The Effect of Different Drugs in the Prevention of Tooth Sensitivity Caused by Tooth Bleaching Treatment. (NSAIDs)

Combination of Two Analgesics Does Not Avoid Bleaching-induced Tooth Sensitivity: a Randomized, Triple-blind Clinical Trial

Background: The administration of the intra-oral drugs was not capable of reducing this side effect, maybe the use of two analgesics may to present better analgesic effect to avoid the bleaching-induced tooth sensitivity (TS). Methods: A triple-blind, parallel-randomized clinical trial was conducted with 114 health patients who received either a placebo or an association of ketorolac tromethamine/acetaminophen. The first doses of two analgesic (Acetaminophen 750 mg/ Ketorolac Tromethamine 10 mg) or placebo was administered 1 h before the in-office bleaching (35% hydrogen peroxide), and extra doses were administered every 8 h for 48 h. The TS was recorded using 0-10 visual analog scale and a 0-4 numeric rating scale in different periods: during bleaching and from 1 h up to 6h, from 12 h up to 18h, from 18h up to 24 h, from 24h up to 48 h post-bleaching. The color was measured before and one month after dental bleaching with a visual shade guide Vita Classical, Vita Bleachedguide 3D-Master and spectrophotometer Vita Easyshade (Vita Zahnfabrik). The absolute risk of TS was evaluated by Fisher's exact test. Data of TS intensity with NRS scale of the two groups were compared with Mann-Whitney and Friedman tests, while data from the VAS scale were evaluated by two-way repeated measures ANOVA and Tukey's test for pairwise comparison. The color changes between groups were compared using a Student t-test (α = 0.05).

Study Overview

• Status: Completed
• Conditions: Hydrogen Peroxide Allergy
• Intervention / Treatment: Drug: acetam/ketoro tromet group; Drug: Placebo group

Detailed Description

Trial design, settings and locations of data collection This was a randomized, parallel, placebo-controlled, triple-mask clinical trial, in which the patient, operator and evaluator were masked to the group assignment. A third researcher, not involved in the evaluation process, was responsible for the randomization process, and delivery and guidance on the administration of the drugs. This study was performed from 05/11/2017 up to 01/12/2018 in the city of Cascavel (Paraná, Brazil). All bleaching procedures were carried out within the Clinics of the Dental School of the State University of Oeste do Paraná (Cascavel, Paraná, Brazil).

Sample size calculation The primary outcome of this study was the absolute risk of TS. The absolute risk of TS was reported to be approximately 87% (Tay et al. 2009, De Paula et al. 2013) for the bleaching product Whiteness HP Maxx (FGM, Prod. Odont. Ltda, Joinville, SC, Brazil). Thus, a minimum sample size of 114 patients was required to have a 90% chance of detecting, as significant at the two-sided 5% level, a decrease in the primary outcome measure from 87% in the control group to 60% in the experimental group (which represent a difference of 31% in the absolute risk of TS).

Random sequence generation and allocation concealment. The investigator used blocked randomization (block sizes of 2 and 4) with an equal allocation ratio. The randomization process was performed by software freely available on the internet (www.sealedenvelope.com). Opaque and sealed envelopes containing the identification of the groups were prepared by third party, not involved in the study intervention. This third researcher, not involved in the evaluation process, was responsible for the randomization process, delivery and guidance on the administration of the drugs. A single random sequence was performed for both centers.

Study intervention Patients were divided into acetaminophen/ketorolac tromethamine and placebo groups. All patients received the same bleaching treatment, which was performed by four operators in the Dental School. One hour before in-office bleaching patients received either the acetaminophen 750 mg (Paracetamol 750 mg, Bioativa compounding pharmacy, Cascavel, PR, Brasil) and ketorolac tromethamine oral 10 mg (Toragesic® 10 mg, EMS Sigma Farma, Hortolândia, SP, Brasil) or placebo, for both medicines in identical tablets or capsules. The operator administered the first dose of drug 1 h before the protocol, and extra doses were administered every 8 h for 48 h to keep a safe maximum daily dosage of 4000 mg of acetaminophen and 40 mg of ketorolac tromethamine.

The tablets of Toragesic® and Paracetamol were removed them from their original packaging and inserted them whole into new vials made especially for this research. the investigator stored the capsules in individual vials containing 6 capsules of Paracetamol and 6 capsules of Toragesic® required for each bleaching session. The placebo tablets for Paracetamol contained starch lactose free (Bioativa compounding pharmacy, Cascavel, PR, Brasil) and the placebo capsules for Toragesic® contained base past, lactose free (Oro-tab®, Bioativa compounding pharmacy, Cascavel, PR, Brasil) and One hour before starting the bleaching application, the masked researcher responsible for drug administration gave the first dose to the patient. Then, the investigators isolated the gingival tissue of the teeth to be bleached using a light-cured resin dam (Top Dam, FGM Dental Products), and each tooth was light-cured for 10 s (Radii-cal, SDI, Victoria, Australia). After placement of a lip retractor (Arcflex, FGM), the researcher used the 35% hydrogen peroxide gel (Whiteness HP Automixx, FGM) in a single 50-minute application for both groups in accordance with the manufacturer's directions. Two bleaching sessions were performed 1 week apart. All participants were instructed to brush their teeth regularly using fluoridated toothpaste.

