquisa do Estado de São PauloCompletedMay-Thurner Syndrome | Iliac Vein Obstruction | Cockett SyndromeBrazil
-
Shanghai Zhongshan HospitalUnknownIliac Vein Compression SyndromeChina
-
Fabio H RossiFundação de Amparo à Pesquisa do Estado de São Paulo; Instituto Dante Pazzanese...UnknownVascular Ultrasound Versus Intravascular Ultrasound for Diagnosing Iliac Vein Obstruction (USG-DIVO)May-Thurner Syndrome | Iliac Vein Obstruction | Cockett SyndromeBrazil
-
Optimed Medizinische Instrumente GmbHCompletedPost-thrombotic Syndrome | Iliac Vein Compression SyndromeSwitzerland, Austria, Germany, Netherlands
-
Maastricht University Medical CenterCompletedMay-Thurner Syndrome | Post-thrombotic SyndromeNetherlands