A New Prognostic Scoring System for Spontaneous Ruptured Hepatocellular

A New Prognostic Scoring System for Spontaneous Ruptured Hepatocellular Carcinoma: A Retrospective Study

Develop a new scoring system for HCC patients with tumor rupture.

Study Overview

• Status: Completed
• Conditions: Rupture, Spontaneous
• Intervention / Treatment: Procedure: Liver resection

Detailed Description

There has been no special prognostic scoring system for HCC patients with tumor rupture in the literature. In this work, we obtained all survival risk factors of ruptured HCC patients who underwent partial hepatectomy using multivariable Cox regression analysis. Furthermore, we develop and validate a new postoperative scoring system for patients with spontaneous HCC rupture based on the these results.

• Study Type: Observational
• Enrollment (Actual): 129

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 15 years to 75 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Ten year HCC rupture patients who received partial hepatectomy at Tongji Hospital of the Huazhong University of Science and Technology

Description

Inclusion Criteria:

• Received partial hepatectomy; with Child A or B liver function.

Exclusion Criteria:

• Without complete data；loss of follow-up; had reveived repeated transcatheter arterial chemoembolization before rupture; received non-radical resection.

Study Plan

How is the study designed?

Design Details

• Observational Models: Cohort
• Time Perspectives: Retrospective

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Analysis before liver resection; Multivariate analysis of predictive factors associated with survival	Procedure: Liver resection; Partial hepatectomy comprised single or multiple hepatic resections aiming at excising all visible malignant tissue.
Different risk group; Low-risk group, moderate-risk group, high-risk group	Procedure: Liver resection; Partial hepatectomy comprised single or multiple hepatic resections aiming at excising all visible malignant tissue.
Model comparison; Comparison of models in predicting survival	Procedure: Liver resection; Partial hepatectomy comprised single or multiple hepatic resections aiming at excising all visible malignant tissue.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Overall survival	Overall survival after partial hepatectomy	3 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Disease-free survival	Recurrence-free survival after partial hepatectomy	3 years

Collaborators and Investigators

• Sponsor: Huazhong University of Science and Technology
• Investigators: Study Chair: Bi-xiang Zhang, Prof, PHD, Huazhong University of Science and Technology

Study record dates

Study Major Dates

• Study Start (Actual): January 1, 2005
• Primary Completion (Actual): May 1, 2015
• Study Completion (Actual): December 31, 2017

Study Registration Dates

• First Submitted: April 4, 2018
• First Submitted That Met QC Criteria: April 12, 2018
• First Posted (Actual): April 20, 2018

Study Record Updates

• Last Update Posted (Actual): April 20, 2018
• Last Update Submitted That Met QC Criteria: April 12, 2018
• Last Verified: April 1, 2018

More Information

Terms related to this study

• Keywords: surgery; survival; hepatocellular carcinoma; scoring system; homogeneity and discriminatory ability
• Additional Relevant MeSH Terms: Wounds and Injuries; Pathological Conditions, Anatomical; Rupture; Rupture, Spontaneous
• Other Study ID Numbers: Zhupeng002

Drug and device information, study documents

• Studies a U.S. FDA-regulated device product: No