• Study Type: Interventional
• Enrollment (Actual): 114
• Phase: Phase 3

Contacts and Locations

Study Locations

• Brazil
  • SP
    • Santos, SP, Brazil, 11045551
      • Eloisa Andrade de Paula

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Patients were at least 18 years old.
• Patients had good general and oral health, and did not report any type of tooth sensitivity (TS).
• The participants were required to have six caries-free maxillary anterior teeth and without restorations, absence of periodontal disease and must reviewed and signed the informed consent form.
• The central incisors should be shade A2 or darker as judged by comparison with a value-oriented shade guide (Vita Classical, Vita Zahnfabrik, Bad Säckingen, Germany).

Exclusion Criteria:

• Participants with anterior restorations or dental prosthesis, with orthodontics apparatus, with severe internal tooth discoloration (tetracycline stains, fluorosis, pulpless teeth) were not included in the study.
• Pregnant/lactating women, participants with any other pathology that could cause sensitivity (such as recession, dentine exposure, presence of visible cracks in teeth), taking anti-inflammatory and/or analgesic drugs, smokers, bruxists or participants that had undergone tooth-whitening procedures were also excluded.
• Patients that reported some earlier or present health problems in stomach, heart, kidney and liver, participants reporting continuous use of anti-inflammatory and/or analgesic drugs were excluded.
• Diabetics, hypertensive or patients with known allergy to acetaminophen and lactose.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Triple

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: acetam/ketoro tromet group; One hour before in-office bleaching patients received either the acetaminophen 750 mg (Paracetamol 750 mg, Bioativa compounding pharmacy) and ketorolac tromethamine oral 10 mg (Toragesic® 10 mg, EMS Sigma Farma). The operator administered the first dose of drug 1 h before the protocol, and extra doses were administered every 8 h for 48 h to keep a safe maximum daily dosage of 4000 mg of acetaminophen and 40 mg of ketorolac tromethamine.	Drug: acetam/ketoro tromet group; One hour before in-office bleaching patients received either the acetaminophen 750 mg (Paracetamol 750 mg, Bioativa compounding pharmacy) and ketorolac tromethamine oral 10 mg (Toragesic® 10 mg, EMS Sigma Farma). The operator administered the first dose of drug 1 h before the protocol, and extra doses were administered every 8 h for 48 h to keep a safe maximum daily dosage of 4000 mg of acetaminophen and 40 mg of ketorolac tromethamine.
Placebo Comparator: Placebo group; One hour before in-office bleaching patients received either placebo.	Drug: Placebo group; One hour before in-office bleaching patients received either placebo,The operator administered the first dose of drug 1 h before the protocol, and extra doses were administered every 8 h for 48 h.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Absolute risk of tooth sensitivity (TS)	The TS was evaluated during bleaching to 48 h post-bleaching. The patient was asked to binary outcome if the sensitivity is present ou not present.	48 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Intensity of TS	The intensity of TS was evaluated during bleaching up to 1 h, from 12 h up to 18h, from 18h up to 24 h, from 24h up to 48 h post-bleaching in both sessions. The patient was asked to indicate the numerical value of the degree of sensitivity for each one of the periods above, using a five-point Numeric Rating Scale (NRS) where 0 = none, 1 = mild, 2 = moderate, 3 = considerable and 4 = severe.	48 hours
Color	Color obtained with the Vita Classical and Vita Bleached guides between baseline vs. 1 month post bleaching.	30 days

Collaborators and Investigators

• Sponsor: Universidade Estadual de Ponta Grossa
• Collaborators: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; Universidade Estadual do Oeste do Paraná

Study record dates

Study Major Dates

• Study Start (Actual): November 5, 2017
• Primary Completion (Actual): December 1, 2017
• Study Completion (Actual): December 1, 2018

Study Registration Dates

• First Submitted: October 13, 2017
• First Submitted That Met QC Criteria: November 10, 2017
• First Posted (Actual): November 17, 2017

Study Record Updates

• Last Update Posted (Actual): November 13, 2019
• Last Update Submitted That Met QC Criteria: November 11, 2019
• Last Verified: November 1, 2019

More Information

Terms related to this study

• Keywords: Analgesics; Tooth Bleaching; Hydrogen Peroxide
• Additional Relevant MeSH Terms: Stomatognathic Diseases; Tooth Diseases; Dentin Sensitivity
• Other Study ID Numbers: 45733615.6.0000.0109

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No